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Specialty: Biomedical Science
Condition: Thrombosis

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Total 134 results found since Jan 2013.

Research Articles Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke
Neuroprotection for acute ischemic stroke is achievable with the eicosapeptide nerinetide, an inhibitor of the protein-protein interactions of the synaptic scaffolding protein PSD-95. However, nerinetide is subject to proteolytic cleavage if administered after alteplase, a standard-of-care thrombolytic agent that nullifies nerinetide’s beneficial effects. Here, we showed, on the basis of pharmacokinetic data consistent between rats, primates, and humans, that in a rat model of embolic middle cerebral artery occlusion (eMCAO), nerinetide maintained its effectiveness when administered before alteplase. Because of its s...
Source: Science Translational Medicine - April 7, 2021 Category: Biomedical Science Authors: Mayor-Nunez, D., Ji, Z., Sun, X., Teves, L., Garman, J. D., Tymianski, M. Tags: Research Articles Source Type: research

Decreased clot burden is associated with factor XIII Val34Leu polymorphism and better functional outcomes in acute ischemic stroke patients treated with intravenous thrombolysis
ConclusionsCBS was found to be a significant independent predictor of thrombolysis outcomes. FXIII-A Leu34 carrier status was associated with smaller thrombus burden, which is consistent with thein vitro described whole blood clot mass reducing effects of the allele, but the polymorphism had no effect on thrombolysis outcomes.
Source: PLoS One - July 7, 2021 Category: Biomedical Science Authors: Istv án Szegedi Source Type: research

Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke
ConclusionsWe found that serum levels of CCL-23, CXCL-12, IGFBP-6, IL-5, LYVE-1, PAI-1, PDGF-AA, ST-2, and TNF- α at admission were associated with post-thrombolytic ENI in stroke. The role of biomarkers warrants further investigation. Trial registrationClinical Trial Registration: https://www.clinicaltrials.gov; identifier: NCT02854592.
Source: PLoS One - October 31, 2022 Category: Biomedical Science Authors: Yu Cui Source Type: research

Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease
In conclusion, both in acute and chronic cerebrovascular disease patients, ADAMTS13 levels were significantly decreased, with the lowest ADAMTS13 levels found in acute str oke patients. This difference was even more distinct when the ratio of VWF:ADAMTS13 was considered. These results demonstrate the potentially important involvement of the VWF/ADAMTS13 axis in ischemic stroke.
Source: PLoS One - June 7, 2017 Category: Biomedical Science Authors: Frederik Denorme Source Type: research

Computational research of mTORC1 inhibitor on cerebral ischemia-reperfusion injury
Aging (Albany NY). 2021 Aug 3;13(undefined). doi: 10.18632/aging.203371. Online ahead of print.ABSTRACTIschemic stroke contributes to more than 80% of all strokes and has the four characteristics of high prevalence, high disability, high mortality, and high recurrence. Stroke is a preventable and controllable disease. In addition to controlling the primary disease, effective prevention and control measures need to be given to the occurrence and development of stroke. With the development and progress of modern treatment methods for ischemic stroke, the mortality and disability rate have decreased significantly. At present,...
Source: Aging - August 3, 2021 Category: Biomedical Science Authors: Hui Li Wenzhuo Yang Zhenhua Wang Xu Wang Yulei Hao Jianxin Xi Han Lu Zhishan Du Jiachun Feng Bao Zhang Di Ma Source Type: research

Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice
Conclusion Although secreted platelet 5-HT does not appear to play a crucial role in the development of reperfusion injury after stroke, it is essential to amplify the second phase of platelet activation through SOCE and plays an important role in thrombus stabilization.
Source: PLoS One - January 22, 2016 Category: Biomedical Science Authors: Karen Wolf et al. Source Type: research

Demonstration of proof-of-concept of < i > StrokeShield < /i > system for complete closure and occlusion of the left atrial appendage for non-valvular atrial fibrillation therapy
by Mark S. Slaughter, Gretel Monreal, Steven C. Koenig, Guruprasad A. Giridharan, Landon H. Tompkins, Jorge H. Jimenez In the US, the most significant morbidity and mortality associated with non-valvular atrial fibrillation (NVAF) is embolic stroke, with 90% of thrombus originating from the left atrial appendage (LAA). Anticoagulation is the preferred treatment for the prevention of stroke in NVAF patients, but cl inical studies have demonstrated high levels of non-compliance and increased risk of bleeding or ineligibility for anticoagulation therapy, especially in the elderly population where the incidence of NVAF is hig...
Source: PLoS One - June 22, 2021 Category: Biomedical Science Authors: Mark S. Slaughter Source Type: research

Prevalence of Atrial Fibrillation and Antithrombotic Therapy in Hemodialysis Patients: Cross-Sectional Results of the Vienna InVestigation of AtriaL Fibrillation and Thromboembolism in Patients on HemoDIalysis (VIVALDI)
ConclusionsThe prevalence of AF is high amongst HD patients and is associated with age, sex, and distinct comorbidities. Practice patterns of antithrombotic treatment indicate a lack of consensus for stroke prevention in HD patients with AF.
Source: PLoS One - January 3, 2017 Category: Biomedical Science Authors: Oliver K önigsbrügge Source Type: research

Therapeutic efficacy of direct oral anticoagulants and vitamin K antagonists for left ventricular thrombus: Systematic review and meta-analysis
ConclusionsEfficacy and adverse outcomes of therapy with DOACs and VKAs do not differ. Randomized controlled trials are needed to determine the optimal anticoagulant strategy.
Source: PLoS One - July 26, 2021 Category: Biomedical Science Authors: Tetsuji Kitano Source Type: research

Analysis of mechanical parameters on the thromboembolism using a patient-specific computational model.
Abstract Ischemic stroke is a major cause of death and long-term disabilities worldwide. In this paper, we aim to represent a comprehensive simulation of the motion of emboli through cerebrovascular network within patient-specific computational model. The model consists of major arteries of the circle of Willis reconstructed from magnetic resonance angiography images, pulsatile flow and emboli with different sizes and material properties. Here, the fluid-structure interactions method was used to simulate the motion of deformable and rigid emboli through cerebral arteries. Hemodynamic changes in the circle of Willi...
Source: Biomechanics and Modeling in Mechanobiology - January 25, 2016 Category: Biomedical Science Authors: Khodaee F, Vahidi B, Fatouraee N Tags: Biomech Model Mechanobiol Source Type: research

Quality of Anticoagulation and Treatment Satisfaction in Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonist: Result from the KORean Atrial Fibrillation Investigation II.
Conclusion: INR was poorly controlled in Korean NVAF patients treated with VKA. VKA users also showed low treatment satisfaction. PMID: 30505257 [PubMed - in process]
Source: Journal of Korean Medical Science - December 8, 2018 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Effectiveness and safety of rivaroxaban versus warfarin in Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation: A real-world nationwide cohort study
ConclusionsIn Taiwanese patients with end-stage renal disease and nonvalvular atrial fibrillation, rivaroxaban may be associated with a similar risk of major bleeding but a lower risk of thromboembolism compared with warfarin. The potential benefit of 10 mg of rivaroxaban in this population requires further investigation.
Source: PLoS One - April 8, 2021 Category: Biomedical Science Authors: Yi-Cheng Lin Source Type: research

Long-term Outcomes of Clopidogrel Monotherapy versus Prolonged Dual Antiplatelet Therapy beyond 12 Months after Percutaneous Coronary Intervention in High-risk Patients
CONCLUSION: Compared with prolonged DAPT, clopidogrel monotherapy showed similar long-term outcomes in patients at high-risk after second-generation DES implantation.PMID:33904262 | DOI:10.3346/jkms.2021.36.e106
Source: Journal of Korean Medical Science - April 27, 2021 Category: Biomedical Science Authors: Dong Yeon Kim Sung Woo Cho Kyu Tae Park Jong Hwa Ahn Taek Kyu Park Yong Ho Jang Ki Hong Choi Joo Myung Lee Jeong Hoon Yang Young Bin Song Jin Ho Choi Seung Hyuk Choi Hyeon Cheol Gwon Sang Hoon Lee Joo Yong Hahn Source Type: research