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Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients.
Abstract The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collected and used for hematological analyses, fetal hemoglobin quantification, and genotyping of 3.7 kb alpha-thalassemia deletion by GAP-PCR. The frequency of the 3.7 kb alpha-thalassemia deletion in homozygosity was 12.5% and in heterozygosity was 55.0%. An increase in alpha-thalassemia frequency ...
Source: Molecular Biology Reports - July 5, 2020 Category: Molecular Biology Authors: Santos B, Delgadinho M, Ferreira J, Germano I, Miranda A, Arez AP, Faustino P, Brito M Tags: Mol Biol Rep Source Type: research

Realizing Effectiveness Across Continents with Hydroxyurea: Enrollment and Baseline Characteristics of the Multicenter REACH Study in sub ‐Saharan Africa
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - January 10, 2018 Category: Hematology Authors: Patrick T. McGann, Thomas N. Williams, Peter Olupot ‐Olupot, George A. Tomlinson, Adam Lane, José Luís Reis da Fonseca, Robert Kitenge, George Mochamah, Ham Wabwire, Susan Stuber, Thad A. Howard, Kathryn McElhinney, Banu Aygun, Teresa Latham, Brígida Tags: Research Article Source Type: research

Angola:Angola With More Than 11.000 New Cases of Stroke
[ANGOP] Luanda -At least 11.490 new cases of cerebral vascular accidents have been recorded to date countrywide, said on Tuesday in Luanda the Secretary of State for Public Health, Manuel Dias da Cunha.
Source: AllAfrica News: Health and Medicine - November 1, 2017 Category: African Health Source Type: news