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Total 19 results found since Jan 2013.
For Humanitarian Workers, Mental Health Needs Are Often Overlooked
July 19, 2017It ' s time to take mental well-being during complex emergencies seriously.In my family there was always a strong culture of suffering in silence. We were encouraged as children to ignore small injuries and illnesses, and to soldier on without complaint.I only realized the full extent of this embedded behavior when my elderly mother dislocated her shoulder and refused to go to the hospital for 24 hours, somehow believing that it would get better on its own.It has always been difficult to shake off this deeply ingrained sense that to ask for help is somehow weak. When, in a one year period, my son had a serious...
Source: IntraHealth International - July 19, 2017 Category: International Medicine & Public Health Authors: mnathe Source Type: news
Citicoline retards myopia progression following form deprivation in guinea pigs
The retinal dopaminergic system is involved in the myopic shift following form deprivation. Citicoline has been demonstrated to stimulate the dopaminergic system in the brain and retina. Furthermore, citicoline has been used in many neurogenic diseases, such as senile cognitive impairment, stroke and Parkinson's disease as well as in amblyopia and glaucoma. Our aim was to investigate the effect of citicoline on the refractive state and retinal dopamine level in form deprivation myopia of guinea pigs. Guinea pigs, at an age of four weeks, were randomly divided into normal control, deprivation, deprived + citicoline and depr...
Source: Experimental Biology and Medicine - May 31, 2016 Category: Research Authors: Mao, J., Liu, S., Fu, C. Tags: Pharmacology/Toxicology Source Type: research
Test of the Usefulness of a Paradigm to Identify Potential Cardiovascular Liabilities of Four Test Articles With Varying Pharmacological Properties in Anesthetized Guinea Pigs
This study aimed to establish the feasibility of an anesthetized guinea pig preparation to assess functional liabilities in the setting of simultaneous drug-induced electrocardiographic/hemodynamic changes, by evaluating the effects of various compounds with known cardiovascular properties on direct and indirect indices of left ventricular function. In short, twenty nine male guinea pigs were instrumented to measure electrocardiograms, systemic arterial pressure, and left ventricular pressure-volume relationships. After baseline measurement, all animals were given intravenous infusions of vehicle and two escalating concent...
Source: Toxicological Sciences - January 31, 2014 Category: Toxicology Authors: Kijtawornrat, A., Ueyama, Y., del Rio, C., Sawangkoon, S., Buranakarl, C., Chaiyabutr, N., Hamlin, R. L. Tags: Research Article Source Type: research
Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs
Thrombolytic therapy is the cornerstone of treatment of acute atherothrombotic ischemic stroke but is associated with brain hemorrhage; antiplatelet therapy has limited efficacy and is still associated with intracranial bleeding. Therefore, new antithrombotic approaches with a better efficacy/safety ratio are required. We have assessed the effect of ALX-0081, a Nanobody against the A1 domain of von Willebrand factor (VWF) that blocks VWF binding to GPIb, of the thrombolytic agent recombinant tissue plasminogen activator (rtPA), and of the GPIIb/IIIa antagonist tirofiban, in a middle cerebral artery (MCA) thrombosis model i...
Source: Blood - June 20, 2013 Category: Hematology Authors: Momi, S., Tantucci, M., Van Roy, M., Ulrichts, H., Ricci, G., Gresele, P. Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research
