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Low-dose nifedipine rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice
In conclusion, low-dose nifedipine can enhance EPCs' angiogenic potential and protect against cerebral ischemic injury in diabetic mice. It is implied that chronic treatment with low-dose nifedipine may be a safe and economic manner to prevent ischemic diseases (including stroke) in diabetes.PMID:35882957 | DOI:10.1038/s41401-022-00948-w
Source: Acta Pharmacologica Sinica - July 26, 2022 Category: Drugs & Pharmacology Authors: Cheng Peng Li-Jun Yang Chuan Zhang Yu Jiang Liu-Wen-Xin Shang Jia-Bei He Zhen-Wei Zhou Xia Tao Lu Tie Alex F Chen He-Hui Xie Source Type: research

Effect Western Medicines Combined With Nao-Xue-Shu in Patients With Hypertensive Intracerebral Hemorrhage: A Network Meta-Analysis
Conclusion: Nao-Xue-Shu combined with nifedipine showed better effectiveness after treatment in HICH patients compared with the other combinations. Nao-Xue-Shu combined with EDA was more effective for improving neurological function and reducing both hematoma and edema volumes around the hematoma compared with the other combinations. However, Nao-Xue-Shu alone or Nao-Xue-Shu combined with nimodipine may be more effective for reducing proinflammatory factor expression.
Source: Frontiers in Pharmacology - June 15, 2022 Category: Drugs & Pharmacology Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Emodin accentuates atrial natriuretic peptide secretion in cardiac atria.
Abstract Emodin, an active anthraquinone constituent isolated from the rhubarb, a traditional Chinese herbal medicine which is widely used in clinical treatment, has cardiovascular protective properties. However, it remains unclear whether the cardiovascular protective actions of emodin are related to an activation of cardiac natriuretic hormone secretion. The purpose of the present study was to explore the effect of emodin on the secretion of ANP, a member of the family of cardiac natriuretic hormones, and its mechanisms involved. Experiments were performed in isolated perfused beating rabbit atria allowing measu...
Source: European Journal of Pharmacology - April 18, 2014 Category: Drugs & Pharmacology Authors: Hai Zhou G, Zhang F, Nong Wang X, Jeong Kwon O, Gill Kang D, Sub Lee H, Nan Jin S, Woo Cho K, Fu Wen J Tags: Eur J Pharmacol Source Type: research