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The Effect of Allograft Transplantation of Sertoli Cell on Expression of NF- кB, Bax Proteins, ...
In this study, a remarkable decrease in neurological deficits, infection, blood-brain barrier permeability, and brain edema was observed in the cell transplant recipient group in comparison with the ischemia group. Probably, a reduction in inflammation (NF-кB factor) an d apoptosis (Bax) following injection of Sertoli cells result in amelioration of ischemic damages induced by MCAO surgery.
Source: Iranian Journal of Pharmaceutical Research - June 8, 2020 Category: Drugs & Pharmacology Source Type: research

The effect of Allograft Transplantation of Sertoli Cell on Expression of NF- кB, Bax Proteins, ...
In this study, a remarkable decrease in neurological deficits, infection, blood-brain barrier permeability, and brain edema was observed in the cell transplant recipient group in comparison with the ischemia group. Probably, a reduction in inflammation (NF-кB factor) an d apoptosis (Bax) following injection of Sertoli cells result in amelioration of ischemic damages induced by MCAO surgery.
Source: Iranian Journal of Pharmaceutical Research - May 27, 2020 Category: Drugs & Pharmacology Source Type: research

The Potential Effect of Intravenous Calcitriol on the Ischemia-Reperfusion Injury and ...
Conclusion: Administration of calcitriol in patients with non-ST-segment elevation acute coronary syndromes undergoing elective PCI can attenuate the increase in serum inflammatory biomarkers in the serum (hs-CRP and hs-IL-6) and thus decrease the inflammatory reaction caused by PCI.
Source: Iranian Journal of Pharmaceutical Research - February 28, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of neuroprtective effects of L-Carnitine and Fat emulsion in the CVA patients: a ...
Stroke was the second most frequent cause of death after coronary artery disease. The purpose of this study was to evaluate the effects of L-carnitine and Intralipid Fat emulsion alone and in combination in patients with ischemic stroke. In a prospective, RCT, and double-blind study 100 patients with MCA ischemic cerebrovascular accident who were admitted in the first 24 hours of injury entered the study. Patients were randomly assigned into four groups of L-carnitine, Fat emulsion, L-carnitine plus Fat emulsion and control. 500 ml of Fat emulsion 10% was infused over 6 to 12 hours and 1 gr of l-carnitine was given orally ...
Source: Iranian Journal of Pharmaceutical Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

The Potential Effect of Intravenous Calcitriol on the Ischemia-Reperfusion Injury and ...
Conclusion: Administration of calcitriol in patients with non-ST-segment elevation acute coronary syndromes undergoing elective PCI can attenuate the increase in serum inflammatory biomarkers in the serum (hs-CRP and hs-IL-6) and thus decrease the inflammatory reaction caused by PCI.
Source: Iranian Journal of Pharmaceutical Research - November 30, 2019 Category: Drugs & Pharmacology Source Type: research

Tenecteplase versus reteplase in acute myocardial infarction: A network meta-analysis of ...
Conclusions: Indirect comparison suggests similar efficacy and safety of tenecteplase and reteplase. Hence, the use of each one of the two medicines depends on price, facility, and accessibility of the medicine.
Source: Iranian Journal of Pharmaceutical Research - June 30, 2019 Category: Drugs & Pharmacology Source Type: research

The streptokinase therapy complications and its associated risk factors in patients with acute ...
Acute myocardial infarction (AMI) is one of the main leading causes of mortality and morbidity. Despite the progress in the treatment of AMI, streptokinase is still being used in many countries. Because of the critical condition of patients with AMI and complications of streptokinase therapy, this study was performed to evaluate the pattern of adverse drug reaction (ADRs) induced by streptokinase and its associated risk factors in patients with acute ST elevation MI. A prospective cross-sectional study in a 14-month period was done at the university affiliated referral cardiovascular center. The Naranjo probability scale a...
Source: Iranian Journal of Pharmaceutical Research - February 28, 2018 Category: Drugs & Pharmacology Source Type: research