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Total 238 results found since Jan 2013.
Predicting The Onset Of Diabetes-Related Complications After A Diabetes Diagnosis With Machine Learning Algorithms
The burden of Diabetes has been ranked as the eighth cause in the ranking of causes of disability-adjusted life years (DALYs) all over the world [1,2], accounting for 2.8% of total DALYs and with an increase of more than 148% in 2019 as compared with the data obtained in 1990 [2]. Diabetes is one of the most significant factors increasing the risk of mortality, morbidity, and disability worldwide, and its economic burden demands new ways to curb diabetes healthcare expenditure [3]. Furthermore, people with diabetes are at greater risk of additionally suffering from cardiovascular diseases, such as heart attack or stroke [4...
Source: Diabetes Research and Clinical Practice - September 15, 2023 Category: Endocrinology Authors: Toni Mora, David Roche, Beatriz Rodr íguez-Sánchez Source Type: research
Association of Coronary Artery Calcium Detected by Routine Ungated CT Imaging With Cardiovascular Outcomes
CONCLUSIONS: Incidental CAC ≥100 was associated with an increased risk of all-cause death and adverse cardiovascular outcomes, beyond traditional risk factors. DL-CAC from routine non-ECG-gated CTs identifies patients at increased cardiovascular risk and holds promise as a tool for opportunistic screening to facilitate earlier intervention.PMID:37704309 | DOI:10.1016/j.jacc.2023.06.040
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Allison W Peng Ramzi Dudum Sneha S Jain David J Maron Bhavik N Patel Nishith Khandwala David Eng Akshay S Chaudhari Alexander T Sandhu Fatima Rodriguez Source Type: research
COVID-19 ’ s Impact on Heart Health Still Confounds Doctors
(ST. LOUIS) — Firefighter and paramedic Mike Camilleri once had no trouble hauling heavy gear up ladders. Now battling long COVID, he gingerly steps onto a treadmill to learn how his heart handles a simple walk.
“This is, like, not a tough-guy test so don’t fake it,” warned Beth Hughes, a physical therapist at Washington University in St. Louis.
[time-brightcove not-tgx=”true”]
Somehow, a mild case of COVID-19 set off a chain reaction that eventually left Camilleri with dangerous blood pressure spikes, a heartbeat that raced with slight exertion, and episodes of intense chest pain...
Source: TIME: Health - August 10, 2023 Category: Consumer Health News Authors: Lauran Needgaard/ Associated Press Tags: Uncategorized COVID-19 healthscienceclimate wire Source Type: news
Development and validation of a prediction model to predict major adverse cardiovascular events in elderly patients undergoing noncardiac surgery: A retrospective cohort study
CONCLUSIONS: This prediction model based on the traditional method could accurately predict the risk of MACEs after noncardiac surgery in elderly patients.PMID:37315395 | DOI:10.1016/j.atherosclerosis.2023.06.008
Source: Atherosclerosis - June 14, 2023 Category: Cardiology Authors: Kai Zhang Chang Liu Xiaoling Sha Siyi Yao Zhao Li Yao Yu Jingsheng Lou Qiang Fu Yanhong Liu Jiangbei Cao Jiaqiang Zhang Yitian Yang Weidong Mi Hao Li Source Type: research
Cardiovascular disease (CVD) outcomes and associated risk factors in a medicare population without prior CVD history: an analysis using statistical and machine learning algorithms
AbstractThere is limited information on predicting incident cardiovascular outcomes among high- to very high-risk populations such as the elderly ( ≥ 65 years) in the absence of prior cardiovascular disease and the presence of non-cardiovascular multi-morbidity. We hypothesized that statistical/machine learning modeling can improve risk prediction, thus helping inform care management strategies. We defined a population from the Medicare he alth plan, a US government-funded program mostly for the elderly and varied levels of non-cardiovascular multi-morbidity. Participants were screened for cardiovascular disease (CVD)...
Source: Internal and Emergency Medicine - June 9, 2023 Category: Emergency Medicine Source Type: research
Plain language summary of results from ORION-10 and ORION-11: Two studies to learn how well inclisiran works in people with high cholesterol
Future Cardiol. 2023 Jun 6. doi: 10.2217/fca-2022-0133. Online ahead of print.ABSTRACTWHAT IS THIS PLAIN LANGUAGE SUMMARY ABOUT?: This is a summary of the article describing the results of the ORION-10 and ORION-11 studies, which was published in the New England Journal of Medicine in April 2020. The studies included adult participants with atherosclerotic cardiovascular disease (ASCVD). ASCVD happens when the blood vessels that carry blood from the heart to other areas of the body are blocked by fatty build-up (plaque) causing a heart attack, stroke, or other problems. High levels of low-density lipoprotein cholesterol (L...
Source: Atherosclerosis - June 7, 2023 Category: Cardiology Authors: Kausik K Ray R Scott Wright Source Type: research
Milvexian Granted U.S. FDA Fast Track Designation for All Three Indications Under Evaluation in Phase 3 Librexia Program: Ischemic Stroke, Acute Coronary Syndrome and Atrial Fibrillation
RARITAN, NJ, May 25, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that all three prospective indications for milvexian, an investigational oral factor XIa (FXIa) inhibitor (being developed in collaboration with Bristol Myers Squibb), have now been granted Fast Track Designation by the U.S. Food and Drug Administration (FDA). The designations cover all three indication-seeking studies within the Phase 3 Librexia development program (Librexia STROKE, Librexia ACS and Librexia AF), which are all dosing patients. The Librexia program is unrivaled as the most comprehensive FXIa clinical...
Source: Johnson and Johnson - May 25, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news
Billions With Nutrition Deficiency!?
Almost no one gets enough selenium. Officially, at least a billion — with a B — people have a selenium deficiency.1
But I suspect the numbers are much higher than that.
You can’t get enough selenium from food alone anymore. That’s true even if you eat a healthy, varied diet. And you can thank Big Agra for that.
With their harsh pesticides, synthetic fertilizers, and single-crop strategy, these massive farms have stripped the nutrients out of the soil. No nutrients in the soil mean no nutrients in the food.
All of this makes it difficult — if not impossible — to get even some of the daily selenium you need to ...
Source: Al Sears, MD Natural Remedies - May 15, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Nutrition Source Type: news
Identification, characterization, and engineering of glycosylation in thrombolyticsa
Biotechnol Adv. 2023 May 12:108174. doi: 10.1016/j.biotechadv.2023.108174. Online ahead of print.ABSTRACTCardiovascular diseases, such as myocardial infarction, ischemic stroke, and pulmonary embolism, are the most common causes of disability and death worldwide. Blood clot hydrolysis by thrombolytic enzymes and thrombectomy are key clinical interventions. The most widely used thrombolytic enzyme is alteplase, which has been used in clinical practice since 1986. Another clinically used thrombolytic protein is tenecteplase, which has modified epitopes and engineered glycosylation sites, suggesting that carbohydrate modifica...
Source: Biotechnology Advances - May 14, 2023 Category: Biotechnology Authors: Martin Toul Veronika Slonkova Jan Mican Adam Urminsky Maria Tomkova Erik Sedlak David Bednar Jiri Damborsky Lenka Hernychova Zbynek Prokop Source Type: research
Percutaneous management of acute ischaemic stroke
Learning objectives To understand both the rationale and principles behind percutaneous management of stroke. To be aware of the evidence base for this treatment. To appreciate the current logistical challenges and how they might be overcome. Introduction In principle, the similarity between opening an occluded cerebral artery and an occluded coronary artery, when the perfusion to that organ is acutely compromised, is inescapable: to re-establish antegrade flow as quickly as possible to minimise downstream damage. There are, of course, important differences between an acute myocardial infarction (MI) and an acute ischaemic...
Source: Heart - April 25, 2023 Category: Cardiology Authors: Routledge, H., Curzen, N. Tags: Education in Heart Source Type: research
