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Presentation of atrial fibrillation following oral dexamethasone treatment in a NF2 patient
Atrial fibrillation (A-fib) is the most common cardiac arrhythmia which is associated with an increased risk of mortality secondary to stroke and coronary artery disease. Intravenous glucocorticoid therapy (such as dexamethasone and hydrocortisone) is frequently used peri-operatively in patients undergoing cardiac surgery to prevent A-fib. Dexamethasone is also frequently used in patients with single or bilateral vestibular schwannomas (VS), to reduce tumor swelling both before and after radiation treatment.
Source: American Journal of Otolaryngology - May 2, 2014 Category: Endocrinology Authors: Andrea L.O. Hebb, Syed Ali Imran, David P. Morris, Manohar Bance, Simon Walling Tags: Case report Source Type: research

Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism
Publication date: Available online 4 November 2014 Source:Neurochemistry International Author(s): Meiling Sun , Mei Li , Qiao Huang , Feng Han , Jin-hua Gu , Jiaming Xie , Rong Han , Zheng-Hong Qin , Zhipeng Zhou We previously found that TIGAR (TP53-induced glycolysis and apoptosis regulator) was upregulated in response to ischemia/reperfusion insult in a TP53-independent manner. The present study sought to investigate the regulatory mechanisms of TIGAR upregulation in animal and cellular models of stroke. The animal and cellular models of ischemia/reperfusion were produced by transient middle cerebral artery occlusion a...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research

New recommendations aim to improve safety of pain-relieving spinal steroid injections
More and more people are seeking injections of anti-inflammatory steroid medications for back and neck pain. In 2011, the last year for which complete information is available, doctors pushed the plunger on 2.3 million steroid injections into the spine — and that’s just among people covered by Medicare. These injections deliver drugs that mimic the effects of two hormones, cortisone and hydrocortisone, to reduce inflammation and help relieve pain. When they work — they don’t always — such injections can bring profound relief. “If you are in severe pain with a ruptured spinal disc and you get a stero...
Source: New Harvard Health Information - May 7, 2015 Category: Consumer Health News Authors: Daniel Pendick Tags: Back Pain Drugs and Supplements anti-inflammatory steroid medications spinal injections spine steroid injections Source Type: news

Combined use of high doses of vasopressin and corticosteroids in a patient with Crohn ’s disease with refractory septic shock after intestinal perforation: a case report
ConclusionsThe significant increase in her cardiac index and stroke volume index resulted in an improvement in peripheral resistance, gas exchange, and urine output and a decrease in her heart rate, interleukin-6 level, and tumor necrosis factor- α level. The administration of high doses of vasopressin and corticosteroids was demonstrated to be safe for the immune system, to reduce the systemic inflammatory response, and to have direct cardiovascular effects. Further studies are required to examine the use of vasopressin as an initial vasop ressor as well as its use in high dosages and in combination with corticosteroids.
Source: Journal of Medical Case Reports - November 13, 2017 Category: General Medicine Source Type: research

Epidemiology and Comorbidity of Adrenal Cushing Syndrome: A Nationwide Cohort Study
CONCLUSIONS: Adrenal CS is associated with multiple comorbidities even after treatment, which necessitates meticulous postoperative care.PMID:34932806 | DOI:10.1210/clinem/dgaa752
Source: The Journal of Clinical Endocrinology and Metabolism - December 21, 2021 Category: Endocrinology Authors: Chang Ho Ahn Jung Hee Kim Man Young Park Sang Wan Kim Source Type: research

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