Filtered By:
Source: American Heart Journal
This page shows you your search results in order of relevance. This is page number 18.
Order by Relevance | Date
Total 491 results found since Jan 2013.
Vorapaxar in patients with peripheral artery disease and acute coronary syndrome: Insights from Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER)
Background: In the TRACER trial, vorapaxar, a protease-activated receptor-1 antagonist, plus standard care in non–ST-segment elevation acute coronary syndrome (NSTE ACS) patients did not significantly reduce the primary composite end point but reduced a key secondary end point and significantly increased bleeding. History of peripheral artery disease (PAD) was a risk-enrichment inclusion criterion. We investigated the efficacy and safety of vorapaxar in NSTE ACS patients with documented PAD.Methods: TRACER was a double-blind, randomized trial comparing vorapaxar with placebo in 12,944 patients with NSTE ACS.Results: In t...
Source: American Heart Journal - July 7, 2014 Category: Cardiology Authors: William Schuyler Jones, Pierluigi Tricoci, Zhen Huang, David J. Moliterno, Robert A. Harrington, Peter R. Sinnaeve, John Strony, Frans Van de Werf, Harvey D. White, Claes Held, Paul W. Armstrong, Philip E. Aylward, Edmond Chen, Manesh R. Patel, Kenneth W. Tags: Peripheral Vascular Disease Source Type: research
Finding atrial fibrillation in stroke patients: Randomised evaluation of enhanced and prolonged Holter-monitoring - Find-AF -Rationale and Design
Source: American Heart Journal - July 3, 2014 Category: Cardiology Authors: Mark Weber-Krüger, Götz Gelbrich, Raoul Stahrenberg, Jan Liman, Pawel Kermer, Gerhard F. Hamann, Joachim Seegers, Klaus Gröschel, Rolf Wachter, Find-AFRANDOMISED investigators Source Type: research
National Trends in Stroke after Acute Myocardial Infarction among Medicare Patients in the United States: 1999-2010
Source: American Heart Journal - June 14, 2014 Category: Cardiology Authors: Yun Wang, Judith H. Lichtman, Kumar Dharmarajan, Frederick A. Masoudi, Joseph S. Ross, John A. Dodson, Jersey Chen, John A. Spertus, Sarwat I. Chaudhry, Brahmajee K. Nallamothu, Harlan M. Krumholz Source Type: research
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: Rationale and design of the ODYSSEY Outcomes trial
Publication date: Available online 7 August 2014 Source:American Heart Journal Author(s): Gregory G. Schwartz , Laurence Bessac , Lisa G. Berdan , Deepak L. Bhatt , Vera Bittner , Rafael Diaz , Shaun G. Goodman , Corinne Hanotin , Robert A. Harrington , J. Wouter Jukema , Kenneth W. Mahaffey , Angèle Moryusef , Robert Pordy , Matthew T. Roe , Tyrus Rorick , William J. Sasiela , Cheerag Shirodaria , Michael Szarek , Jean-François Tamby , Pierluigi Tricoci , Harvey White , Andreas Zeiher , Philippe Gabriel Steg Following acute coronary syndrome (ACS), the risk for future cardiovascular events is high and is related to le...
Source: American Heart Journal - October 20, 2014 Category: Cardiology Source Type: research
Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population
Conclusions This trial is evaluating LDL-C lowering beyond previously targeted LDL-C levels. The results depend on achieving the desired separation of LDL-C with ezetimibe and on the assumption that ezetimibe’s lowering of LDL-C will have similar event reduction efficacy as the LDL-C lowering from a statin. The results could affect future therapies and guidelines.
Source: American Heart Journal - October 20, 2014 Category: Cardiology Source Type: research
EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy
Conclusions In stable post-MI patients on evidence-based medical therapy, the combination of oral high-dose vitamins and chelation therapy compared with double placebo reduced clinically important cardiovascular events to an extent that was both statistically significant and of potential clinical relevance.
Source: American Heart Journal - October 20, 2014 Category: Cardiology Source Type: research
A multifaceted intervention to narrow the evidence-based gap in the treatment of acute coronary syndromes: Rationale and design of the Brazilian Intervention to Increase Evidence Usage in Acute Coronary Syndromes (BRIDGE-ACS) cluster-randomized trial
Publication date: March 2012 Source:American Heart Journal, Volume 163, Issue 3 Author(s): Otávio Berwanger , Hélio P. Guimarães , Ligia N. Laranjeira , Alexandre B. Cavalcanti , Alessandra Kodama , Ana Denise Zazula , Eliana Santucci , Elivane Victor , Uri A. Flato , Marcos Tenuta , Vitor Carvalho , Vera Lucia Mira , Karen S. Pieper , Luiz Henrique Mota , Eric D. Peterson , Renato D. Lopes Translating evidence into clinical practice in the management of acute coronary syndromes (ACS) is challenging. Few ACS quality improvement interventions have been rigorously evaluated to determine their impact on patient care and ...
Source: American Heart Journal - October 20, 2014 Category: Cardiology Source Type: research
Platelet function monitoring in elderly patients on prasugrel after stenting for an acute coronary syndrome: Design of the randomized antarctic study
Conclusion ANTARCTIC is a nationwide, prospective, open-label study testing a strategy of platelet function monitoring with dose and drug adjustment to reduce ischemic and bleeding complications in elderly ACS patients undergoing coronary stenting.
Source: American Heart Journal - October 31, 2014 Category: Cardiology Source Type: research
Anti-streptokinase antibodies and outcome of fibrinolytic therapy with streptokinase for left-sided prosthetic valve thrombosis
Conclusion Anti-SK antibody titres are not associated with success of fibrinolytic therapy using SK in patients with left-sided PVT.
Source: American Heart Journal - October 31, 2014 Category: Cardiology Source Type: research
Balancing the risks of bleeding and stent thrombosis: A decision analytic model to compare duration of dual antiplatelet therapy after drug-eluting stents
Conclusions Small absolute differences in the risk of ischemic events with longer DAPT would be sufficient to outweigh the known bleeding risks.
Source: American Heart Journal - November 17, 2014 Category: Cardiology Source Type: research
Antistreptokinase antibodies and outcome of fibrinolytic therapy with streptokinase for left-sided prosthetic valve thrombosis
Conclusion Anti-SK antibody titers are not associated with success of fibrinolytic therapy using SK in patients with left-sided PVT.
Source: American Heart Journal - November 17, 2014 Category: Cardiology Source Type: research
Design and rationale for the Minimizing Adverse haemorrhagic events by TRansradial access site and systemic Implementation of angioX program
Publication date: December 2014 Source:American Heart Journal, Volume 168, Issue 6 Author(s): Marco Valgimigli Background Transradial intervention (TRI) and bivalirudin infusion compared with transfemoral coronary intervention or unfractionated heparin plus glycoprotein IIb/IIIa inhibitors decrease bleeding complications in patients with acute coronary syndromes (ACS). Although bleeding is thought to be associated with worse outcomes, it remains unclear whether TRI and bivalirudin both independently lower ischemic or combined ischemic and bleeding complications in ACS patients undergoing contemporary invasive management....
Source: American Heart Journal - November 25, 2014 Category: Cardiology Source Type: research
Balancing the risks of bleeding and stent thrombosis: A decision analytic model to compare durations of dual antiplatelet therapy after drug-eluting stents
Conclusions Small absolute differences in the risk of ischemic events with longer DAPT would be sufficient to outweigh the known bleeding risks.
Source: American Heart Journal - December 2, 2014 Category: Cardiology Source Type: research
Transition from apixaban to warfarin—addressing excess stroke, systemic embolism, and major bleeding
Publication date: January 2015 Source:American Heart Journal, Volume 169, Issue 1 Author(s): John A. Cairns , Jeffrey I. Weitz
Source: American Heart Journal - December 9, 2014 Category: Cardiology Source Type: research
Off-hour admission and outcomes for patients with acute myocardial infarction undergoing percutaneous coronary interventions
Conclusions Patients who were admitted during off-hours did not have higher mortality or readmission rates as compared with ones admitted during regular hours at an academic medical center.
Source: American Heart Journal - December 9, 2014 Category: Cardiology Source Type: research
