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Diverse roles of mitochondria in ischemic stroke
Publication date: June 2018 Source:Redox Biology, Volume 16 Author(s): Jenq-Lin Yang, Sujira Mukda, Shang-Der Chen Stroke is the leading cause of adult disability and mortality in most developing and developed countries. The current best practices for patients with acute ischemic stroke include intravenous tissue plasminogen activator and endovascular thrombectomy for large-vessel occlusion to improve clinical outcomes. However, only a limited portion of patients receive thrombolytic therapy or endovascular treatment because the therapeutic time window after ischemic stroke is narrow. To address the current shortage of st...
Source: Redox Biology - March 15, 2018 Category: Biology Source Type: research

Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke Research
For ischemic stroke treatment, extension of the therapeutic time window (TTW) of thrombolytic therapy with tissue plasminogen activator (tPA) and amelioration of secondary ischemia/reperfusion (I/R) injury are most desirable. Our previous studies have indicated that liposomal delivery of neuroprotectants into an ischemic region is effective for stroke treatment. In the present study, for solving the above problems in the clinical setting, the usefulness of combination therapy with tPA and liposomal fasudil (fasudil-Lip) was investigated in ischemic stroke model rats with photochemically induced thrombosis, with clots that ...
Source: FASEB Journal - May 1, 2017 Category: Biology Authors: Fukuta, T., Asai, T., Yanagida, Y., Namba, M., Koide, H., Shimizu, K., Oku, N. Tags: Research Source Type: research