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Pharmacotherapy to Manage Central Post-Stroke Pain
AbstractCentral post-stroke pain is a chronic neuropathic pain syndrome following a cerebrovascular accident. The development of central post-stroke pain is estimated to occur in 8 to 55% of stroke patients and is described as constant or intermittent neuropathic pain accompanied by dysesthesia of temperature and/or pressure sensations. These pain and sensory deficits are within the area of the body corresponding to the stroke lesion. The onset of pain is usually gradual, though it can develop either immediately after stroke or years after. Given the diversity in its clinical presentation, central post-stroke pain is a cha...
Source: CNS Drugs - February 7, 2021 Category: Neurology Source Type: research

Brain activity changes in a monkey model of central post-stroke pain.
Abstract Central post-stroke pain (CPSP) can occur after stroke in the somatosensory pathway that includes the posterolateral region of the thalamus. Tactile allodynia, in which innocuous tactile stimuli are perceived as painful, is common in patients with CPSP. Previous brain imaging studies have reported plastic changes in brain activity in patients with tactile allodynia after stroke, but a causal relationship between such changes and the symptoms has not been established. We recently developed a non-human primate (macaque) model of CPSP based on thalamic lesions, in which the animals show behavioral changes co...
Source: Experimental Neurology - October 31, 2019 Category: Neurology Authors: Nagasaka K, Takashima I, Matsuda K, Higo N Tags: Exp Neurol Source Type: research

Treatment of status migrainosus by general anesthesia: a case report
Conclusion Status migrainosus is a rare disabling complication and anesthetics have been the subject of research in its treatment; the option for general anesthesia with agents that stimulate GABA receptors, propofol and isoflurane, in association with fentanyl, proved effective and should encourage new research.
Source: Brazilian Journal of Anesthesiology - August 29, 2015 Category: Anesthesiology Source Type: research

A Pilot Study for a Prospective, Randomized, Double-Blind Trial of the Influence of Anesthetic Depth on Long-Term Outcome.
CONCLUSIONS:: This pilot study demonstrated that depth of anesthesia targeting with BIS or SE was achievable in a high-risk population with adequate separation of processed electroencephalogram monitor targets. The expected incidence of postoperative complications and mortality occurred. We conclude that a large, multicenter, randomized controlled trial is feasible. PMID: 24781568 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - May 1, 2014 Category: Anesthesiology Authors: Short TG, Leslie K, Campbell D, Chan MT, Corcoran T, O'Loughlin E, Frampton C, Myles P Tags: Anesth Analg Source Type: research