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Childhood stroke : What are the special features of childhood stroke?
Abstract Childhood arterial ischemic stroke differs in essential aspects from adult stroke. It is rare, often relatively unknown among laypersons and physicians and the wide variety of age-specific differential diagnoses (stroke mimics) as well as less established care structures often lead to a considerable delay in the diagnosis of stroke. The possible treatment options in childhood are mostly off-label. Experiences in well-established acute treatment modalities in adult stroke, such as thrombolysis and mechanical thrombectomy are therefore limited in children and only based on case reports and case series. The...
Source: Hamostaseologie - October 23, 2017 Category: Hematology Authors: Gerstl L, Bonfert MV, Nicolai T, Dieterich M, Adamczyk C, Heinen F, Olivieri M, Steinlin M Tags: Nervenarzt Source Type: research

Stroke Prevention with Hydroxyurea Enabled through Research and Education (SPHERE): a Phase 2 primary stroke prevention trial in sub-Saharan Africa
Conclusion: SPHERE has built local capacity with high-quality research infrastructure and TCD screening for SCA in Tanzania. Fully enrolled, participants have a high prevalence of elevated baseline TCD velocities and splenomegaly. SPHERE will prospectively determine the benefits of hydroxyurea at MTD for primary stroke prevention, anticipating expanded access to hydroxyurea treatment across Tanzania.
Source: Acta Haematologica - August 17, 2022 Category: Hematology Source Type: research

Childhood Arterial Ischaemic Stroke: Clinical Presentation, Risk Factors and Management.
Abstract Childhood arterial ischaemic stroke (AIS) is a rare, but potentially life-threatening event which requires early diagnosis and adequate treatment. The reported significant time delay to childhood AIS diagnosis may be associated with low awareness, the more nonspecific clinical presentation as well as difficult clinical differentiation to more common "stroke mimics" and a less established "acute care structure" with delayed access to proper neuroimaging. Compared with adult stroke care, experiences with acute reperfusion therapies like thrombolysis and mechanical thrombectomy are promising but limited and ...
Source: Hamostaseologie - April 22, 2020 Category: Hematology Authors: Gerstl L, Bonfert MV, Heinen F, Olivieri M, Schroeder AS, Tacke M, Kurnik K, Bidlingmaier C, Reiter K, Borggraefe I Tags: Hamostaseologie Source Type: research

Association of education and feedback on hypertension management with risk for stroke and cardiovascular disease
CONCLUSIONS: This study does not support an association between education and feedback on hypertension management to primary care physicians and the risk for stroke or cardiovascular outcomes. The observed differences for mortality outcomes should be interpreted with caution.PMID:35179089 | DOI:10.1080/08037051.2022.2041393
Source: Blood Pressure - February 18, 2022 Category: Hematology Authors: Mattias Brunstr öm Nawi Ng John Dahlstr öm Lars H Lindholm Margareta Norberg Lennarth Nystr öm Lars Weinehall Bo Carlberg Source Type: research

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