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Drug: Lithium

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Total 72 results found since Jan 2013.

Short-term lithium treatment protects the brain against ischemia-reperfusion injury by enhancing the neuroplasticity of cortical neurons
CONCLUSION: Our study confirmed that neuroplasticity in cortical neurons is crucial for lithium-induced brain function 50 recovery after brain ischemia.PMID:34396932 | DOI:10.1080/01616412.2021.1965427
Source: Neurological Research - August 16, 2021 Category: Neurology Authors: Shih-Huang Tai Liang-Chun Chao Tung-Yi Huang Che-Chao Chang Sheng-Yang Huang Tian-Shung Wu E-Jian Lee Source Type: research

In the Kingdom of Triphasic Waves, White Matter Is the Eminence Grise
Conclusions: This is the first series to demonstrate convincingly the presence of TWs in patients with WMD in the absence of commonly cited risk factors. The authors hypothesize that less recognized risk factors of WMD and mild metabolic or infectious abnormalities may be drivers of TWs. With a growing elderly population, the presence of WMD will increase, and treating physicians need to look beyond the common causes of TWs.
Source: Journal of Clinical Neurophysiology - November 1, 2021 Category: Neurology Tags: Original Research Source Type: research

Determination of 18 Trace Elements in 10 Batches of the Tibetan Medicine Qishiwei Zhenzhu Pills by Direct Inductively Coupled Plasma-Mass Spectrometry
Evid Based Complement Alternat Med. 2022 Jan 13;2022:8548378. doi: 10.1155/2022/8548378. eCollection 2022.ABSTRACTQishiwei Zhenzhu pills (QSW) was first recorded in the Tibetan medicine classic Si Bu Yi Dian and has been used to treat "Baimai" disease, stroke, paralysis, hemiplegia, cerebral hemorrhage, and other diseases till today. This prescription contains more than 70 medicines including myrobalan, pearl, agate, opal, bezoar, coral, musk, gold, silver, and a mineral mixture Zuotai. As a result, QSW contains a large amount of mercury, copper, lead, and other trace elements. The aim of this study was to determine the 18...
Source: Evidence-based Complementary and Alternative Medicine - January 24, 2022 Category: Complementary Medicine Authors: Ke Fu Yinglian Song Dewei Zhang Min Xu Ruixia Wu Xueqing Xiong Xianwu Liu Lei Wu Ya Guo You Zhou Xiaoli Li Zhang Wang Source Type: research

Lithium upregulates growth-associated protein-43 (GAP-43) and postsynaptic density-95 (PSD-95) in cultured neurons exposed to oxygen-glucose deprivation and improves electrophysiological outcomes in rats subjected to transient focal cerebral ischemia following a long-term recovery period
CONCLUSION: Lithium upregulates BDNF, GAP-43, and PSD-95, which partly accounts for its improvement of neuroplasticity and provision of long-term neuroprotection in the ischemic brain.Abbreviations: BDNF: brain-derived neurotrophic factor; ECM: extracellular matrix; EDTA: ethylenediaminetetraacetic acid; GAP-43: growth-associated protein-43; GSK-3β: glycogen synthase kinase-3β; HBSS: Hank's balanced salt solution; LCBF: local cortical blood perfusion; LDF: laser-Doppler flowmetry; MCAO: middle cerebral artery occlusion; MMP: matrix metalloproteinase; NMDA: N-methyl-D-aspartate; NMDAR: N-methyl-D-aspartate receptor; OCT: ...
Source: Neurological Research - March 29, 2022 Category: Neurology Authors: Shih-Huang Tai Sheng-Yang Huang Liang-Chun Chao Yu-Wen Lin Chien-Chih Huang Tian-Shung Wu Yan-Shen Shan Ai-Hua Lee E-Jian Lee Source Type: research

Low-dose 7,8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy Development
AbstractTemporal lobe epilepsy often manifests months or even years after an initial epileptogenic insult (e.g., stroke, trauma, status epilepticus) and, therefore, may be preventable. However, no such preventive treatment is currently available. Aim of this study was to test an antioxidant agent, 7,8-dihydroxyflavone (7,8-DHF), that is well tolerated and effective in preclinical models of many neurological disorders, as an anti-epileptogenic drug. However, 7,8-DHF also acts as a TrkB receptor agonist and, based on the literature, this effect may imply an anti- or a pro-epileptogenic effect. We found that low- (5  mg/kg),...
Source: Neurotherapeutics - September 30, 2022 Category: Neurology Source Type: research

Risks and Benefits of Current and Novel Drugs to Treat Agitation in Alzheimer's Disease
Expert Opin Drug Saf. 2022 Oct 17. doi: 10.1080/14740338.2022.2136162. Online ahead of print.ABSTRACTINTRODUCTION: At present, no pharmacological interventions have been approved for the treatment of agitation in Alzheimer's disease (AD), an important neuropsychiatric symptom that has been linked to increased mortality and greater caregiver burden. Antipsychotics offer some benefit, but increase the risk of adverse events such as falls, extrapyramidal symptoms, stroke, and mortality. Over the past 10 years, several new and repurposed medications have shown promise for treating AD-associated agitation.AREAS COVERED: We revi...
Source: Expert Opinion on Drug Safety - October 17, 2022 Category: Drugs & Pharmacology Authors: Nathan Herrmann Hui Jue Wang Ella Bing Xin Song Kritleen K Bawa Krista L Lanct ôt Source Type: research

COVID-19 Continuous-EEG Case Series: A Descriptive Study
Conclusions: In this observational case series of 16 patients with COVID-19 who were monitored with continuous video-EEG, most patients experienced a nonspecific encephalopathy. Clinical seizures and electrographic status epilepticus were the second most commonly observed neurological problem.
Source: Journal of Clinical Neurophysiology - November 1, 2022 Category: Neurology Tags: Original Research Source Type: research