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Specialty: Neurosurgery
Drug: Clopidogrel

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Total 40 results found since Jan 2013.

Review of Toyoda K, et al. Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischemic stroke in Japan. Lancet Neurol. 2019 Jun;18(6):539-548.
Conclusion: This RCT demonstrated the safety of dual therapy, consisting of cilostazol/aspirin or cilostazol/ clopidogrel, in preventing secondary ischemic stroke in a high-risk Japanese population. Further studies are required to generalize these findings to other patient populations worldwide. PMID: 32363048 [PubMed]
Source: Surgical Neurology International - May 5, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

E-020 Between a Rock and a Hard Place: The Use of Self-expanding Stents for the Endovascular Treatment of Acute Ischemic Stroke due to Recalcitrant Emergency Large Vessel Occlusion in the Era of Stent-retrievers: Single-center Experience and Early Results
ConclusionInitial results suggest that acute intracranial stenting may be beneficial in a subset of patients who present with an ELVO and who have failed recanalization by means of mechanical thrombectomy with stent-retrievers and/or thromboaspiration with large bore intracranial catheters.DisclosuresJ. Lozano: None. M. Howk: None. A. Kuhn: None. F. Massari: None. K. de Macedo Rodrigues: None. C. Brooks: None. M. Perras: None. M. Gounis: 1; C; NIH, Medtronic Neurovascular, Microvention/Terumo, Cerevasc LLC, Gentuity, Codman Neurovascular, Phillips Healthcare, Stryker Neurovascular, Tay Sachs Foundation, InNeuroCo Inc. 2; C...
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Lozano, J., Howk, M., Kuhn, A., Massari, F., de Macedo Rodrigues, K., Brooks, C., Perras, M., Gounis, M., Rex, D., Wakhloo, A., Puri, A. Tags: Electronic poster abstracts Source Type: research

E-004 Focal intracranial vasculopathy as a manifestation of COVID-19-associated acute ischemic stroke
ConclusionTo our knowledge, our case is the first to illustrate the potential for COVID-19 infection to present as a focal intracranial vasculopathy in an otherwise healthy young-patient, resulting in acute ischemic stroke without an underlying hypercoagulable state. Rescue intracranial stenting was necessary to maintain vessel patency and restore intracranial flow.Disclosures A. Mahapatra: None. A. Witek: None. G. Toth: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Mahapatra, A., Witek, A., Toth, G. Tags: Electronic poster abstracts Source Type: research

P90 Intracranial balloon-expandable stents as rescue treatment in acute stroke secondary to atherosclerotic stenotic vessel disease: 10-year single center experience
ConclusionsEmergency application of dual antiplatelet agents and balloon-expandable stents for treatment of acute stroke secondary to intracranial atherosclerotic stenotic disease exhibits a comparably high rate of early reocclusion and low rate of good clinical outcome.ReferencesStracke CP, Fiehler J, Meyer L, et al. Emergency intracranial stenting in acute stroke: predictors for poor outcome and for complications. J AM Heart Assoc. 2020;9(5):E012795. DOI:10.1161/JAHA.119.012795 Do you have any conflict of interest to declare?: No
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Elsheikh, S., Elbaz, A., Taschner, C., Urbach, H., Niesen, W.-D. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

P005/44 Using the pEGASUS-stent with antithrombogenic properties and single antiplatelet therapy in a case of thrombectomy
IntroductionRescue stenting is used more and more in stroke cases with large-vessel-occlusion or medium-vessel-occlusion refractory to mechanical thrombectomy. The pEGASUS-stent(Phenox) represents a device which is equipped with a hydrophilic polymer coating(HPC) with antithrombogenic properties. The coating allows for implantation under single antiplatelet therapy, thus possibly reducing the risk of bleeding in acute stroke cases.Case HistoryA 79-year-old woman was rushed to emergency room due to left-sided hemiparesis and National-Institutes-of-Health-Stroke-Scale(NIHSS) of 14. Computed-tomography-image showed an occlusi...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Krug, N., Schulze-Zachau, V., Ntoulias, N., Psychogios, M. Tags: 4.3 CASE PROPOSAL - Acute ischemic stroke Source Type: research

P160/223 Acute stroke with treatment of tandem lesions under triple antiplatelet therapy: procedural saftey, stent patency and outcome at 90 days
ConclusionTL treatment under triple AP was safe in our experience, resulting in a low rate of restenosis and with favorable outcome in 92%. The influence of comorbidities on restenosis could be negligible within the described follow-up period.Disclosure of InterestPhilipp von Gottberg: Nothing to disclose.Ali Khanafer: Nothing to discloseVictoria Hellstern: Proctering for phenox GmbH.Alexandru Cimpocca: Nothing to disclose.Hans Henkes: Proctoring for phenox GmbH, Co-Founder and Co-Owner of CONTARA GmbH
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Philipp, V. G., Khanafer, A., Hellstern, V., Cimpoca, A., Bäzner, H., Henkes, H. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

Dream a little dream: an update on genetics guided therapy for stroke in australia
Conclusions The current evidence does not support pharmacogenetic guided therapy in stroke in Australia. However, a one-size fits all approach does not work and there is a definite dearth of Australian based pharmacogenetic research, which must be addressed.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Johnson, K., Haque, S., Shaffi, M. Tags: Abstracts Source Type: research

Case presentation: the dancing man from sierra leone
Discussion Making this diagnosis is challenging, as brain imaging often shows non specific changes and blood results are usually normal. CSF may reveal raised proteins and WBCs. A high index of suspicion is required to arrange a brain biopsy as this confirms the diagnosis.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Al-Rifai, M. S., Salek-Haddadi, A. Tags: Immunology (including allergy), Neuroimaging, Stroke, Radiology, Drugs: musculoskeletal and joint diseases, Vascularitis, Surgical diagnostic tests ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

P49 Intracranial stenting of atherosclerotic stenosis in patient suffering stroke by radial access
A 55-year-old man presented with acute stroke. The patient had left hemiparesis. Angiography revealed that the patient had intracarnial internal carotid artery atherosclerotic stenosis. Since both iliac arteries of the patient were occluded, we used radial access for the intervention. First of all, we performed angiography with sim 2 diagnostic catheter. We placed a 6Fr sheathed sheathless guide catheter into the common carotid artery with Amplatz rigid wire. We inserted the catheter sofia. We crossed the lesion with a microcatheter supported 0’14 inch guidewire and performed 2.0*20 mm coronary balloon dilatation. Fi...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Kilic, H. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.
CONCLUSIONS This is the first study examining genetic variants and their effects in symptomatic ICAD. Variant alleles of CYP2C19 (*2, *3, *8) were associated with lower odds of the primary and secondary composite endpoints. However, the direction of the association was opposite of what is expected based on this SNP. This may reflect an incomplete understanding of this genetic variation and its effect in symptomatic ICAD and warrants further investigations. PMID: 26587656 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 20, 2015 Category: Neurosurgery Authors: Hoh BL, Gong Y, McDonough CW, Waters MF, Royster AJ, Sheehan TO, Burkley B, Langaee TY, Mocco J, Zuckerman SL, Mummareddy N, Stephens ML, Ingram C, Shaffer CM, Denny JC, Brilliant MH, Kitchner TE, Linneman JG, Roden DM, Johnson JA Tags: J Neurosurg Source Type: research

P-010 Practice variations in addressing acute tandem carotid occlusions in emergent large vessel occlusion strokes
Conclusion For tandem occlusions with cervical ICA involvement, acute stenting with adjunctive angioplasty, is a current prevailing practice for recanalization of the extracranial ICA. There is considerable variability in antiplatelet protocols, with a slight favoring of the administration of loading doses of aspirin and clopidogrel before stent deployment. Variability is also present for anesthesia, with general anesthesia having a significant role. Disclosures S. Coffman: None. S. Trott: None. A. Alhajeri: None. J. Fraser: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Coffman, S., Trott, S., Alhajeri, A., Fraser, J. Tags: Oral Poster Abstracts Source Type: research

E-021 Safety and efficacy of a low dose eptifibatide infusion during endovascular treatment of tandem occlusions
Conclusions The low dose eptifibatide infusion resulted in a low incidence of SICH (5%) in the endovascular treatment of tandem intracranial occlusions. The infusion was not potent enough to maintain patency of the carotid artery in all patients. However, re-occlusion of the carotid artery was asymptomatic in the 4 patients where it occurred. This underscores that extracranial re-occlusion of the carotid artery is the lesser of evils compared with hemorrhagic stroke conversion. Limitations of the study include retrospective data collection, a low incidence of intravenous t-PA use, and lack of independent adjudication of an...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Roels, C., Brown, M., Janjua, R., Heck, D. Tags: Electronic Poster Abstracts Source Type: research

E-248 Postpartum vertebral artery dissections: a report of 7 cases and literature review
ConclusionA limited cohort of 33 ppVADs exist in the literature. This study contributes 7 additional cases and suggests that, despite heterogenous management of ppVAD, the resulting outcomes were favorable.Disclosures V. Lazarov: None. A. Monteiro: None. F. Almayman: None. M. Waqas: None. J. Cappuzzo: None. E. Levy: None. A. Siddiqui: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lazarov, V., Monteiro, A., Almayman, F., Waqas, M., Cappuzzo, J., Levy, E., Siddiqui, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Association between silent embolic cerebral infarction and continuous increase of P2Y12 reaction units after neurovascular stenting.
Conclusions Residual platelet reactivity after dual antiplatelet treatment measured before stenting did not predict poststenting SECI. However, the longer stent and the serial increase of PRU values after stenting were related to SECI. Continuous increase of platelet activation after endovascular procedure may be important in poststent cerebral infarction. PMID: 25036195 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - July 18, 2014 Category: Neurosurgery Authors: Kim BJ, Kwon JY, Jung JM, Lee DH, Kang DW, Kim JS, Kwon SU Tags: J Neurosurg Source Type: research

Clinical and radiological outcomes following traumatic Grade 3 and 4 vertebral artery injuries: a 10-year retrospective analysis from a Level I trauma center. The Parkland Carotid and Vertebral Artery Injury Survey.
CONCLUSIONS The majority of high-grade blunt VA injuries remain stable or are improved at final follow-up. Despite a 4% rate of radiographic worsening in the Grade 3 blunt VA injury group and a 35% recanalization rate in the Grade 4 blunt VA injury group, there were no adverse clinical outcomes associated with these radiographic changes. No cerebral infarctions were noted in the Grade 3 group. A 7% stroke rate was identified in the Grade 4 blunt VA injury group; however, this was confined to the immediate postinjury period and was associated with 100% mortality. While these data suggest that these high-grade vertebral arte...
Source: Journal of Neurosurgery - October 24, 2014 Category: Neurosurgery Authors: Scott WW, Sharp S, Figueroa SA, Eastman AL, Hatchette CV, Madden CJ, Rickert KL Tags: J Neurosurg Source Type: research