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Geographic and temporal variation in the treatment and outcomes of atrial fibrillation: a population-based analysis of national quality indicators
The objective of this study was to assess for potential geographic variation in the quality of atrial fibrillation care in Alberta, Canada.METHODS: In a population-based cohort of adults (age ≥ 18 yr) with incident nonvalvular atrial fibrillation (NVAF) diagnosed between Apr. 1, 2008, and Mar. 31, 2016, in Alberta, we investigated the variation in national quality indicators of atrial fibrillation care developed by the Canadian Cardiovascular Society. Specifically, we assessed the geographic and temporal variation in the proportion of patients with initiation of oral anticoagulant therapy, persistence with therapy, ische...
Source: cmaj - August 2, 2022 Category: General Medicine Authors: Derek S Chew Flora Au Yuan Xu Braden J Manns Marcello Tonelli Stephen B Wilton Brenda Hemmelgarn Shiying Kong Derek V Exner Amity E Quinn Source Type: research

Clinical characteristics, multiorgan dysfunction and outcomes of patients with COVID-19: a prospective case series
This study provides further evidence that COVID-19 is a multisystem disease involving neurologic, cardiac and thrombotic dysfunction, without evidence of hepatic dysfunction. Patients have persistent organ dysfunction after hospital discharge, underscoring the need for research on long-term outcomes of COVID-19 survivors.PMID:35853662 | DOI:10.9778/cmajo.20210151
Source: cmaj - July 19, 2022 Category: General Medicine Authors: Kimia Honarmand Kyle Fiorini Debarati Chakraborty Daniel Gillett Karishma Desai Claudio Martin Karen J Bosma Marat Slessarev Ian M Ball Tina Mele Danielle LeBlanc Sameer Elsayed Alejandro Lazo-Langner Mike J Nicholson Robert Arntfield John Basmaji Source Type: research

Intravascular lithotripsy-assisted PCI for severely calcified coronary lesions: evaluating the impact on quality of life and outcomes
ConclusionsCoronary IVL is a safe and effective adjunctive therapy for treating heavily calcified coronary lesions. This cohort shows high procedural success and a significant reduction in CCS angina at follow-up.
Source: Irish Journal of Medical Science - July 9, 2022 Category: General Medicine Source Type: research

Changes in ischemic stroke presentations, management and outcomes during the first year of the COVID-19 pandemic in Alberta: a population study
CMAJ. 2022 Mar 28;194(12):E444-E455. doi: 10.1503/cmaj.211003.ABSTRACTBACKGROUND: Pandemics may promote hospital avoidance, and added precautions may exacerbate treatment delays for medical emergencies such as stroke. We sought to evaluate ischemic stroke presentations, management and outcomes during the first year of the COVID-19 pandemic.METHODS: We conducted a population-based study, using linked administrative and stroke registry data from Alberta to identify all patients presenting with stroke before the pandemic (Jan. 1, 2016 to Feb. 27, 2020) and in 5 periods over the first pandemic year (Feb. 28, 2020 to Mar. 31, 2...
Source: Canadian Medical Association Journal - March 29, 2022 Category: General Medicine Authors: Aravind Ganesh Jillian M Stang Finlay A McAlister Oleksandr Shlakhter Jessalyn K Holodinsky Balraj Mann Michael D Hill Eric E Smith Source Type: research

Bedtime versus morning use of antihypertensives for cardiovascular risk reduction (BedMed): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial
Introduction Sleep-time blood pressure correlates more strongly with adverse cardiovascular events than does daytime blood pressure. The BedMed trial evaluates whether bedtime antihypertensive administration, as compared with conventional morning use, reduces major adverse cardiovascular events. Methods and analysis Design Prospective randomised, open-label, blinded end-point trial. Participants Hypertensive primary care patients using blood pressure lowering medication and free from glaucoma. Setting Community primary care providers in 5 Canadian provinces (British Columbia, Alberta, Saskatchewan, Manitoba and Ontario) a...
Source: BMJ Open - February 24, 2022 Category: General Medicine Authors: Garrison, S. R., Kolber, M. R., Allan, G. M., Bakal, J., Green, L., Singer, A., Trueman, D. R., McAlister, F. A., Padwal, R. S., Hill, M. D., Manns, B., McGrail, K., O'Neill, B., Greiver, M., Froentjes, L. S., Manca, D. P., Mangin, D., Wong, S. T., MacLea Tags: Open access, Cardiovascular medicine Source Type: research

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