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Total 43 results found since Jan 2013.

Mitochondrial Dysfunction in Migraine
Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and migraine: (1) Biochemical evidence: Abnormal mt function translates into high intracellular penetration of Ca2+, excessive production of free radicals, and deficient oxidative phosphorylation, which ultimately causes energy failure in neurons and astrocytes, thus triggering ...
Source: Seminars in Pediatric Neurology - September 1, 2013 Category: Neurology Authors: William R. Yorns, H. Huntley Hardison Source Type: research

Well: 3 Things to Know About Niacin and Heart Health
New studies are adding to concerns about the safety and effectiveness of niacin, a popular drug for the prevention of cardiovascular disease.
Source: NYT - July 17, 2014 Category: American Health Authors: By HARLAN M. KRUMHOLZ, M.D. Tags: Niacin National Institutes of Health Heart Cholesterol Body Stroke Krumholz, Harlan M medicine and health New England Journal of Medicine Statins (Cholesterol-Lowering Drugs) Featured Source Type: news

PodMed: A Medical News Roundup From Johns Hopkins (with audio)
(MedPage Today) -- This week's topics include stroke and risk, pill color and compliance, telecare for pain management, and niacin for prevention of heart disease.
Source: MedPage Today Cardiovascular - July 18, 2014 Category: Cardiology Source Type: news

Cardiovascular highlights from non-cardiology journals
Niacin fails to prevent cardiovascular events Observational studies have consistently demonstrated that levels of LDL cholesterol directly correlate with cardiovascular risk while HDL levels are inversely related to cardiovascular risk. Niacin is known to reduce LDL levels and concurrently raise HDL levels. In the HPS2-THRIVE study, 25,673 patients with a background of vascular disease were randomized to receive 2 g of extended-release niacin and 40 mg of laropiprant (an anti-flushing agent) or a matching placebo daily. Prior to starting the study, in a run-in phase, background statin therapy was standardized wit...
Source: Heart - September 23, 2014 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Looking into the Crystal Ball--Upcoming Drugs for Dyslipidemia
Dyslipidaemia is a critical risk factor for the development of cardiovascular complications such as ischemic heart disease and stroke. Although statins are effective anti-dyslipidemic drugs, their usage is fraught with issues such as failure of adequate lipid control in 30% of cases and intolerance in select patients. The limited potential of other alternatives such as fibrates, bile acid sequestrants and niacin has spurred the search for novel drug molecules with better efficacy and safety. CETP inhibitors such as evacetrapib and anacetrapib have shown promise in raising HDL besides LDL lowering property. Microsomal trigl...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 8, 2014 Category: Cardiology Authors: George, M., Selvarajan, S., Muthukumar, R., Elangovan, S. Tags: Review Articles Source Type: research

Edible mushrooms: improving human health and promoting quality life.
Authors: Valverde ME, Hernández-Pérez T, Paredes-López O Abstract Mushrooms have been consumed since earliest history; ancient Greeks believed that mushrooms provided strength for warriors in battle, and the Romans perceived them as the "Food of the Gods." For centuries, the Chinese culture has treasured mushrooms as a health food, an "elixir of life." They have been part of the human culture for thousands of years and have considerable interest in the most important civilizations in history because of their sensory characteristics; they have been recognized for their attractive culinary attributes. Nowadays, mu...
Source: International Journal of Microbiology - February 17, 2015 Category: Microbiology Tags: Int J Microbiol Source Type: research

Cholesterol: I Told You So!
Big Brother has finally come around to what I’ve been telling my patients for almost 30 years – stop worrying about cholesterol in your diet! The influential Dietary Guidelines Advisory Committee, the nation’s top nutrition panel, has now admitted they were WRONG about cholesterol. And they have now proclaimed this former dietary evil as no longer a “nutrient of concern.”1 They were slow – and, of course, wrong for decades – but at least they got there in the end. That means eggs are back on the menu for millions of Americans – yolk and all – although my patients have been enjoying their e...
Source: Al Sears, MD Natural Remedies - March 2, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Heart Health Nutrition cholesterol diet heart disease Source Type: news

Supplements That Save Lives And Bucks
I’m sure I don’t have to tell you about the high cost of medical care these days. The fact is that as costs continue to skyrocket, more and more Americans are driven into bankruptcy, because they cannot pay their medical bills. Too often, they even lose their homes. You may have even lost a neighbor to this disturbing trend. It may have even happened to you – although, I certainly hope not. That’s one reason I have always dedicated myself to keeping my patients out of hospitals – which often see patients as cash cows, instead of human beings. And a cornerstone of this philosophy has been based upon pr...
Source: Al Sears, MD Natural Remedies - June 3, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Nutrition supplements vitamins Source Type: news

Effects of Vascular and Nonvascular Adverse Events and of Extended-Release Niacin With Laropiprant on Health and Healthcare Costs Original Articles
Conclusions— In HPS2-THRIVE, the addition of extended-release niacin–laropiprant to statin-based therapy reduced quality of life–adjusted survival and increased hospital costs. Clinical Trial Registration— URL: http://clinicaltrials.gov. Unique identifier: NCT00461630.
Source: Circulation: Cardiovascular Quality and Outcomes - July 18, 2016 Category: Cardiology Authors: Kent, S., Haynes, R., Hopewell, J. C., Parish, S., Gray, A., Landray, M. J., Collins, R., Armitage, J., Mihaylova, B., on behalf of the HPS2-THRIVE Collaborative Group Tags: Cardiovascular Disease, Treatment, Cost-Effectiveness, Quality and Outcomes, Vascular Disease Original Articles Source Type: research

Estrogens and Coronary Artery Disease: New Clinical Perspectives.
Abstract In premenopausal women, endogenous estrogens are associated with reduced prevalence of arterial hypertension, coronary artery disease, myocardial infarction, and stroke. Clinical trials conducted in the 1990s such as HERS, WHI, and WISDOM have shown that postmenopausal treatment with horse hormone mixtures (so-called conjugated equine estrogens) and synthetic progestins adversely affects female cardiovascular health. Our understanding of rapid (nongenomic) and chronic (genomic) estrogen signaling has since advanced considerably, including identification of a new G protein-coupled estrogen receptor (GPER),...
Source: Advances in Pharmacology - July 29, 2016 Category: Drugs & Pharmacology Authors: Meyer MR, Barton M Tags: Adv Pharmacol Source Type: research

Nutrient intake and urinary incontinence in Korean women: A propensity score ‐matched analysis from the Korea National Health and Nutrition Examination Survey data
ConclusionHigh carbohydrate intake seems to be significantly related to female urinary incontinence in the Korean population.
Source: International Journal of Urology - August 28, 2017 Category: Urology & Nephrology Authors: Jun Ho Lee, Hyo Serk Lee Tags: Original Article Source Type: research

A Heart Risk Factor Even Doctors Know Little About
Up to one in five Americans have high levels of lipoprotein(a) in their blood, putting them at risk of heart attacks and strokes.
Source: NYT Health - January 9, 2018 Category: Consumer Health News Authors: ANAHAD O ’ CONNOR Tags: Tests (Medical) Heart Cholesterol Exercise Weight Stroke Lipoproteins Diet and Nutrition Drugs (Pharmaceuticals) Niacin Doctors Source Type: news

Lipoprotein(a) —It Is Risky, but What Do We Do About It?
AbstractPurpose of ReviewLipoprotein(a) [Lp(a)] is a pro-inflammatory, pro-thrombotic, and pro-atherogenic lipoprotein particle. Lp(a) binds and transports oxidized phospholipids in the bloodstream. It is one of the strongest genetic risk factors for coronary artery disease, stroke, and calcific aortic valve stenosis.Recent FindingsElevated Lp(a) levels, or hyperlipoproteinemia(a), is associated with cardiovascular outcomes even in high-risk individuals who achieve their low-density lipoprotein cholesterol target with statins. Lifestyle modification therapy and dietary supplements have little impact on plasma Lp(a) levels....
Source: Current Cardiovascular Risk Reports - September 29, 2018 Category: Cardiology Source Type: research