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The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke.
This study aimed to determine the correlation between serine hydroxymethyl transferase 1 (SHMT1) gene methylation and ischemic stroke. A total of 202 age- and sex-matched individuals were included. Quantitative methylation-specific polymerase chain reaction (qMSP-PCR) was used to analyze the DNA methylation level. The plasma homocysteine (Hcy) concentration was much higher in ischemic cases than in controls (p = 0.009), while the HDL levels in stroke cases were considerably lower than in controls (p = 0.005). A significantly higher level of SHMT1 methylation was observed in the ischemic strokes (58.82 ± 17.83 %) compared ...
Source: Bosnian Journal of Basic Medical Sciences - December 3, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

SARS-CoV-2 infection of the nervous system: A review of the literature on neurological involvement in novel coronavirus disease (COVID-19).
In conclusion, SARS-CoV-2 infection can cause multiple neurological syndromes in a more complex presentation. Therefore, this review elucidated the involvement of the nervous system in SARS-CoV-2 infection and will hopefully help improve the management of COVID-19. PMID: 32530389 [PubMed - as supplied by publisher]
Source: Bosnian Journal of Basic Medical Sciences - June 13, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

High MTHFR promoter methylation levels in men confer protection against ischemic stroke.
In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the analysis of potential interactions between environmental factors and DNA methylation levels that affect IS risk. We recruited 164 patients with hypertension and IS (case group) and 345 age- and sex-matched patients with hypertension only (control group). Demographic and clinical information was obtained using questionnaires, and blood samples were collected for biochemical analyses. Fluorescence quantitative methylation-specific PCR (qMSP) was used to detect MTHFR promoter methyl...
Source: Bosnian Journal of Basic Medical Sciences - May 4, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

DNA methylation of AHCY may increase the risk of ischemic stroke.
This study aimed to determine the correlation between DNA methylation of the gene encoding S-adenosylhomocysteine hydrolase (AHCY) and the risk of ischemic stroke in 64 ischemic stroke patients and 138 patients with traumatic brain injury (control group). The methylation level of AHCY was analyzed using quantitative methylation-specific polymerase chain reaction. Statistically significant differences in AHCY methylation levels were observed between the case group [medians (interquartile range): 0.13% (0.09%, 0.27%)] and the control group [0.06% (0.00%, 0.17%), p < 0.0001], and these associations remained significant in ...
Source: Bosnian Journal of Basic Medical Sciences - February 7, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): Hmwe Hmwe Kyu, Degu Abate, Kalkidan Hassen Abate, Solomon M Abay, Cristiana Abbafati, Nooshin Abbasi, Hedayat Abbastabar, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Molla Abebe, Zegeye Abebe, Olifan Zewdie Abil, Victor Aboyans, Aklilu Roba Abrham, Laith Jamal Abu-Raddad, Niveen M E Abu-Rmeileh, Manfred Mario Kokou AccrombessiSummaryBackgroundHow long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading caus...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Non-endoscopic minimally invasive evacuation of intracerebral haematoma (ICH): A case report.
Authors: Velnar T Abstract Spontaneous intracerebral haemorrhage (ICH) is one of the most serious causes of stroke, leading to high rates of disability and mortality. In addition to intensive medical treatment, surgery may help to improve the prognosis in patients with ICH. A rapid reversal of coagulopathy is essential in these patients, although it may be difficult to achieve in various bleeding disorders. In such cases, when surgery is needed, a minimally invasive approach is recommended. In this case report, we described and shortly discussed the evacuation of ICH with a minimally invasive non-endoscopic surgica...
Source: Bosnian Journal of Basic Medical Sciences - October 26, 2017 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

Safety of once- or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: A NOAC-TR study.
In this study, we investigated the adherence to once- or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September 2015 and 28 February 2016, included 2214 patients receiving NOACs for at least 3 months, due to NVAF. Patients receiving once-daily or twice-daily NOAC doses were 1:1 propensity score matched for baseline demographic characteristics and the presence of other diseases. The medication adherence was assessed by the 8-item Morisky Medication Adherence Scale. Risk factors were investigated in relatio...
Source: Bosnian Journal of Basic Medical Sciences - October 3, 2017 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

DL-2-amino-3-phosphonopropionic acid protects primary neurons from oxygen-glucose deprivation induced injury.
This study was aimed to explore the role of DL-AP3 in primary neuronal cell cultures. Primary neurons were divided into four groups: (1) a control group that was not treated; (2) DL-AP3 group treated with 10 μM of DL-AP3; (3) OGD group, in which neurons were cultured under OGD conditions; and (4) OGD + DL-AP3 group, in which OGD model was first established and then the cells were treated with 10 μM of DL-AP3. Neuronal viability and apoptosis were measured using Cell Counting Kit-8 and flow cytometry. Expressions of phospho-Akt1 (p-Akt1) and cytochrome c were detected using Western blot. The results showed that DL-AP3...
Source: Bosnian Journal of Basic Medical Sciences - December 16, 2016 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research

Progress on diabetic cerebrovascular diseases.
Authors: Zhou H, Zhang X, Lu J Abstract Diabetic cerebrovascular diseases are defined as cerebral vascular diseases induced by diabetes with sugar, fat and a series of nutrient substance metabolic disorders, resulting in intracranial large and small vessel diseases. About 20%-40% patients with type 2 diabetes suffer from cerebral blood vessel diseases. Diabetic cerebrovascular diseases are the main causes of death in patients with diabetes mellitus. The major clinical manifestations are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel disease and acute cerebral vascular disease. The pathogenesis...
Source: Bosnian Journal of Basic Medical Sciences - December 20, 2015 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research

Elevation in circulating YKL-40 concentration in patients with cerebrovascular disease.
Authors: Xu X, Ma H, Xu J, Huang H, Wu X, Xiong Y, Zhan H, Huang F Abstract YKL-40 is a novel inflammatory protein. Elevated serum levels of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases, but the circulating profile of YKL-40 in patients with cerebrovascular disease has been less investigated. This prospective observational study aimed to determine serum levels of YKL-40 in patients with different subtypes and severities of cerebrovascular disease. Eighty patients with acute ischemic stroke, 30 patients with acute hemorrhagic stroke, 15 patients with transient ischemic...
Source: Bosnian Journal of Basic Medical Sciences - December 20, 2015 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research

De novo mutation in the NOTCH3 gene causing CADASIL.
We report a new case of patient with de novo mutation of the NOTCH3 gene and a condition strongly suggestive of CADASIL (migraine, stroke, and white matter abnormalities), except that this patient did not have any first-degree relatives with similar symptoms. PMID: 24579972 [PubMed - indexed for MEDLINE]
Source: Bosnian Journal of Basic Medical Sciences - December 20, 2015 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research