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Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Current approaches to enhance glutamate transporter function and expression
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - June 20, 2015 Category: Neurology Authors: Andréia C. K. Fontana Tags: Review Source Type: research

GLT-1 transporter: An effective pharmacological target for various neurological disorders
Publication date: Available online 13 October 2014 Source:Pharmacology Biochemistry and Behavior Author(s): Neha Soni , B.V.K. Reddy , Puneet Kumar l-Glutamate is the predominant excitatory neurotransmitter in the central nervous system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate is released in the synaptic cleft at a particular concentration that further activates the various glutaminergic receptors. This concentration of glutamate in the synapse is maintained by either glutamine synthetase or excitatory amino acid proteins which reuptake the excessive glutamate from the syna...
Source: Pharmacology Biochemistry and Behavior - November 6, 2014 Category: Biochemistry Source Type: research