• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Immediately After A Stroke, Your Next Steps Are Crucial
By Shereen Lehman (Reuters Health) - Time is critical when someone has a stroke, but care can be delayed when victims, bystanders or even health workers don't recognize the emergency, a new study in the UK finds. Better public awareness of the signs of stroke and the importance of seeking immediate emergency care are needed, the authors say. Stroke signs include the sudden onset of various symptoms such as confusion, difficulty speaking, droopy face or slurred speech, weakness in a limb, numbness, being off-balance, visual loss or a really severe headache. "Getting to hospital quickly is...
Source: Science - The Huffington Post - December 12, 2014 Category: Science Source Type: news

Stop-smoking program extended at Milwaukee Heart Institute
The University of Wisconsin-Madison's stop-smoking initiative will extend its offer of free testing, coaching and medications at Aurora Sinai Medical Center’s Milwaukee Heart Institute on Jan. 2. UW was awarded a $10 million grant in 2011 for the university’s second Wisconsin Smokers Health Study. The grant was from the National Heart Lung and Blood Institute, Bethesda, Md. The program provides free artery scans that can signal impending risk of a stroke or heart attack. Participants also get…
Source: bizjournals.com Health Care:Physician Practices headlines - December 31, 2012 Category: American Health Authors: Rich Kirchen Source Type: research