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Anticoagulation for Venous Thromboembolism: Impact on the Risk of Major Adverse Cardiovascular Events
Chest. 2022 Jun 14:S0012-3692(22)01087-X. doi: 10.1016/j.chest.2022.05.038. Online ahead of print.ABSTRACTBACKGROUND: It was recently established that patients who developed venous thromboembolism (VTE) are at increased risk of major adverse cardiovascular events (MACE) than the general population. However, whether the anticoagulation used for VTE influences the risk of MACE remains undescribed.RESEARCH QUESTION: Does the anticoagulant treatment for VTE impact the risk of subsequent MACE?STUDY DESIGN AND METHODS: We included patients from a large prospective cohort, who received only one family of anticoagulant treatment a...
Source: Chest - June 17, 2022 Category: Respiratory Medicine Authors: Steve Raoul Noumegni Raphael Le Mao Claire de Moreuil Cl ément Hoffmann Emmanuelle Le Moigne C écile Tromeur Vincent Mansourati Bahaa Nasr Md Jean-Christophe Gentric Marie Guegan Elise Poulhazan Luc Bressollette Karine Lacut Romain Didier Francis Coutur Source Type: research

Comparing the Effectiveness and Safety of Non-Vitamin K Antagonist Oral Anticoagulants and Warfarin in the Elderly Asian Patients with Atrial Fibrillation: A Nationwide Cohort Study.
CONCLUSIONS: Compared to warfarin, NOACs were associated with a significantly lower risk of adverse events, with heterogeneity in treatment effects among different age strata. Overall, the clear safety signal in favor of NOACs over warfarin was evident irrespective of age strata, being most marked in the most elderly. PMID: 31809694 [PubMed - as supplied by publisher]
Source: Chest - December 2, 2019 Category: Respiratory Medicine Authors: Chao TF, Chiang CE, Liao JN, Chen TJ, Lip GYH, Chen SA Tags: Chest Source Type: research

Direct acting oral anticoagulants (DOACs) in critically ill patients.
Abstract The direct acting oral anticoagulants (DOACs) have been increasingly utilized over vitamin K antagonists (VKA) in recent years because they do not require monitoring and have an immediate anti-coagulation effect. In general, DOACs have shown a better safety profile and non-inferiority for venous thromboembolism (VTE) prophylaxis and treatment, and stroke prevention in patients with atrial fibrillation, when compared to VKA agents in the non-ICU population. Whether this holds true in patients who are critically ill remains unknown. In this review, we will address the role of DOACs in special ICU population...
Source: Chest - June 24, 2019 Category: Respiratory Medicine Authors: Rali P, Gangemi A, Moores A, Mohrien K, Moores L Tags: Chest Source Type: research

Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report.
CONCLUSIONS: Oral anticoagulation is the optimal choice of antithrombotic therapy for patients with AF with ≥1 non-gender CHA2DS2VASc stroke risk factor(s). PMID: 30144419 [PubMed - as supplied by publisher]
Source: Chest - August 21, 2018 Category: Respiratory Medicine Authors: Lip GYH, Banerjee A, Boriani G, Chiang CE, Fargo R, Freedman B, Lane DA, Ruff CT, Turakhia M, Werring D, Patel S, Moores L Tags: Chest Source Type: research

Reversal of Direct Oral Anticoagulants: Current Status and Future Directions
Semin Respir Crit Care Med 2017; 38: 040-050 DOI: 10.1055/s-0036-1597831Direct oral anticoagulants (DOACs) are increasingly used for prevention and treatment of venous thromboembolism and for prevention of stroke in patients with nonvalvular atrial fibrillation. In phase III clinical trials that included more than 100,000 patients, the DOACs were at least as effective as vitamin K antagonists (VKAs) and were associated with less serious bleeding, particularly less intracranial bleeding. Real-world evidence supports these outcomes. Despite this, some physicians and patients are concerned about serious bleeding or emergencie...
Source: Seminars in Respiratory and Critical Care Medicine - February 15, 2017 Category: Respiratory Medicine Authors: Weitz, Jeffrey I. Tags: Review Article Source Type: research

New anticoagulants for the treatment of venous thromboembolism
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in p...
Source: Jornal Brasileiro de Pneumologia - May 6, 2016 Category: Respiratory Medicine Source Type: research

Bronchial thermoplasty in a patient with difficult-to-control asthma
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in p...
Source: Jornal Brasileiro de Pneumologia - May 6, 2016 Category: Respiratory Medicine Source Type: research

HRCT in smoking-related interstitial lung diseases: a kaleidoscopic overlap of patterns
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in p...
Source: Jornal Brasileiro de Pneumologia - May 6, 2016 Category: Respiratory Medicine Source Type: research

Pre-operative evaluation in obstructive sleep apnea patients undergoing bariatric surgery: sleep laboratory limitations
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in p...
Source: Jornal Brasileiro de Pneumologia - May 6, 2016 Category: Respiratory Medicine Source Type: research

Open letter to city, state, and federal health authorities, to State Health Councils, and to the National Council of Municipal Health Secretaries in Brazil
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in p...
Source: Jornal Brasileiro de Pneumologia - May 6, 2016 Category: Respiratory Medicine Source Type: research

Interlobular septal thickening
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in p...
Source: Jornal Brasileiro de Pneumologia - May 6, 2016 Category: Respiratory Medicine Source Type: research

What is the importance of calculating sample size?
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in p...
Source: Jornal Brasileiro de Pneumologia - May 6, 2016 Category: Respiratory Medicine Source Type: research

Stroke/thromboembolism and intracranial hemorrhage in a 'real world' atrial fibrillation population: The CAFBO STUDY (Complications of Atrial Fibrillation in the BOlogna area).
CONCLUSION IEs occurred mainly in elderly patients who received ASA or no treatment. Half of anticoagulated patients with IEs had subtherapeutic INRs. Therapeutic approaches to elderly subjects with AF require an effective anticoagulant treatment strategy. PMID: 24810397 [PubMed - as supplied by publisher]
Source: Chest - May 8, 2014 Category: Respiratory Medicine Authors: Palareti G, Salomone L, Cavazza M, Guidi M, Muscari A, Boriani G, Di Micoli A, Guizzardi G, Procaccianti G, Guidetti A, Binetti N, Malservisi S, Masina M, Viola A, Bua V, Ongari M, Diaspri G, Lip GY Tags: Chest Source Type: research

Relationship of the SAME-TT2R2score to poor quality anticoagulation, stroke, clinically relevant bleeding and mortality in patients with atrial fibrillation.
CONCLUSION We demonstrate that the SAME-TT2R2 score was predictive for an increasing risk of stroke/TE, severe bleeding, major BARC bleeding and death, reflecting poor anticoagulation control (and labile INRs) on VKA amongst our patients with AF. PMID: 24722973 [PubMed - as supplied by publisher]
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Lip GY, Haguenoer K, Saint-Etienne C, Fauchier L Tags: Chest Source Type: research

The impact of smoking on thromboembolism and mortality in patients with incident atrial fibrillation: insights from the Danish Diet, Cancer and Health study.
CONCLUSIONS Smoking is associated with a higher risk of thromboembolism or death in patients with AF even after adjusting for well-recognised risk factors used in stroke risk stratification schemes. The associations may be modified by sex, as the associations were strongest among women. PMID: 24091709 [PubMed - as supplied by publisher]
Source: Chest - October 3, 2013 Category: Respiratory Medicine Authors: Albertsen IE, Rasmussen LH, Lane DA, Overvad TF, Skjøth F, Overvad K, Lip GY, Larsen TB Tags: Chest Source Type: research

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