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Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation : A Multinational Population-Based Cohort Study
CONCLUSION: Among patients with AF, apixaban use was associated with lower risk for GIB and similar rates of ischemic stroke or systemic embolism, ICH, and all-cause mortality compared with dabigatran, edoxaban, and rivaroxaban. This finding was consistent for patients aged 80 years or older and those with chronic kidney disease, who are often underrepresented in clinical trials.PRIMARY FUNDING SOURCE: None.PMID:36315950 | DOI:10.7326/M22-0511
Source: Annals of Internal Medicine - October 31, 2022 Category: Internal Medicine Authors: Wallis C Y Lau Carmen Olga Torre Kenneth K C Man Henry Morgan Stewart Sarah Seager Mui Van Zandt Christian Reich Jing Li Jack Brewster Gregory Y H Lip Aroon D Hingorani Li Wei Ian C K Wong Source Type: research

Deadly Aneurysm-Linked Strokes Are Rising, Especially Among Black Americans
THURSDAY, Oct. 27, 2022 -- An often-deadly type of stroke -- subarachnoid hemorrhage -- is on the upswing in the United States, particularly among Black people, new research shows. Unlike the more common ischemic stroke, subarachnoid hemorrhage...
Source: Drugs.com - Daily MedNews - October 27, 2022 Category: General Medicine Source Type: news

Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage
Exp Neurol. 2022 Oct 21:114257. doi: 10.1016/j.expneurol.2022.114257. Online ahead of print.ABSTRACTGerminal matrix hemorrhage (GMH) is one of the leading causes of morbidity and mortality in preterm infants in the United States, with little progress made in its clinical management. Blood clots disrupting normal cerebrospinal fluid circulation and absorption after germinal matrix hemorrhage are key contributors towards post-hemorrhagic hydrocephalus development. n-formyl peptide receptor 2 (FPR2), a G-protein-coupled receptor, has been associated with the activation of p-ERK1/2, which in turn promotes the transcription of ...
Source: Experimental Neurology - October 24, 2022 Category: Neurology Authors: Jerry J Flores Yan Ding Prativa Sherchan John H Zhang Jiping Tang Source Type: research

Real-world outcomes associated with the use of the EmboTrap revascularization device for ischemic stroke in the United States
Conclusions This is the first study in the US to report real-world outcomes sourced by retrospective database analysis among patients with AIS undergoing MT using the EmboTrap device. Further research is needed to better understand performance of the EmboTrap device in real-world settings.
Source: Journal of NeuroInterventional Surgery - October 14, 2022 Category: Neurosurgery Authors: Brinjikji, W., Ikeme, S., Kottenmeier, E., Khaled, A., M, S., Khanna, R. Tags: Ischemic stroke Source Type: research

Endoluminal flow diverting stents for middle cerebral artery bifurcation aneurysms: multicenter cohort
Conclusion FDS treatment for MCA bifurcation aneurysms is feasible, with comparable safety and efficacy profiles to other available endovascular options when utilized in carefully selected aneurysms. Jailing of M2 branches was not associated with a higher risk of post-procedural ischemic complications.
Source: Journal of NeuroInterventional Surgery - October 14, 2022 Category: Neurosurgery Authors: Salem, M. M., Khorasanizadeh, M., Lay, S. V., Renieri, L., Kuhn, A. L., Sweid, A., Massari, F., Moore, J. M., Tjoumakaris, S. I., Jabbour, P., Puri, A. S., Ogilvy, C. S., Jankowitz, B. T., Burkhardt, J.-K., Kan, P., Limbucci, N., Cognard, C., Thomas, A. J Tags: Hemorrhagic stroke Source Type: research

Getting the guts to expand stroke treatment: The potential for microbiome targeted therapies
CONCLUSION: Recent research has illuminated the vital role of the GBA in propagating poor clinical outcomes, such as hemorrhagic transformation, following ischemic stroke. Considering this detrimental consequence of stroke, and the apparent role of the GBA role, future therapeutics should aim to mitigate this peripheral contribution to stroke complications.PMID:36217699 | DOI:10.1111/cns.13988
Source: CNS Neuroscience and Therapeutics - October 11, 2022 Category: Neuroscience Authors: Molly Monsour Davide M Croci Siviero Agazzi Cesario V Borlongan Source Type: research

North American multicenter experience with the Flow Redirection Endoluminal Device in the treatment of intracranial aneurysms
CONCLUSIONS: As the first large-scale North American multicenter FRED experience, this study confirmed the ease of successful FRED deployment but suggested lower efficacy and a higher rate of complications than reported by previous European and South American studies on FRED and other flow-diverting devices. The authors recommend judicious use of this device until future studies can better elucidate the long-term outcomes of FRED treatment.PMID:36087324 | DOI:10.3171/2022.7.JNS221371
Source: Journal of Neurosurgery - September 10, 2022 Category: Neurosurgery Authors: MirHojjat Khorasanizadeh Max Shutran Clemens M Schirmer Mohamed M Salem Andrew J Ringer Ramesh Grandhi Alim P Mitha Michael R Levitt Brian T Jankowitz Philipp Taussky Ajith J Thomas Justin M Moore Christopher S Ogilvy Source Type: research

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