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Source: Journal of Stroke and Cerebrovascular Diseases
Drug: Insulin
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Total 19 results found since Jan 2013.
Post-stroke cognitive impairment and the risk of stroke recurrence and death in patients with insulin resistance
Post-stroke cognitive impairment (PSCI) is associated with etiology, severity, and functional outcome of stroke. The risks of recurrent stroke and death in patients with PSCI and insulin resistance (IR) is unknown. The goal of this study was to determine whether global and domain-specific cognitive impairment after stroke in patients with IR was associated with recurrent stroke and death.
Source: Journal of Stroke and Cerebrovascular Diseases - August 27, 2022 Category: Neurology Authors: Kat Schmidt, Melinda C. Power, Adam Ciarleglio, Zurab Nadareishvili, IRIS Study Group Source Type: research
Central vs site outcome adjudication in the IRIS trial
Central adjudication of outcome events is the standard in clinical trial research. We examine the benefit of central adjudication in the Insulin Resistance Intervention after Stroke (IRIS) trial and show how the benefit is influenced by outcome definition and features of the adjudicated events.
Source: Journal of Stroke and Cerebrovascular Diseases - July 25, 2022 Category: Neurology Authors: Rachel Forman, Catherine M. Viscoli, Philip M. Bath, Karen L. Furie, Peter Guarino, Silvio E. Inzucchi, Lawrence Young, Walter N. Kernan Source Type: research
Potential Application of Intranasal Insulin Delivery for Treatment of Intracerebral Hemorrhage: A Review of The Literature
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke associated with high morbidity and mortality that is considered a medical emergency, mainly managed with adequate blood pressure control and creating a favorable hemostatic condition. However, to date, none of the randomized clinical trials have led to an effective treatment for ICH. It is vital to better understand the mechanisms underlying brain injury to effectively decrease ICH-associated morbidity and mortality. It is well known that initial hematoma formation and its expansion have detrimental consequences.
Source: Journal of Stroke and Cerebrovascular Diseases - April 27, 2022 Category: Neurology Authors: Muhammad Ali Javaid, Magdy Selim, Santiago Ortega-Gutierrez, Simona Lattanzi, Shima Zargar, Danielle A Alaouieh, Emily Hong, Afshin A. Divani Tags: Review Article Source Type: research
Positive Association Between Serum Insulin-Like Growth Factor-1 and Cognition in Patients with Cerebral Small Vessel Disease
Cognitive impairment is one of the main complications of cerebral small vessel disease (CSVD). Serum insulin-like growth factor-1 (IGF-1) might serve as a marker for the risk of cognitive decline in patients with CSVD. We investigated the association of IGF-1 with the development of cognitive impairment in patients with CSVD. We included 216 patients with CVSD (mean age, 67.57 ± 8.53 years; 31.9% female). We compared 117 (54.2%) patients who developed cognitive impairment with 99 (45.8%) patients without cognitive impairment.
Source: Journal of Stroke and Cerebrovascular Diseases - April 17, 2021 Category: Neurology Authors: Jingwen Kang, Wenqiu Luo, Cuiwei Zhang, Yi Ren, Liping Cao, Jian Wu, Huajie Li Source Type: research
Insulin Resistance is Significantly Related with Worse Clinical Outcomes in Non-Diabetic Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
to investigate the relationship between insulin resistance (IR) and clinical outcomes in non-diabetic ischemic stroke patients treated with intravenous thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2020 Category: Neurology Authors: Xiaoli Yang, Chen Li, Jing Li, Duanlu Hou, Yufan Luo, Shufan Zhang, Zhi Jin, Liwei Shen, Ping Zhong, Danhong Wu Source Type: research
Longitudinal Relationship Between Intramuscular Fat in the Quadriceps and Gait Independence in Convalescent Stroke Patients
In stroke patients, secondary changes in the skeletal muscles, including decreased muscle mass and increased intramuscular fat, have been examined after stroke onset.1 These changes are greater on the paretic side than on the non-paretic side.2,3 In chronic stroke survivors, these secondary changes in skeletal muscles are associated with decreased muscle strength,4 gait independence,5 and aerobic exercise capacity.6 Furthermore, Ryan et al.2 have reported that increased intramuscular fat in stroke patients is associated with decreased insulin sensitivity.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2020 Category: Neurology Authors: Taisei Ishimoto, Yusuke Taniguchi, Naoki Akazawa Source Type: research
Insulin-Like Growth Factor 2 (IGF-2) Regulates Neuronal Density and IGF-2 Distribution Following Hippocampal Intracerebral Hemorrhage
Memory is the most critical cognitive function in humans. Hippocampus infarcts and artery lesions in stroke and trauma cause levels of memory loss, and it is an apparent cause of disability in the communities.1,2 Intracerebral Hemorrhage (ICH) caused by bleeding in the brain parenchyma and penetration of the hematoma into the hippocampus leads to severe memory damage.3,4 Many arteries supply the hippocampus, most of which branch off of the posterior cerebral artery, the anterior temporal, and the anterior choroidal arteries.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Farzaneh Vafaee, Asadollah Zarifkar, Masoumeh Emamghoreishi, Mohammad Reza Namavar, Shima Shirzad, Hamed Ghazavi, Vahid Mahdavizadeh Source Type: research
Microembolic Signals is Associated With Insulin Resistance Among Acute Ischemic Stroke Patients
This study aims to investigate the clinical correlation between intracranial MES and IR in AIS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Xuyou Zhou, Dongmei Zhang, Yong Zhou, Fang Wang, Xiangyang Zhu Source Type: research
Resistive Training and Molecular Regulators of Vascular-Metabolic Risk in Chronic Stroke
Peroxisome proliferator-activated receptor (PPAR)- γ coactivator (PGC-1α) gene and Sirtuin-1 (SIRT-1) respond to physiological stimuli and regulate insulin resistance. Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and the soluble forms of intracellular adhesion molecule (sICAM-1) and vas cular CAM-1 (sVCAM-1) are associated with increased risk of diabetes and coronary heart disease. Resistive training (RT) reduces hyperinsulinemia and improves insulin action in chronic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2016 Category: Neurology Authors: Alice S. Ryan, Guoyan Li, Charlene Hafer-Macko, Frederick M. Ivey Source Type: research
Decrease in Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-1 Ratio in the First Week of Stroke Is Related to Positive Outcomes
High insulin-like growth factor-1 (IGF-1), measured once during acute stroke, is associated with greater survival rates and lower stroke severity. However, information is lacking regarding how IGF-1 availability, determined by IGF-1's ratio to insulin-like growth factor binding protein-3 (IGFBP-3), relates to recovery and how the response of IGF-1 during the first week of stroke relates to outcomes. The purpose of this study was to determine the following: (1) the relationship between percent change in IGF-1 and IGF-1 ratio during the first week of stroke and stroke outcomes; and (2) the difference in percent change in IGF...
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2016 Category: Neurology Authors: Anna E. Mattlage, Michael A. Rippee, Janice Sandt, Sandra A. Billinger Source Type: research
A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack
We sought to develop an instrument to screen for insulin resistance in nondiabetic patients with recent ischemic stroke or transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2016 Category: Neurology Authors: Jin Xu, Catherine M. Viscoli, Gary A. Ford, Mark Gorman, Walter N. Kernan, IRIS Trial Investigators Source Type: research
Neurovascular Protection by Telmisartan via Reducing Neuroinflammation in Stroke-Resistant Spontaneously Hypertensive Rat Brain after Ischemic Stroke
We examined the effects of telmisartan on neurovascular unit (N-acetylglucosamine oligomer [NAGO], collagen IV, and glial fibrillary acidic protein [GFAP]) and neuroinflammation (matrix metalloproteinase-9 [MMP-9] and inflammasome) in brain of stroke-resistant spontaneously hypertensive rat (SHR-SR). At 12 weeks of age, SHR-SR received transient middle cerebral artery occlusion (tMCAO) for 90 minutes and were divided into the following 3 groups, that is, vehicle group, low-dose telmisartan group (.3 mg/kg/d), and high-dose telmisartan group (3 mg/kg/d, postoral).
Source: Journal of Stroke and Cerebrovascular Diseases - December 19, 2014 Category: Neurology Authors: Syoichiro Kono, Tomoko Kurata, Kota Sato, Yoshio Omote, Nozomi Hishikawa, Toru Yamashita, Kentaro Deguchi, Koji Abe Source Type: research
Long-term Amelioration of Telmisartan on Metabolic Syndrome-related Molecules in Stroke-resistant Spontaneously Hypertensive Rat after Transient Middle Cerebral Artery Occlusion
We examined the effects of telmisartan on metabolic syndrome-related molecules such as insulin receptor (IR), peroxisome proliferator-activated receptor gamma (PPAR-γ), and angiotensin 2 type 1 receptor (AT1R) in stroke-resistant spontaneously hypertensive rat (SHR-SR) after transient middle cerebral artery occlusion (tMCAO), by administering telmisartan at either 0 (vehicle), .3 mg/kg/day (low dose), or 3 mg/kg/day (high dose), postoperatively, from 3 months of age and performed immunohistologic analysis at 6, 12, and 18 months of age.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2014 Category: Neurology Authors: Kentaro Deguchi, Tomoko Kurata, Yusuke Fukui, Wentao Liu, Zhai Yun, Yoshio Omote, Kota Sato, Syoichiro Kono, Nozomi Hishikawa, Toru Yamashita, Koji Abe Source Type: research
