Filtered By:
Source: Journal of the American College of Cardiology
This page shows you your search results in order of date. This is page number 10.
Order by Relevance | Date
Total 269 results found since Jan 2013.
Reply One More “C” for CHA 2 DS 2 -VASc Score
We thank Dr. Siu for his comments regarding our recently published paper (1) about the usefulness of the CHA2DS2-VASc score for refining stroke risk stratification among patients with atrial fibrillation (AF) having an ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) score of 0 to 5. We agree that the risk of ischemic stroke for Chinese AF patients with a CHA2DS2-VASc score of 0 is higher than that of Caucasians. However, it does not mean that non-vitamin K antagonist oral anticoagulants (NOACs) should be routinely prescribed for these patients. Our previous study demonstrated that the risk of ischemic strok...
Source: Journal of the American College of Cardiology - April 13, 2015 Category: Cardiology Source Type: research
One More “C” for CHA 2 DS 2 -VASc Score?
Oral anticoagulation therapy for stroke prevention is the cornerstone of atrial fibrillation (AF) management. Current international guidelines focus on accurate identification of “truly low-risk” patients in order to exclude them from such therapy, reserving it for those with immediate or high stroke risk. Accordingly, the CHA2DS2-VASc score has been recommended as the standard means of stroke risk stratification. With the exception of those with a CHA2DS2-VASc score of 0, that is an annual stroke risk of 0.7%/year, oral anticoagulation therapy should be considered/recommended (Class I, Level of Evidence: A, and Class...
Source: Journal of the American College of Cardiology - April 13, 2015 Category: Cardiology Source Type: research
Readmissions After Carotid Artery Revascularization in the Medicare Population
ConclusionsAlmost 10% of Medicare patients undergoing carotid revascularization were readmitted within 30 days of discharge. Compared with CEA, CAS was associated with a greater readmission risk. However, hospitals' RSRR did not differ by their proportional CAS use.
Source: Journal of the American College of Cardiology - April 6, 2015 Category: Cardiology Source Type: research
Oral Anticoagulation, Aspirin, or No Therapy in Patients With Nonvalvular AF With 0 or 1 Stroke Risk Factor Based on the CHA 2 DS 2 -VASc Score
ConclusionsLow-risk patients (CHA2DS2-VASc = 0 [male], 1 [female]) have a truly low risk for stroke and bleeding. With 1 additional stroke risk factor (CHA2DS2-VASc = 1 [male], = 2 [female]), there was a significant increase in event rates (particularly mortality) if nonanticoagulated.
Source: Journal of the American College of Cardiology - April 6, 2015 Category: Cardiology Source Type: research
Patients With Atrial Fibrillation and a CHA 2 DS 2 -VASc Score of 1 Are They at Low or High Stroke Risk? ∗
Nonvalvular atrial fibrillation carries a risk for developing ischemic stroke that is lowered by anticoagulant therapy (1). This risk is not uniform and depends on whether a patient has either none or ≥1 of the following factors, known as the CHA2DS2-VASc stroke risk score: congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65 to 74 years, sex category. Both European (2) and U.S. (3) guidelines advocate estimation of a patient’s stroke risk by use of the CHA2DS2-VASc score for initial risk stratification. The European Society of Cardiol...
Source: Journal of the American College of Cardiology - April 6, 2015 Category: Cardiology Source Type: research
Relationship of Oxidized Phospholipids on Apolipoprotein B-100 to Cardiovascular Outcomes in Patients Treated With Intensive Versus Moderate Atorvastatin Therapy The TNT Trial
ConclusionsElevated OxPL-apoB levels predict secondary MACE in patients with stable CHD, a risk that is mitigated by atorvastatin 80 mg. (A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels [TNT]; NCT00327691)
Source: Journal of the American College of Cardiology - March 30, 2015 Category: Cardiology Source Type: research
First-in-Human Transcatheter Tricuspid Valve Repair in a Patient With Severely Regurgitant Tricuspid Valve
ConclusionsTranscatheter tricuspid valve repair could become an effective treatment for high–surgical risk patients who are non-responsive to optimal medical therapy.
Source: Journal of the American College of Cardiology - March 23, 2015 Category: Cardiology Source Type: research
Is the Long-Term Outcome of PCI or CABG in Insulin-Treated Diabetic Patients Really Worse Than Non-Insulin-Treated Ones?
In a recent issue of the Journal, Dangas et al. (1), after analyzing 1,850 subjects from the FREEDOM (Comparison of Two Treatments for Multivessel Coronary Artery Disease in Individuals With Diabetes) trial, found that in patients with diabetes and multivessel coronary artery disease, the rate of major adverse cardiovascular events (death, myocardial infarction, or stroke) is higher in patients treated with insulin than it is in those not treated with insulin. Their work is excellent, and the results deserved to be considered given the large number of patients with diabetes and multivessel coronary artery disease who are...
Source: Journal of the American College of Cardiology - March 16, 2015 Category: Cardiology Source Type: research
How Recent Data Have Impacted the Treatment of Internal Carotid Artery Stenosis
Carotid atherosclerosis accounts for approximately 10% of ischemic stroke cases. Multifaceted medical therapy reduces the risk of stroke in patients with carotid stenosis. Revascularization with endarterectomy or stenting can benefit select patients. In recent years, new information has been obtained regarding optimal selection of revascularization candidates. In addition, new concepts have been formulated regarding the relationship between carotid stenosis and vascular cognitive impairment. Finally, the declining rate of stroke with improved medical therapy has led to the launch of new clinical trials to determine the con...
Source: Journal of the American College of Cardiology - March 16, 2015 Category: Cardiology Source Type: research
Smoking Is Associated With Adverse Clinical Outcomes in Patients Undergoing Revascularization With PCI or CABG The SYNTAX Trial at 5-Year Follow-Up
ConclusionsSmoking is associated with poor clinical outcomes after revascularization in patients with complex CAD. This places further emphasis on efforts at smoking cessation to improve revascularization benefits. (SYNTAX Study: TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries; NCT00114972)
Source: Journal of the American College of Cardiology - March 16, 2015 Category: Cardiology Source Type: research
Prevalence, Impact, and Predictive Value of Detecting Subclinical Coronary and Carotid Atherosclerosis in Asymptomatic Adults The BioImage Study
ConclusionsDetection of subclinical carotid or coronary atherosclerosis improves risk predictions and reclassification compared with conventional risk factors, with comparable results for either modality. Cost-effective analyses are warranted to define the optimal roles of these complementary techniques. (BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population; NCT00738725)
Source: Journal of the American College of Cardiology - March 16, 2015 Category: Cardiology Source Type: research
Randomized Trial of Complete Versus Lesion-Only Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI and Multivessel Disease The CvLPRIT Trial
ConclusionsIn patients presenting for P-PCI with multivessel disease, index admission complete revascularization significantly lowered the rate of the composite primary endpoint at 12 months compared with treating only the IRA. In such patients, inpatient total revascularization may be considered, but larger clinical trials are required to confirm this result and specifically address whether this strategy is associated with improved survival. (Complete Versus Lesion-only Primary PCI Pilot Study [CvLPRIT]; ISRCTN70913605)
Source: Journal of the American College of Cardiology - March 9, 2015 Category: Cardiology Source Type: research
Pre-Frailty and Risk of Cardiovascular Disease in Elderly Men and Women The Pro.V.A. Study
ConclusionsOur findings suggest that pre-frailty, which is potentially reversible, is independently associated with a higher risk of older adults developing CVD. Among the physical domains of pre-frailty, low gait speed seems to be the best predictor of future CVD.
Source: Journal of the American College of Cardiology - March 9, 2015 Category: Cardiology Source Type: research
6- Versus 24-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents in Patients Nonresistant to Aspirin The Randomized, Multicenter ITALIC Trial
ConclusionsRates of bleeding and thrombotic events were not significantly different according to 6- versus 24-month DAPT after PCI with new-generation DES in good aspirin responders. (Is There A LIfe for DES After Discontinuation of Clopidogrel [ITALICplus]; NCT01476020)
Source: Journal of the American College of Cardiology - February 23, 2015 Category: Cardiology Source Type: research
Should Atrial Fibrillation Patients With 1 Additional Risk Factor of the CHA 2 DS 2 -VASc Score (Beyond Sex) Receive Oral Anticoagulation?
ConclusionsNot all risk factors in CHA2DS2-VASc score carry an equal risk, with age 65 to 74 years associated with the highest stroke rate. Oral anticoagulation should be considered for AF patients with 1 additional stroke risk factor given their high risk of ischemic stroke.
Source: Journal of the American College of Cardiology - February 16, 2015 Category: Cardiology Source Type: research
