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Heat Shock Protein A12A Encodes a Novel Prosurvival Pathway during Ischaemic Stroke.
This study investigated the effects of HSPA12A on ischaemic stroke in mice. Ischaemic stroke was induced by left middle cerebral artery occlusion for 1 h followed by blood reperfusion. We observed that HSPA12A was highly expressed in brain neurons, and neuronal HSPA12A expression was downregulated by ischaemic stroke and stroke-associated risk factors (aging, obesity and hyperglycaemia). To investigate the functional requirement of HSPA12A in protecting ischaemic brain injury, HSPA12A knockout mice (Hspa12a-/-) were generated. Hspa12a-/- mice exhibited an enlarged infarct volume and aggravated neurological deficits compare...
Source: Biochimica et Biophysica Acta - March 9, 2018 Category: Biochemistry Authors: Mao Y, Kong Q, Li R, Zhang X, Gui Y, Li Y, Li C, Zhao Y, Liu L, Ding Z Tags: Biochim Biophys Acta Source Type: research

Magnetic resonance spectroscopy of the ischemic brain under lithium treatment. Link to mitochondrial disorders under stroke
In this study we evaluated partial metabolic pathways under the simulation of a stroke by using the occlusion of the middle cerebral artery in rats. The analysis shows that the induced switch to a non-oxidative energy metabolism (glycolysis) due to the block of tissue oxygen supply does not ensure the adequate supply of the tissue with ATP. Moreover, the well-known acidification of the ischemic tissue is not associated with the so-called traditionally and incorrectly considered “lactic acidosis” (the generation of lactate from glucose by itself does not lead to excessive generation of protons), but occurs because of th...
Source: Chemico Biological Interactions - June 24, 2015 Category: Biochemistry Source Type: research