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Blood phytosterols in relation to cardiovascular diseases and mediating effects of blood lipids and hematological traits: a Mendelian randomization analysis
CONCLUSION: The study suggests that genetic predisposition to higher blood total sitosterol is linked to a greater risk of major CVDs. Moreover, blood nonHDL-C and apolipoprotein B might mediate a significant proportion of the associations between sitosterol and coronary diseases.PMID:37270173 | DOI:10.1016/j.metabol.2023.155611
Source: Atherosclerosis - June 3, 2023 Category: Cardiology Authors: Yimin Zhao Zhenhuang Zhuang Yueying Li Wendi Xiao Zimin Song Ninghao Huang Wenxiu Wang Xue Dong Jinzhu Jia Tao Huang Source Type: research

Replacing PT-INR Monitoring of Warfarin with Fiix-NR in Clinical Practice Reduces Thromboembolism without Increasing Bleeding Despite Reduced Number of Dose Adjustments
Conclusions: These results are in agreement with the results of the Fiix-trial and show that ignoring factor VII during VKA monitoring is safe and leads to reduction in thromboembolism without increasing bleeding. Although TTR was identical in both groups, the dose adjustment need was reduced possibly indicating that less anticoagulation variability in the Fiix-NR group explains reduced thromboembolism.FigureDisclosuresGudmundsdottir: Hart Biologicals Ltd: Consultancy, Patents & Royalties: Hart Biologicals Ltd is commercializing the Fiix-PT which will be ready for marketing in Europe in the beginning of year 2019 and p...
Source: Blood - November 21, 2018 Category: Hematology Authors: Oskarsdottir, A. R., Gudmundsdottir, B. R., Onundarson, P. T. Tags: 332. Antithrombotic Therapy: Poster I Source Type: research

Incidence of First Stroke: A Population Study in Iceland Brief Reports
Conclusions— Incidence of first stroke in Iceland is similar to other Western countries. The high number of paroxysmal atrial fibrillation found during the 24-hour ECG suggests that atrial fibrillation may be underdiagnosed in patients with stroke.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Hilmarsson, A., Kjartansson, O., Olafsson, E. Tags: Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Epidemiology Brief Reports Source Type: research