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Source: Journal of the American College of Cardiology

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Total 269 results found since Jan 2013.

Serial Magnetic Resonance Imaging in Hypoplastic Left Heart Syndrome Gives Valuable Insight Into Ventricular and Vascular Adaptation
Conclusions: In HLHS, serial MRI shows the adaptation of the systemic RV after HF with volume reduction in the context of a preserved stroke volume and an increased ejection fraction. The staged palliation in HLHS may be a risk factor particularly for reduced left pulmonary artery growth in itself as no factors investigated in this study were found to significantly impact on this.
Source: Journal of the American College of Cardiology - January 30, 2013 Category: Cardiology Authors: Hannah R. Bellsham-Revell, Shane M. Tibby, Aaron J. Bell, Thomas Witter, John Simpson, Philipp Beerbaum, David Anderson, Conal B. Austin, Gerald F. Greil, Reza Razavi Tags: Congenital Heart Disease Source Type: research

Transcatheter Aortic Valve Implantation With the Edwards SAPIEN Versus the Medtronic CoreValve Revalving System Devices: A Multicenter Collaborative Study: The PRAGMATIC Plus Initiative (Pooled-RotterdAm-Milano-Toulouse In Collaboration)
Objectives: The aim of this study was to compare outcomes after transfemoral transcatheter aortic valve implantation with the Medtronic CoreValve (MCV) versus the Edwards SAPIEN/SAPIEN XT transcatheter heart valve (ESV) for severe aortic stenosis. Background: No large matched comparison study has been conducted so far evaluating both commercially available devices. Methods: The data from databases of 4 experienced European centers were pooled and analyzed. Due to differences in baseline clinical characteristics, propensity score matching was performed. Study objectives were Valve Academic Research Consortium outcomes ...
Source: Journal of the American College of Cardiology - January 21, 2013 Category: Cardiology Authors: Alaide Chieffo, Gill Louise Buchanan, Nicolas M. Van Mieghem, Didier Tchetche, Nicolas Dumonteil, Azeem Latib, Robert M.A. van der Boon, Olivier Vahdat, Bertrand Marcheix, Bruno Farah, Patrick W. Serruys, Jean Fajadet, Didier Carrié, Peter P.T. de Jaeger Tags: Heart Valve Disease Source Type: research

Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm
Objectives: We sought to assess the effect of atrial fibrillation (AF) on atrial thrombogenesis in humans by determining the impact of rate and rhythm. Background: Although AF is known to increase the risk of thromboembolic stroke from the left atrium (LA), the exact mechanisms remain poorly understood. Methods: We studied 55 patients with AF who underwent catheter ablation while in sinus rhythm; 20 patients were induced into AF, 20 patients were atrial paced at 150 beats/min, and 15 were control patients. Blood samples were taken from the LA, right atrium, and femoral vein at baseline and at 15 min in all 3 groups. P...
Source: Journal of the American College of Cardiology - January 21, 2013 Category: Cardiology Authors: Han S. Lim, Scott R. Willoughby, Carlee Schultz, Cheryl Gan, Muayad Alasady, Dennis H. Lau, Darryl P. Leong, Anthony G. Brooks, Glenn D. Young, Peter M. Kistler, Jonathan M. Kalman, Matthew I. Worthley, Prashanthan Sanders Tags: Heart Rhythm Disorders Source Type: research

Atrial Fibrillation and Thrombosis: The Missing Molecular Links⁎
Nonvalvular atrial fibrillation (AF) confers a 5-fold increased risk of stroke and systemic thromboembolism (TE), especially in the presence of stroke risk factors (). AF is common, and the TE manifestations are evident in many diverse cardiovascular conditions. For example, transient new-onset AF in acute myocardial infarction is a risk factor for stroke (). Also, patients with left ventricular systolic impairment with associated AF are at high risk of TE (). Fortunately, the use of anticoagulation therapy reduces the risk of stroke and/or TE (by 64%) as well as all-cause mortality (by 26%), whereas aspirin results in a n...
Source: Journal of the American College of Cardiology - January 21, 2013 Category: Cardiology Authors: Andrew D. Blann, Gregory Y.H. Lip Tags: Heart Rhythm Disorders: Editorial Comment Source Type: research

The Year in Review of Clinical Cardiac Electrophysiology
This past year saw multiple important advances in the field clinical cardiac electrophysiology. Seminal articles describing new anticoagulant drugs for stroke prevention in atrial fibrillation were published. New results that raise questions regarding the safety of dronedarone and several new promising techniques in AF ablation were described. Important articles that refine our understanding of the risk of sudden death among Wolff-Parkinson-White patients were published. In the basic and translational sciences, the application of gene therapy to the study and potential treatment of arrhythmias was described, whereas geneti...
Source: Journal of the American College of Cardiology - January 14, 2013 Category: Cardiology Authors: Gregory M. Marcus, Edmund Keung, Melvin M. Scheinman Tags: YEAR IN CARDIOLOGY SERIES Source Type: research

Behavioral Mechanisms, Elevated Depressive Symptoms, and the Risk for Myocardial Infarction or Death in Individuals With Coronary Heart Disease: The REGARDS (Reason for Geographic and Racial Differences in Stroke) Study
Conclusions: Our findings suggest potential roles for behavioral interventions targeting smoking and physical inactivity in patients with CHD and comorbid depression.
Source: Journal of the American College of Cardiology - January 7, 2013 Category: Cardiology Authors: Siqin Ye, Paul Muntner, Daichi Shimbo, Suzanne E. Judd, Joshua Richman, Karina W. Davidson, Monika M. Safford Tags: Coronary Artery Disease Source Type: research

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease
The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular events in patients with clinically stable coronary disease. Background: The presence of activated neutrophils in culprit atherosclerotic plaques of patients with unstable coronary disease raises the possibility that inhibition of neutrophil function with colchicine may reduce the risk of plaque instability and thereby improve clinical outcomes in patients with stable coronary disease. Methods: In a clinical trial with a prospective, randomized, observer-blinded endpoint design, 532 patients with stable coron...
Source: Journal of the American College of Cardiology - December 26, 2012 Category: Cardiology Authors: Stefan M. Nidorf, John W. Eikelboom, Charley A. Budgeon, Peter L. Thompson Tags: Clinical Trial Source Type: research

Remnant Cholesterol: “Non-(HDL-C + LDL-C)” as a Coronary Artery Disease Risk Factor⁎
In this issue the Journal, Varbo et al. () demonstrate that irrespective of the fasting state, the cholesterol transported by remnant lipoproteins is a robust predictor of coronary artery disease (CAD) risk. Their findings provide clarification to the debate regarding triglyceride-rich lipoproteins and atherosclerosis (). Overall, a consensus is emerging on the basis of clinical and population data and genetic studies that fasting and nonfasting plasma triglycerides are predictive of both CAD and stroke risk, although the relationship is attenuated after correction for associated variables, including high-density lipoprote...
Source: Journal of the American College of Cardiology - December 26, 2012 Category: Cardiology Authors: Ruth McPherson Tags: Cardiometabolic Risk: Editorial Comment Source Type: research

The Current State of Niacin in Cardiovascular Disease Prevention: A Systematic Review and Meta-Regression
Conclusions: The consensus perspective derived from available clinical data supports that niacin reduces CVD events and, further, that this may occur through a mechanism not reflected by changes in high-density lipoprotein cholesterol concentration.
Source: Journal of the American College of Cardiology - December 26, 2012 Category: Cardiology Authors: Paul M. Lavigne, Richard H. Karas Tags: Cardiometabolic Risk Source Type: research

Association Between Cardiovascular Autonomic Neuropathy and Left Ventricular Dysfunction: DCCT/EDIC Study (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications)
Objectives: The goal of these studies was to determine the association between cardiovascular autonomic neuropathy (CAN) and indices of left ventricle (LV) structure and function in patients with type 1 diabetes (T1DM) in the DCCT/EDIC (Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications) study. Background: The pathophysiology of LV dysfunction in T1DM remains unclear, especially when the LV ejection fraction (EF) is preserved. Whether CAN is associated with LV dysfunction is unclear. Methods: Indices of LV structure and function were obtained by cardiac magnetic resonanc...
Source: Journal of the American College of Cardiology - December 26, 2012 Category: Cardiology Authors: Rodica Pop-Busui, Patricia A. Cleary, Barbara H. Braffett, Catherine L. Martin, William H. Herman, Phillip A. Low, Joao A.C. Lima, David A. Bluemke, DCCT/EDIC Research Group Tags: Heart Failure Source Type: research

Treatment Targets in Atrial Fibrillation: “Is Feeling Better Good Enough?”⁎
Atrial fibrillation (AF) is the most common sustained arrhythmia necessitating medical therapy. The majority of AF patients have associated cardiovascular comorbidities that increase the risk of negative cardiovascular outcomes, including excess morbidity, hospitalizations, and mortality (). Data assessing a disease management strategy of rate versus rhythm control have produced clear variations when viewed from a real-world clinical perspective (). These data emphasize that the treatment of AF involves 3 nonmutually exclusive principles: 1) prevention of stroke and systemic embolism; 2) ventricular rate control during AF;...
Source: Journal of the American College of Cardiology - December 26, 2012 Category: Cardiology Authors: Michael H. Kim Tags: Heart Rhythm Disorders in Heart Failure: Editorial Comment Source Type: research

Omega-3 Fatty Acids for the Prevention of Recurrent Symptomatic Atrial Fibrillation: Results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) Trial
Conclusions: Pharmacological supplementation with 1 g of n-3 PUFA for 1 year did not reduce recurrent AF. (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation [FORWARD]; NCT00597220)
Source: Journal of the American College of Cardiology - December 26, 2012 Category: Cardiology Authors: Alejandro Macchia, Hugo Grancelli, Sergio Varini, Daniel Nul, Nicolás Laffaye, Javier Mariani, Daniel Ferrante, Raúl Badra, Julio Figal, Silvina Ramos, Gianni Tognoni, Hernán C. Doval, GESICA Investigators Tags: Heart Rhythm Disorders in Heart Failure Source Type: research

Prognosis Among Healthy Individuals Discharged With a Primary Diagnosis of Syncope
This study sought to examine the risk of major cardiac adverse events and death in a nationwide cohort of patients without previous comorbidity admitted for syncope. Background: Syncope is a common clinical event, but knowledge of prognosis is not fully elucidated in healthy individuals. Methods: Patients without previous comorbidity admitted for syncope in Denmark from 2001 to 2009 were identified in nationwide administrative registries and matched by sex and age with 5 control subjects from the Danish population. The risk of death or recurrent syncope, implantation of pacemaker or implantable cardioverter-defibrillat...
Source: Journal of the American College of Cardiology - December 17, 2012 Category: Cardiology Authors: Martin Huth Ruwald, Morten Lock Hansen, Morten Lamberts, Carolina Malta Hansen, Michael Vinther, Lars Køber, Christian Torp-Pedersen, Jim Hansen, Gunnar Hilmar Gislason Tags: Heart Rhythm Disorders Source Type: research

Percutaneous Left Atrial Appendage Suture Ligation Using the LARIAT Device in Patients With Atrial Fibrillation: Initial Clinical Experience
Conclusions: LAA closure with the LARIAT device can be performed effectively with acceptably low access complications and periprocedural adverse events in this observational study.
Source: Journal of the American College of Cardiology - October 16, 2012 Category: Cardiology Authors: Krzysztof Bartus, Frederick T. Han, Jacek Bednarek, Jacek Myc, Boguslaw Kapelak, Jerzy Sadowski, Jacek Lelakowski, Stanislaw Bartus, Steven J. Yakubov, Randall J. Lee Tags: Mini-Focus: Left Atrial Closure in Atrial Fibrillation Source Type: research