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The Amphetamine-Enhanced Stroke Recovery (AESR) Trial: Primary Part 1 Results (S45.003)
CONCLUSIONS:The studied treatment regimen was safe. Primary results will be presented.Study Supported by:NIH-NS39934Disclosure: Dr. Goldstein has received personal compensation for activities with Pfizer Inc. Dr. Goldstein has received royalty payments from Up To Date, Henry Stewart Talks, and Quantia. Dr. Goldstein has received research support from AGA. Dr. Rabadi has nothing to disclose. Dr. Reding has received personal compensation for activities with Acorda Therapeutics as a consultant. Dr. Lennihan has nothing to disclose. Dr. Good has received personal compensation for activities with Allergan, Inc. Dr. Good has rec...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Goldstein, L., Rabadi, M., Reding, M., Lennihan, L., Good, D., Dromerick, A., Pura, J., Samsa, G. Tags: Cerebrovascular Disease and Interventional Neurology: Rehabilitation, Recovery, and Complications Source Type: research

Adult hemiparkinsonian rats do not benefit from tactile stimulation.
Abstract Tactile stimulation (TS) applied to adult rats after cortical injury (medial frontal cortex aspiration or sensorimotor pial stripping stroke model) has been previously shown to ameliorate behavioral impairments and to improve morphological parameters like dendritic length of prefrontal cortical neurons (Gibb et al. Behav Brain Res 2010;214:102-7). The purpose of this study was to examine the effect of TS on healthy and hemiparkinsonian adult rats. Therefore, the animals received TS for 14 days and 15min three times daily. At different time points rats were tested in various behavioral tests (amphetamine-i...
Source: Behavioural Brain Research - December 13, 2013 Category: Neurology Authors: Effenberg A, Klein A, Gibb R, Carroll C, Baumgärtner W, Grothe C, Ratzka A Tags: Behav Brain Res Source Type: research

Therapeutic effects of repetitive transcranial magnetic stimulation in an animal model of Parkinson's disease.
In conclusion, rTMS treatment improved motor functions and survival of DA neurons, suggesting that the neuroprotective effect of rTMS treatment might be induced by upregulation of neurotrophic/growth factors in the PD animal model. PMID: 23998987 [PubMed - as supplied by publisher]
Source: Brain Research - August 30, 2013 Category: Neurology Authors: Lee JY, Kim SH, Ko AR, Lee JS, Yu JH, Seo JH, Cho BP, Cho SR Tags: Brain Res Source Type: research

Amphetamine and post-stroke rehabilitation: indications and controversies.
Abstract There is robust evidence for amphetamine (AMPH) facilitated recovery from behavioral deficits in animal models of stroke. Following experimental lesions, numerous studies of motor, somatosensory and vision recovery show AMPH accelerates the rate of recovery when paired with relevant behavioral experience. While the experimental literature continues to mount for an AMPH effect, the translation to clinical studies has been far less clear. This is due in part to the inherent difficulty of extrapolating results in animals to humans; however, there is much controversy regarding how the basic science data is in...
Source: European Journal of Physical and Rehabilitation Medicine - April 5, 2013 Category: Rehabilitation Authors: Walker-Batson D Tags: Eur J Phys Rehabil Med Source Type: research

Adderall® (Amphetamine-Dextroamphetamine) Toxicity
This article discusses our present understanding of Adderall® intoxication and examines 3 dogs presented to our practice after ingestion of large amounts of the drug.
Source: Topics in Companion Animal Medicine - February 1, 2013 Category: Veterinary Research Authors: Kevin T. Fitzgerald, Alvin C. Bronstein Source Type: research

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