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Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Mechanical thrombectomy for the treatment of acute ischaemic stroke following pulmonary lobectomy.
We report the case of a patient developing an acute ischaemic stroke following pulmonary lobectomy, who was transferred to the regional neurosciences unit, despite the absence of an established referral pathway, to undergo mechanical thrombectomy, with significant prognostic neurological benefit. We would advocate all cardiothoracic centres identify their regional neurosciences unit and initiate discussion to establish a referral pathway. PMID: 30855160 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - March 10, 2019 Category: Surgery Authors: Ali JM, Wolff I, Falconieri F, Aresu G, Coonar AS, Joshi Y, Peryt A Tags: Ann R Coll Surg Engl Source Type: research

Haematomas after carotid endarterectomy can be reduced by direct pressure to the neck postoperatively.
Conclusion During recovery from CEA, focused and prolonged pressure by the operating surgeon is a highly effective method of reducing haematoma. PMID: 29909667 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - June 18, 2018 Category: Surgery Authors: Saghir R, Humm G, Rix T Tags: Ann R Coll Surg Engl Source Type: research

Early outcomes of patients transferred with ruptured suprarenal aneurysm or dissection.
Conclusions Although the number of patients with rSRAD is low and those who are transferred alive are a self-selecting group, this study suggests that transfer of such patients to a specialist vascular centre is associated with acceptable mortality rates following emergency complex aortic repair. PMID: 29484940 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - February 27, 2018 Category: Surgery Authors: Rudarakanchana N, Hamady M, Harris S, Afify E, Gibbs R, Bicknell CD, Jenkins MP Tags: Ann R Coll Surg Engl Source Type: research

Variable life adjusted display methodology for continuous performance monitoring of carotid endarterectomy.
Conclusions Performance of carotid endarterectomy can be continuously assessed using VLAD methodology for units and individual surgeons. Early identification and correction of performance variation could facilitate improved quality of care. PMID: 29046083 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - October 19, 2017 Category: Surgery Authors: Kuhan G, McCollum DP, Renwick PM, Chetter IC, McCollum PT Tags: Ann R Coll Surg Engl Source Type: research

The effects of centralisation of vascular surgical services in the Bath, Bristol and Weston area on the carotid endarterectomy pathway.
Conclusion Centralisation has not significantly impacted the overall efficiency of the carotid endarterectomy pathway. This study highlights areas where improvement across the vascular network is required. This includes addressing the 35% patients that are not currently meeting the 14-day target and standardising the provision of care to outlying communities. Further follow-up is required to assess the longer term effects of centralisation. PMID: 28682128 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - July 6, 2017 Category: Surgery Authors: Partridge E, Brooks M, Curd C, Davis V, Oates C, McGeeney D Tags: Ann R Coll Surg Engl Source Type: research

Secondary prevention and cognitive function after stroke: a study protocol for a 5-year follow-up of the ASPIRE-S cohort
Introduction Cognitive impairment is common following stroke and can increase disability and levels of dependency of patients, potentially leading to greater burden on carers and the healthcare system. Effective cardiovascular risk factor control through secondary preventive medications may reduce the risk of cognitive decline. However, adherence to medications is often poor and can be adversely affected by cognitive deficits. Suboptimal medication adherence negatively impacts secondary prevention targets, increasing the risk of recurrent stroke and further cognitive decline. The aim of this study is to profile cognitive f...
Source: BMJ Open - March 27, 2017 Category: Journals (General) Authors: Rohde, D., Williams, D., Gaynor, E., Bennett, K., Dolan, E., Callaly, E., Large, M., Hickey, A. Tags: Open access, Cardiovascular medicine, Epidemiology Protocol Source Type: research

Efficacy and safety of rivaroxaban thromboprophylaxis after arthroplasty of the hip or knee: retrospective cohort study.
Conclusions Rivaroxaban is an effective and safe anticoagulant for thromboprophylaxis after hip arthroplasty or knee arthroplasty if used in a modified regimen involving enoxaparin administered in the inpatient setting followed by rivaroxaban upon hospital discharge. PMID: 27580310 [PubMed - in process]
Source: Annals of the Royal College of Surgeons of England - August 31, 2016 Category: Surgery Authors: Loganathan L, Hua A, Patel S, Gibbons C, Vizcaychipi MP Tags: Ann R Coll Surg Engl Source Type: research

Adverse outcomes after total and unicompartmental knee replacement in 101 330 matched patients: a study of data from the National Joint Registry for England and Wales
Publication date: 18–24 October 2014 Source:The Lancet, Volume 384, Issue 9952 Author(s): Alexander D Liddle , Andrew Judge , Hemant Pandit , David W Murray Background Total knee replacement (TKR) or unicompartmental knee replacement (UKR) are options for end-stage osteoarthritis. However, comparisons between the two procedures are confounded by differences in baseline characteristics of patients undergoing either procedure and by insufficient reporting of endpoints other than revision. We aimed to compare adverse outcomes for each procedure in matched patients. Methods With propensity score techniques, we compared ma...
Source: The Lancet - October 17, 2014 Category: Journals (General) Source Type: research

MELAS syndrome presenting as an acute surgical abdomen.
We describe the case of a young woman who presented as an acute surgical emergency, diagnosed as toxic megacolon necessitating an emergency total colectomy. MELAS syndrome was suspected postoperatively owing to persistent lactic acidosis and neurological symptoms. The diagnosis was later confirmed with histological and genetic studies. This case highlights the difficulties in diagnosing MELAS because of its unpredictable presentation and clinical course. We therefore recommend a high index of suspicion in cases of an acute surgical abdomen with additional neurological features or raised lactate. PMID: 24417855 [PubMed - in process]
Source: Annals of the Royal College of Surgeons of England - January 1, 2014 Category: Surgery Authors: Dindyal S, Mistry K, Angamuthu N, Smith G, Hilton D, Arumugam P, Mathew J Tags: Ann R Coll Surg Engl Source Type: research

Minimally invasive direct coronary artery bypass versus off-pump coronary surgery through sternotomy.
CONCLUSIONS: MIDCAB can be performed safely in appropriately selected patients with outcomes comparable with OPCAB. The potential benefits include shorter hospital stay, reduced need for blood transfusion and faster recovery. PMID: 24112493 [PubMed - as supplied by publisher]
Source: Annals of the Royal College of Surgeons of England - October 1, 2013 Category: Surgery Authors: Birla R, Patel P, Aresu G, Asimakopoulos G Tags: Ann R Coll Surg Engl Source Type: research

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