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Degeneration of paramedian nuclei in the thalamus induces Holmes tremor in a case of artery of Percheron infarction
Abstract Rationale: Holmes’ tremor is an uncommon neurologic disorder following brain insults, and its pathogenesis is undefined. The interruption of the dento-rubro-thalamic tract and secondary deterioration of the nigrostriatal pathway are both required to initiate Holmes’ tremor. We used nuclear medicine imaging tools to analyze a patient with concurrent infarction in different zones of each side of the thalamus. Finding whether the paramedian nuclear groups of the thalamus were injured was a decisive element for developing Holmes’ tremor. Patient concerns: A 36-year-old woman was admitted to our department d...
Source: Medicine - November 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults.
Abstract Primary motor cortex (M1) plasticity is involved in motor learning and stroke motor recovery, and enhanced by increasing monoaminergic transmission. Age impacts these processes but there is a paucity of systematic studies on the effects of monoaminergic drugs in older adults. Here, in ten older adults (age 61+ 4 years, 4 males), we determine the effects of a single oral dose of carbidopa/levodopa (DOPA), d-amphetamine (AMPH), methylphenidate (MEPH) and placebo (PLAC) on M1 excitability and motor training-induced M1 plasticity. M1 plasticity is defined as training related long lasting changes in M1 excitab...
Source: Brain Research - June 17, 2017 Category: Neurology Authors: Kesar TM, Belagaje SR, Pergami P, Haut MW, Hobbs G, Buetefisch CM Tags: Brain Res Source Type: research

Combining levodopa and virtual reality-based therapy for the rehabilitation of upper limb after acute stroke: pilot study part II.
CONCLUSION: Our results suggest that VR-based therapy and pharmacotherapy may be combined for acute stroke rehabilitation. The bedside acquisition of kinematic measurements allows for an accurate assessment of the quality of limb movement, offering a sensitive clinical tool for quantifying motor recovery during the rehabilitation process after acute stroke. PMID: 27311739 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - June 16, 2016 Category: Journals (General) Authors: Samuel GS, Oey NE, Choo M, Ju H, Chan WY, Kok S, Ge Y, Van Dongen AM, Ng YS Tags: Singapore Med J Source Type: research

L-dopa does not add to the success of high-intensity language training in aphasia.
CONCLUSION: High-intensity language training in chronic aphasia may take learning to a ceiling that precludes additive benefits from l-dopa. Effects of l-dopa on post-stroke recovery during less intense treatment in chronic aphasia remain to be evaluated. PMID: 25588456 [PubMed - indexed for MEDLINE]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Role, indications and controversies of levodopa administration in chronic stroke patients.
Abstract Stroke leaves many patients disabled even after rehabilitative training, representing a major cause of disability. Several approaches to improve outcomes have been attempted in recent years, with only relative benefit. Emerging evidences show a potential role of pharmacological intervention to enhance motor recovery after stroke. Contrasting evidence are coming from experimental and clinical studies, so far, and pharmacological intervention during rehabilitation represents a major controversial in neurorehabilitation. Dopaminergic stimulation appears as one of the most promising way to improve motor recov...
Source: European Journal of Physical and Rehabilitation Medicine - April 5, 2013 Category: Rehabilitation Authors: Acler M, Manganotti P Tags: Eur J Phys Rehabil Med Source Type: research