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Computational research of mTORC1 inhibitor on cerebral ischemia-reperfusion injury
Aging (Albany NY). 2021 Aug 3;13(undefined). doi: 10.18632/aging.203371. Online ahead of print.ABSTRACTIschemic stroke contributes to more than 80% of all strokes and has the four characteristics of high prevalence, high disability, high mortality, and high recurrence. Stroke is a preventable and controllable disease. In addition to controlling the primary disease, effective prevention and control measures need to be given to the occurrence and development of stroke. With the development and progress of modern treatment methods for ischemic stroke, the mortality and disability rate have decreased significantly. At present,...
Source: Aging - August 3, 2021 Category: Biomedical Science Authors: Hui Li Wenzhuo Yang Zhenhua Wang Xu Wang Yulei Hao Jianxin Xi Han Lu Zhishan Du Jiachun Feng Bao Zhang Di Ma Source Type: research

Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients
In conclusion, poor metabolizers of CYP2C19 and TT groups of P2Y12 G52T may be significant predictors of poor clinical outcomes in elderly patients.PMID:33707344 | DOI:10.18632/aging.202799
Source: Aging - March 12, 2021 Category: Biomedical Science Authors: Jung-Joon Cha Jae Hyoung Park Hyung Joon Joo Soon Jun Hong Tae Hoon Ahn Byeong-Keuk Kim WonYong Shin Sung Gyun Ahn JungHan Yoon Yong Hoon Kim Yun-Hyeong Cho Woong Chol Kang Weon Kim Young-Hyo Lim Hyeon Cheol Gwon Woong Gil Choi Do-Sun Lim Source Type: research

A novel risk model to predict first-ever ischemic stroke in heart failure with reduced ejection fraction.
Abstract Patients with heart failure are at increased risk for ischemic stroke. We aim to develop a more accurate stroke risk prediction tools identify high-risk patients with heart failure with reduced ejection fraction (HFrEF). Patient data were extracted retrospectively from the electronic medical database between January 2009 and February 2019. Univariate and multivariate Cox regression analysis were performed to identify independent predictors, which were utilized to construct a nomogram for predicting ischemic stroke. AUROC analysis was used to compare the prognostic value between the new risk score and CHAD...
Source: Aging - February 1, 2021 Category: Biomedical Science Authors: Zhou X, Yu L, Hu W, Shi R, Ji Y, Zhou C, Xue C, Yu G, Huang W, Shan P Tags: Aging (Albany NY) Source Type: research

Efficacy and safety of an antithrombotic regimen for atrial fibrillation patients with acute coronary syndrome or those undergoing percutaneous coronary intervention: a meta-analysis.
This study evaluated the benefit of dual therapy in reducing ischemic events in atrial fibrillation (AF) patients presenting with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). We searched PubMed, Cochrane Library, and ClinicalTrials.gov for randomized controlled trials (RCTs) comparing dual and triple therapies (oral anticoagulation plus aspirin and P2Y12 inhibitor) for AF patients with ACS or those undergoing PCI. The composite primary outcome included all-cause death, myocardial infarction (MI), stent thrombosis (ST), or stroke. Relative risk (RR) and the corresponding 95% confiden...
Source: Aging - June 30, 2020 Category: Biomedical Science Authors: Guo W, Chen X, Hao Y, Liu Q, Peng C, Zhao L, Feng Z, Wang X, Ruan H, Li L Tags: Aging (Albany NY) Source Type: research

Association of DIAPH1 gene polymorphisms with ischemic stroke.
Abstract DIAPH1 is a formin protein involved in actin polymerization with important roles in vascular remodeling and thrombosis. To investigate potential associations of DIAPH1 single-nucleotide polymorphisms (SNPs) with hypertension and stroke, 2,012 patients with hypertension and 2,210 controls, 2,966 stroke cases [2,212 ischemic stroke (IS), 754 hemorrhagic stroke (HS)] and 2,590 controls were enrolled respectively in the case-control study. A total of 4,098 individual were included in the cohort study. DIAPH1 mRNA expression was compared between 66 IS [43 small artery occlusion (SAO) and 23 large-artery athero...
Source: Aging - January 2, 2020 Category: Biomedical Science Authors: Ren Z, Chen X, Tang W, Li J, Yang S, Chen Y, Zhao X, Zong H, Liu C, Shen C Tags: Aging (Albany NY) Source Type: research

Independent ischemic stroke risk factors in older Americans: a systematic review.
Abstract The Framingham Stroke Risk Profile (FSRP) is a validated model for predicting 10-year ischemic stroke risk in middle-aged adults, yet has not been demonstrated to consistently translate in older populations. This is a systematic review of independent risk factors measured among > 65 year olds, with subsequent first ischemic stroke, using PRISMA guidelines. We appraised peer-reviewed publications that included participants > 65 years old at risk assessment. Combined with other criteria, results were abstracted from 28 papers reporting six types of stroke risk factors: Serologic/Diagnostic, Convention...
Source: Aging - May 23, 2019 Category: Biomedical Science Authors: Singer J, Gustafson D, Cummings C, Egelko A, Mlabasati J, Conigliaro A, Levine SR Tags: Aging (Albany NY) Source Type: research