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Plasma selenium and the risk of first stroke in adults with hypertension: a secondary analysis of the China Stroke Primary Prevention Trial
CONCLUSIONS: In summary, there was a significant inverse association between plasma Se and risk of first stroke in Chinese adults with hypertension, especially among those with higher baseline folate concentrations and those with higher time-averaged SBP over the treatment period.Trial registration number: NCT00794885URL of registration: https://www.clinicaltrials.gov/ct2/show/NCT00794885?term=NCT00794885&draw=2&r.PMID:34549258 | DOI:10.1093/ajcn/nqab320
Source: The American Journal of Clinical Nutrition - September 22, 2021 Category: Nutrition Authors: Zhuo Wang Hai Ma Yun Song Tengfei Lin Lishun Liu Ziyi Zhou Yaping Wei Xiao Huang Ping Chen Chengzhang Liu Youbao Li Binyan Wang Jianping Li Yan Zhang Yong Huo Hao Zhang Xiping Xu Xianhui Qin Huiyuan Guo Source Type: research

Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive patients.
Abstract We aimed to examine whether baseline neutrophil counts affected the risk of new-onset proteinuria in hypertensive patients, and, if so, whether folic acid treatment is particularly effective in proteinuria prevention in such a setting. A total of 8,208 eligible participants without proteinuria at baseline were analyzed from the renal sub-study of the China Stroke Primary Prevention Trial (CSPPT). Participants were randomized to receive a double-blind daily treatment of 10mg enalapril and 0.8mg folic acid (n=4,101) or 10mg enalapril alone (n=4,107). The primary outcome was new-onset proteinuria, defined as...
Source: The British Journal of Nutrition - December 14, 2020 Category: Nutrition Authors: Zhang Z, Liu M, Zhang Y, Zhou C, He P, Li H, Li J, Zhang Y, Liang M, Wang B, Xu X, Wang X, Huo Y, Hou FF, Nie J, Xu X, Qin X Tags: Br J Nutr Source Type: research

Plasma retinol and the risk of first stroke in hypertensive adults: a nested case-control study.
Conclusions: Our data showed a significant inverse association between plasma retinol and the risk of first stroke among Chinese hypertensive adults. This study was registered at clinicaltrials.gov as NCT00794885. PMID: 30624586 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 9, 2019 Category: Nutrition Authors: Yu Y, Zhang H, Song Y, Lin T, Zhou Z, Guo H, Liu L, Wang B, Liu C, Li J, Zhang Y, Huo Y, Wang C, Wang X, Hou FF, Qin X, Xu X Tags: Am J Clin Nutr Source Type: research

Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT) Vitamins, minerals, and phytochemicals
Conclusions: Enalapril–folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adults. This trial was registered at clinicaltrials.gov as NCT00794885.
Source: American Journal of Clinical Nutrition - April 3, 2017 Category: Nutrition Authors: Qin, X., Li, Y., He, M., Tang, G., Yin, D., Liang, M., Wang, B., Nie, J., Huo, Y., Xu, X., Hou, F. F. Tags: Research Need: Role of Nutrition in Health Maintenance, Research Need: Role of Nutrition in Medical Management Vitamins, minerals, and phytochemicals Source Type: research

Longitudinal association between fasting blood glucose concentrations and first stroke in hypertensive adults in China: effect of folic acid intervention Cardiovascular disease risk
Conclusions: In Chinese hypertensive adults, an FBG concentration ≥7.0 mmol/L or diabetes is associated with an increased risk of first stroke; this increased risk is reduced by 34% with folic acid treatment. These findings warrant additional investigation. This trial was registered at clinicaltrials.gov as NCT00794885.
Source: American Journal of Clinical Nutrition - February 28, 2017 Category: Nutrition Authors: Xu, R. B., Kong, X., Xu, B. P., Song, Y., Ji, M., Zhao, M., Huang, X., Li, P., Cheng, X., Chen, F., Zhang, Y., Tang, G., Qin, X., Wang, B., Hou, F. F., Dong, Q., Chen, Y., Yang, T., Sun, N., Li, X., Zhao, L., Ge, J., Ji, L., Huo, Y., Li, J. Tags: Cardiovascular disease risk Source Type: research

Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT).
CONCLUSIONS: Enalapril-folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adults. This trial was registered at clinicaltrials.gov as NCT00794885. PMID: 28148501 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 31, 2017 Category: Nutrition Authors: Qin X, Li Y, He M, Tang G, Yin D, Liang M, Wang B, Nie J, Huo Y, Xu X, Hou FF Tags: Am J Clin Nutr Source Type: research

Longitudinal association between fasting blood glucose concentrations and first stroke in hypertensive adults in China: effect of folic acid intervention.
CONCLUSIONS: In Chinese hypertensive adults, an FBG concentration ≥7.0 mmol/L or diabetes is associated with an increased risk of first stroke; this increased risk is reduced by 34% with folic acid treatment. These findings warrant additional investigation. This trial was registered at clinicaltrials.gov as NCT00794885. PMID: 28122783 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 24, 2017 Category: Nutrition Authors: Xu RB, Kong X, Xu BP, Song Y, Ji M, Zhao M, Huang X, Li P, Cheng X, Chen F, Zhang Y, Tang G, Qin X, Wang B, Hou FF, Dong Q, Chen Y, Yang T, Sun N, Li X, Zhao L, Ge J, Ji L, Huo Y, Li J Tags: Am J Clin Nutr Source Type: research