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Characterization of Parkinson ’s disease using blood-based biomarkers: A multicohort proteomic analysis
ConclusionsIn this study, we found that the blood-based biomarkers BSP, OMD, ACY1, and GHR robustly associated with PD across multiple clinical sites. Our findings suggest that biomarkers based on a peripheral blood sample may be developed for both disease characterization and prediction of future disease progression in PD.
Source: PLoS Medicine - October 10, 2019 Category: Internal Medicine Authors: Marijan Posavi Source Type: research

Long-term Outcomes of Parkinson's Disease Patients with Normal Cognition. (P5.260)
Conclusion:More than one-third of PD patients with NC develop cognitive impairment within 4 years, and the majority of new MCI cases convert to dementia within 3 years. Worse executive, language and memory abilities all predict future decline. These results are consistent with previous studies reporting that the overwhelming majority of PD patients develop cognitive impairment long-term, and have implications for understanding disease course and clinical care.Disclosure: Dr. Pigott has nothing to disclose. Dr. Rick has nothing to disclose. Dr. Hurtig has nothing to disclose. Dr. Chen-Plotkin has received research support f...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pigott, K., Rick, J., Hurtig, H., Chen-Plotkin, A., Duda, J., Morley, J., Chahine, L., Dahodwala, N., Fleisher, J., Akhtar, R., Siderowf, A., Goldmann Gross, R., Xie, S., Trojanowski, J., Weintraub, D. Tags: Movement Disorders: Cognition and Parkinson ' s Disease Source Type: research

Mild Parkinsonian Signs Are a Risk Factor for Falls (P3.084)
CONCLUSIONS: MPS is a significant risk factor for falls. Early detection of this risk factor state is important in order to implement early fall prevention programs among primary care patients.Study Supported by: NIH/NIA K23AG034236Disclosure: Dr. Dahodwala has received research support from Teva Neuroscience. Dr. Nwadiogbu has nothing to disclose. Dr. Fitts has nothing to disclose. Dr. Partridge has nothing to disclose. Dr. Karlawish has received personal compensation in an editorial capacity for the Journal of the American Geriatrics Society. Dr. Karlawish has received license fee payments.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dahodwala, N., Nwadiogbu, C., Fitts, W., Partridge, H., Karlawish, J. Tags: Movement Disorders: Other Parkinsonian Disorders Source Type: research

Neuropsychologic assessment in collaborative Parkinson’s disease research: A proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson’s Disease Research at the University of Pennsylvania and the University of Washington
Abstract: Cognitive impairment (CI) and behavioral disturbances can be the earliest symptoms of Parkinson's disease (PD), ultimately afflict the vast majority of PD patients, and increase caregiver burden. Our two Morris K. Udall Centers of Excellence for Parkinson's Disease Research were supported by the National Institute of Neurological Disorders and Stroke (NINDS) in an effort to recommend a comprehensive yet practical approach to cognitive and behavioral assessment to further collaborative research. We recommend a stepwise approach with two levels of standardized evaluation to establish a common battery, as well as an...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 19, 2012 Category: Geriatrics Authors: G. Stennis Watson, Brenna A. Cholerton, Rachel G. Gross, Daniel Weintraub, Cyrus P. Zabetian, John Q. Trojanowski, Thomas J. Montine, Andrew Siderowf, James B. Leverenz Tags: Perspectives Source Type: research