• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Heritability of R2* iron in the basal ganglia and cortex
CONCLUSIONS: Regional brain iron concentrations are mainly driven by genetic factors while environmental factors contribute to a certain extent. Brain iron levels in the basal ganglia and cortex are controlled by distinct sets of genes.PMID:35951362 | DOI:10.18632/aging.204212
Source: Aging - August 11, 2022 Category: Biomedical Science Authors: Edith Hofer Lukas Pirpamer Christian Langkammer Christian Tinauer Sudha Seshadri Helena Schmidt Reinhold Schmidt Source Type: research

Kidney function, brain morphology and cognition in the elderly: sex differences in the Austrian Stroke Prevention Study
Aging (Albany NY). 2022 Jan 13;14(undefined). doi: 10.18632/aging.203829. Online ahead of print.ABSTRACTImpaired kidney function is associated with structural brain changes and cognitive dysfunction. In the aging kidney, hemodynamic and structural alterations reduce the glomerular filtration rate (eGFR). Little is known about differences between men and women regarding decline of kidney function and brain damage. In this community-based study, we assessed associations between the eGFR, focal and diffuse brain abnormalities and cognitive functions. Sex-specific effects were analyzed by interaction terms eGFR x sex on brain ...
Source: Aging - January 13, 2022 Category: Biomedical Science Authors: Michael Kolland Edith Hofer Lukas Pirpamer Daniela Eibl Christian Enzinger Alexander R Rosenkranz Reinhold Schmidt Source Type: research

Factors influencing serum neurofilament light chain levels in normal aging
CONCLUSIONS: Age is the most important factor influencing sNfL concentrations, getting increasingly relevant in elderly people. BMI further influences sNfL levels, especially at younger age, whereas renal function gets increasingly relevant in the elderly.PMID:34923481 | DOI:10.18632/aging.203790
Source: Aging - December 19, 2021 Category: Biomedical Science Authors: Marisa Koini Lukas Pirpamer Edith Hofer Arabella Buchmann Daniela Pinter Stefan Ropele Christian Enzinger Pascal Benkert David Leppert Jens Kuhle Reinhold Schmidt Michael Khalil Source Type: research

Association of vitamin D metabolites with cognitive function and brain atrophy in elderly individuals - the Austrian stroke prevention study
CONCLUSIONS: Vitamin D deficient individuals appear to have a modest reduction of memory function without structural brain atrophy. Future studies should explore if vitamin D supplementation can improve cognitive function.PMID:33825696 | DOI:10.18632/aging.202930
Source: Aging - April 7, 2021 Category: Biomedical Science Authors: Sieglinde Zelzer Edith Hofer Andreas Meinitzer Eva Fritz-Petrin Sebastian Simstich Walter Goessler Reinhold Schmidt Markus Herrmann Source Type: research

The Evaluation of the Effectiveness of Austrians Disease Management Program in Patients with Type 2 Diabetes Mellitus - A Population-Based Retrospective Cohort Study
by Regina Riedl, Martin Robausch, Andrea Berghold AimTo evaluate the effectiveness of the Austrian Disease Management Program (DMP) ‘Therapie aktiv—Diabetes im Griff’ for patients with type 2 diabetes mellitus concerning patient-relevant outcomes (mortality, myocardial infarction and stroke) and costs. MethodsBased on routine health insurance data, we conducted a population-based retrospective cohort study using a propensity score (PS) matched control group design. The DMP-group consists of participants enrolled in the program during 2008 and 2009 (n = 7181). Out of 208.532 patients with no participation in the DMP u...
Source: PLoS One - August 16, 2016 Category: Biomedical Science Authors: Regina Riedl Source Type: research