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Safety and Feasibility of a Novel Transnasal Cooling Device to Induce Normothermia in Febrile Cerebrovascular Patients
ConclusionsInducing normothermia with a novel transnasal TMD appears to be safe, feasible and not associated with significant shivering. A multicenter trial testing the ability of the CoolStat to maintain normothermia for 24  h is currently underway.
Source: Neurocritical Care - July 13, 2020 Category: Neurology Source Type: research

Continuous intravenous low-dose diclofenac sodium to control a central fever after ischemic stroke in the intensive care unit: a case report and review of the literature
ConclusionsWe observed that a low-dose diclofenac sodium infusion was effective in treating fever without systemic side effects. This treatment may be suggested as an alternative to conventional antipyretic drugs, but additional clinical trials are required.
Source: Journal of Medical Case Reports - December 17, 2019 Category: General Medicine Source Type: research

N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis.
Authors: Will JS, Snyder CJ, Westerfield KL Abstract Exertional Heat Illness with associated ischemic hepatitis (IH) is a common occurrence among military trainees; however, few specific therapies exist if unresponsive to appropriate supportive measures. A 27-year-old basic combat trainee presented with altered mental status, renal insufficiency, rhabdomyolysis, and a core temp of 107.9 °F after collapsing during a run, leading to the diagnosis of heat stroke. While the patient's azotemia and creatinine kinase levels rapidly improved with aggressive intravenous hydration, transaminases continued to increase to nea...
Source: Military Medicine - March 1, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Response by de Ridder et al to Letter Regarding Article, “PAIS 2 (Paracetamol Acetaminophen in Stroke 2) Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial” Letter to the Editor
Source: Stroke - June 26, 2017 Category: Neurology Authors: Inger R. de Ridder, Diederik W.J. Dippel, H. Bart van der Worp Tags: Pharmacology, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Letters to the Editor Source Type: research

PAIS 2 (Paracetamol Acetaminophen in Stroke 2) Clinical Sciences
Conclusions—Treatment with high-dose paracetamol seemed to be safe. The effect of high-dose paracetamol on functional outcome remains uncertain. Therefore, a large trial of early treatment with high-dose paracetamol is still needed.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR2365.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Inger R. de Ridder, Heleen M. den Hertog, H. Maarten A. van Gemert, A.H.C.M.L. (Tobien) Schreuder, Annemieke Ruitenberg, E. (Lisette) Maasland, Ritu Saxena, Jordie H. van Tuijl, Ben P.W. Jansen, Renske M. Van den Berg-Vos, Frederique Vermeij, Peter J. Kou Tags: Pharmacology, Meta Analysis, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Neither nefopam nor acetaminophen can be used as post ‐operative analgesics in a rat model of ischemic stroke
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - September 30, 2016 Category: Drugs & Pharmacology Authors: Maud P étrault, Sophie Gautier, Vincent Bérézowski, Thavarak Ouk, Michèle Bastide, Olivier Pétrault, Régis Bordet Tags: Original Article Source Type: research

Fever Management Practices of Neuroscience Nurses: What Has Changed?
This study encourages the development of a stepwise approach to neuro-specific protocols for fever management. Furthermore, it shows the continuing need to promote further education and specialty training among nurses and encourage collaboration with physicians to establish best practices.
Source: Journal of Neuroscience Nursing - February 27, 2015 Category: Neuroscience Tags: Article Source Type: research

Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): Protocol for a randomized, placebo‐controlled, double‐blind clinical trial to assess the effect of high‐dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36·5°C or above
DiscussionIf high‐dose paracetamol will be proven effective, a simple, safe, and extremely cheap therapy will be available for many patients with acute stroke worldwide.
Source: International Journal of Stroke - May 22, 2013 Category: Neurology Authors: Inger R. Ridder, Frank Jan Jong, Heleen M. Hertog, Hester F. Lingsma, H. Maarten A. Gemert, A. H. C. M. L. (Tobien) Schreuder, Annemieke Ruitenberg, E. (Lisette) Maasland, Ritu Saxena, Peter Oomes, Jordie Tuijl, Peter J. Koudstaal, L. Jaap Kappelle, Ale A Tags: Protocols Source Type: research