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Supporting stroke survivors to meet their personal rehabilitation needs in community-based arm rehabilitation: development of initial programme theories to explore what may work for whom, how and under what circumstances
ConclusionThis realist-informed study enabled the development of initial programme theories to explain how and in what circumstances the augmented arm rehabilitation intervention may have enabled participants to meet their personal rehabilitation needs. Encouraging participants’ sense of intrinsic motivation and building therapeutic relationships appeared instrumental. These initial programme theories require further testing, refinement, and integration with the wider literature.
Source: Frontiers in Neurology - June 2, 2023 Category: Neurology Source Type: research

Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic review, and meta-analysis
Publication date: Available online 7 August 2019Source: The Lancet NeurologyAuthor(s): Susanna M Zuurbier, Charlotte R Hickman, Christos S Tolias, Leon A Rinkel, Rebecca Leyrer, Kelly D Flemming, David Bervini, Giuseppe Lanzino, Robert J Wityk, Hans-Martin Schneble, Ulrich Sure, Rustam Al-Shahi Salman, Scottish Audit of Intracranial Vascular Malformations Steering CommitteeSummaryBackgroundAntithrombotic (anticoagulant or antiplatelet) therapy is withheld from some patients with cerebral cavernous malformations, because of uncertainty around the safety of these drugs in such patients. We aimed to establish whether antithro...
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research

The Clinical Course of Dural Arteriovenous Fistulae: A 10-Year Population-Based Cohort Study of Dural Arteriovenous Fistulae in Scotland (P1.116)
Conclusions: Venous anatomy is associated with dAVF initial presentation of stroke. Adverse events during untreated follow-up are rare, treatment is occasionally ‘curative’, and adverse events after treatment are infrequent.Disclosure: Dr. Ghandour has nothing to disclose. Dr. Kobayashi has nothing to disclose. Dr. Al-Shahi Salman has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ghandour, D., Kobayashi, A., Al-Shahi Salman, R. Tags: Neuroepidemiology: Cerebrovascular Disease Source Type: research

Polygenic risk of ischemic stroke is associated with cognitive ability
Conclusions: The findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability.
Source: Neurology - February 15, 2016 Category: Neurology Authors: Harris, S. E., Malik, R., Marioni, R., Campbell, A., Seshadri, S., Worrall, B. B., Sudlow, C. L. M., Hayward, C., Bastin, M. E., Starr, J. M., Porteous, D. J., Wardlaw, J. M., Deary, I. J., On behalf of the METASTROKE Consortium Tags: All Cerebrovascular disease/Stroke, Intelligence, Cognitive aging, Cohort studies, All Genetics ARTICLE Source Type: research

Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial
Publication date: Available online 27 March 2015 Source:The Lancet Neurology Background Brain scans are essential to exclude haemorrhage in patients with suspected acute ischaemic stroke before treatment with alteplase. However, patients with early ischaemic signs could be at increased risk of haemorrhage after alteplase treatment, and little information is available about whether pre-existing structural signs, which are common in older patients, affect response to alteplase. We aimed to investigate the association between imaging signs on brain CT and outcomes after alteplase. Methods IST-3 was a multicentre, randomised ...
Source: The Lancet Neurology - March 27, 2015 Category: Neurology Source Type: research

Implementing a Simple Care Bundle Is Associated With Improved Outcomes in a National Cohort of Patients With Ischemic Stroke Clinical Sciences
Conclusions— Achieving a care bundle for ischemic stroke is associated with reduced mortality at 30 days and 6 months and increased likelihood of discharge to usual residence at 6 months.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Turner, M., Barber, M., Dodds, H., Murphy, D., Dennis, M., Langhorne, P., Macleod, M.-J., on behalf of the Scottish Stroke Care Audit Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Complications following incident stroke resulting in readmissions: an analysis of data from three Scottish health surveys
ConclusionsCardiovascular events and infections are the most frequent poststroke complications resulting in readmissions. The time period until event provides a possibility to focus monitoring on those people at risk of readmission and introduce preventative measures, thereby reducing readmission‐associated costs.
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Dmitry Ponomarev, Claire Miller, Lindsay Govan, Caroline Haig, Olivia Wu, Peter Langhorne Tags: Research Source Type: research