• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness.
CHRONIC ANTIHYPERTENSIVE TREATMENT IMPROVES PULSE PRESSURE BUT NOT LARGE ARTERY MECHANICS IN A MOUSE MODEL OF CONGENITAL VASCULAR STIFFNESS. Am J Physiol Heart Circ Physiol. 2015 Jul 31;:ajpheart.00288.2015 Authors: Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA Abstract Increased arterial stiffness is a common characteristic of humans with Williams-Beuren syndrome and mouse models of elastin insufficiency. Arterial stiffness is associated with multiple negative cardiovascular outcomes, including myocardial infarction, stroke and sudden death. Therefore, identifying therapeutic inter...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 31, 2015 Category: Physiology Authors: Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA Tags: Am J Physiol Heart Circ Physiol Source Type: research

Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure
Heart failure (HF) is characterized by elevated sympathetic activity and reduced parasympathetic control of the heart. Experimental evidence suggests that the increase in parasympathetic function can be a therapeutic alternative to slow HF evolution. The parasympathetic neurotransmission can be improved by acetylcholinesterase inhibition. We investigated the long-term (4 wk) effects of the acetylcholinesterase inhibitor pyridostigmine on sympathovagal balance, cardiac remodeling, and cardiac function in the onset of HF following myocardial infarction. Myocardial infarction was elicited in adult male Wistar rats. After 4 wk...
Source: AJP: Regulatory, Integrative and Comparative Physiology - October 15, 2013 Category: Physiology Authors: Lataro, R. M., Silva, C. A. A., Fazan, R., Rossi, M. A., Prado, C. M., Godinho, R. O., Salgado, H. C. Tags: Cardiovascular and Renal Integration Source Type: research

Increase in parasympathetic tone by pyridostigmine prevents ventricular dysfunction during the onset of heart failure.
Abstract Heart failure (HF) is characterized by elevated sympathetic activity and reduced parasympathetic control of the heart. Experimental evidence suggests that the increase in parasympathetic function can be a therapeutic alternative to slow HF evolution. The parasympathetic neurotransmission can be improved by acetylcholinesterase inhibition. We investigated the long term (four weeks) effects of the acetylcholinesterase inhibitor pyridostigmine on sympathovagal balance, cardiac remodeling and cardiac function in the onset of HF following myocardial infarction. Myocardial infarction was elicited in adult male ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 15, 2013 Category: Physiology Authors: Lataro RM, Silva CA, Fazan R, Rossi MA, Prado CM, Godinho RO, Salgado HC Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research