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Direct Oral Anticoagulants in Patients on Chronic Dialysis and Concomitant Atrial Fibrillation: A Common Clinical Impasse
Front Biosci (Schol Ed). 2022 Jul 21;14(3):21. doi: 10.31083/j.fbs1403021.ABSTRACTThe most frequent arrhythmia treated is atrial fibrillation (AF), which necessitates the use of oral anticoagulants (OACs) to reduce the risk of thromboembolism and stroke. Patients with chronic kidney disease are more likely to develop AF, with a 10% frequency among those on chronic dialysis. Warfarin is the most widely prescribed OAC for individuals with end-stage kidney disease (ESKD). On the other hand, direct OACs (DOACs) are generally safer than warfarin, with fewer fatal bleeding events and a fixed dose that does not require close inte...
Source: Frontiers in Bioscience - Scholar - September 22, 2022 Category: Biomedical Science Authors: Nikolaos Ktenopoulos Marios Sagris Panagiotis Theofilis Sophia Lionaki Loukianos S Rallidis Source Type: research

A high sucrose diet modifies brain oxylipins in a sex-dependent manner
Oxylipins are oxidation products of polyunsaturated fatty acids (PUFAs), produced through the action of cyclooxygenase (COX), lipoxygenase (LOX), cytochrome p450 (CYP), and non-enzymatic oxidation pathways [1]. Oxylipins can be esterified or free, with free oxylipins presumed to be the biologically active form [1]. Although the study of oxylipins and their functions is relatively new, there is evidence of their involvement in thrombosis, inflammation, the development of diabetes, the progression of cardiovascular diseases, and stroke [2 –7].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - October 7, 2022 Category: Biomedical Science Authors: Jennifer E. Norman, Saivageethi Nuthikattu, Dragan Milenkovic, John C. Rutledge, Amparo C. Villablanca Tags: Original research article Source Type: research

Direct Oral Anticoagulants in Patients on Chronic Dialysis and Concomitant Atrial Fibrillation: A Common Clinical Impasse
Front Biosci (Schol Ed). 2022 Jul 21;14(3):21. doi: 10.31083/j.fbs1403021.ABSTRACTThe most frequent arrhythmia treated is atrial fibrillation (AF), which necessitates the use of oral anticoagulants (OACs) to reduce the risk of thromboembolism and stroke. Patients with chronic kidney disease are more likely to develop AF, with a 10% frequency among those on chronic dialysis. Warfarin is the most widely prescribed OAC for individuals with end-stage kidney disease (ESKD). On the other hand, direct OACs (DOACs) are generally safer than warfarin, with fewer fatal bleeding events and a fixed dose that does not require close inte...
Source: Frontiers in Bioscience - Scholar - September 22, 2022 Category: Biomedical Science Authors: Nikolaos Ktenopoulos Marios Sagris Panagiotis Theofilis Sophia Lionaki Loukianos S Rallidis Source Type: research

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