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Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling
CONCLUSIONS: These findings provide novel molecular insight into HS-induced structural changes in eGC and EC composition that may increase cardiovascular risk and potentially guide the development of new diagnostics and therapeutic interventions.PMID:36700429 | DOI:10.1161/ATVBAHA.122.318439
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 26, 2023 Category: Cardiology Authors: Arada Vinaiphat Kalailingam Pazhanchamy Gnanasekaran JebaMercy SoFong Cam Ngan Melvin Khee-Shing Leow Hee Hwa Ho Yong-Gui Gao Kah Leong Lim A Mark Richards Dominique P V de Kleijn Christopher P Chen Raj N Kalaria Jian Liu Deborah D O'Leary Neil E McCarthy Source Type: research

Sodium Handling and Interaction in Numerous Organs.
Abstract Salt (NaCl) is a prerequisite for life. Excessive intake of salt, however, is said to increase disease risk including hypertension, arteriosclerosis, heart failure, renal disease, stroke, and cancer. Therefore, considerable research has been expended on the mechanism of sodium handling based on the current concepts of sodium balance. The studies have necessarily relied on relatively short-term experiments and focused on extremes of salt intake in humans. Ultra-long-term salt balance has received far less attention. We performed long-term salt balance studies at intakes of 6, 9, and 12 g/day and found that...
Source: American Journal of Hypertension - March 20, 2020 Category: Cardiology Authors: Minegishi S, Luft FC, Titze J, Kitada K Tags: Am J Hypertens Source Type: research