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Sex differences in atrial fibrillation and associated complications in hypertensive patients with left ventricular hypertrophy: The LIFE study
CONCLUSIONS: Among patients with hypertension and LVH, females with new-onset atrial fibrillation had a higher risk of stroke than males, especially in patients above 64 years. However, the risk did not differ between the sexes among patients with a history of atrial fibrillation.PMID:37382177 | DOI:10.1093/ajh/hpad057
Source: American Journal of Hypertension - June 29, 2023 Category: Cardiology Authors: Joshua B Feinberg Emil E Nielsen Sverre E Kjeldsen Richard B Devereux Eva Gerdts Kristian Wachtell Michael H Olsen Source Type: research

Electrocardiographic left atrial abnormalities and risk of incident stroke in hypertensive patients with electrocardiographic left ventricular hypertrophy
Conclusion: Abnormal PTFV1, a marker of left atrial abnormality, was strongly associated with incident stroke in hypertensive patients, independent of in-treatment SBP and other predictors of incident stroke. This association, in the absence of detectable atrial fibrillation, suggests that an underlying atrial cardiopathy may cause left atrial thrombus formation and a subsequent stroke without intervening clinically recognized atrial fibrillation.
Source: Journal of Hypertension - August 5, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research

Digoxin use and risk of mortality in hypertensive patients with atrial fibrillation
Conclusion: In hypertensive patients with ECG left ventricular hypertrophy with existing or new atrial fibrillation, digoxin use is not associated with a significantly increased risk of all-cause mortality after adjusting for other independent predictors of death and for the factors associated with the propensity to use digoxin in this population. These findings suggest that factors other than digoxin use may account for the increased mortality found with digoxin use in some studies. Clinical Trials Registration: http://clinicaltrials.gov/ct/show/NCT00338260?order=1
Source: Journal of Hypertension - June 5, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Relationship of Sudden Cardiac Death to New-Onset Atrial Fibrillation in Hypertensive Patients With Left Ventricular Hypertrophy Original Articles
Conclusions— Development of new-onset AF identifies hypertensive patients at increased risk of SCD. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00338260.
Source: Circulation: Arrhythmia and Electrophysiology - April 16, 2013 Category: Cardiology Authors: Okin, P. M., Bang, C. N., Wachtell, K., Hille, D. A., Kjeldsen, S. E., Dahlof, B., Devereux, R. B. Tags: Clinical Studies, Arrhythmias, clinical electrophysiology, drugs, Epidemiology Original Articles Source Type: research

Mitral Annular Calcification and Incident Ischemic Stroke in Treated Hypertensive Patients: The LIFE study.
ConclusionsMAC is common in treated hypertensive patients with ECG LVH and is an independent predictor of incident ischemic stroke. PMID: 23391619 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - February 7, 2013 Category: Cardiology Authors: De Marco M, Gerdts E, Casalnuovo G, Migliore T, Wachtell K, Boman K, Dahlöf B, Olsen MH, Kizer JR, Devereux RB, de Simone G Tags: Am J Hypertens Source Type: research