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Stroke and cancer
Rev Neurol (Paris). 2023 Apr 4:S0035-3787(23)00891-3. doi: 10.1016/j.neurol.2023.03.009. Online ahead of print.ABSTRACTAssociation between stroke and cancer is well-established and has led to a growing literature over the past decades. Risk of ischemic and hemorrhagic stroke is increased among patients with newly diagnosed cancer and 5-10% of stroke patients bear an active cancer. All cancers are concerned, but hematological malignancy in childhood and adenocarcinoma from lung, digestive tract and pancreas in adults are most usually identified. Unique stroke mechanisms are dominated by hypercoagulation, a condition that ma...
Source: Revue Neurologique - April 6, 2023 Category: Neurology Authors: M Zuber Source Type: research

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research

Recurrent brain ischaemia and deep vein thrombosis: the clot thickens.
We describe the assessment of this presentation and discuss the causes and management of cancer-related stroke. PMID: 28578318 [PubMed - as supplied by publisher]
Source: Practical Neurology - June 3, 2017 Category: Neurology Authors: Turner D, Scully M, Stone S, Werring DJ Tags: Pract Neurol Source Type: research

Risk of recurrent thromboembolic phenomena after ischemic stroke in patients with malignancy
In the 1860s, Trousseau first described the association between cancer and a hypercoagulable state.1 Ironically, he later diagnosed himself with phlebitis and predicted his own death from pancreatic cancer. Secretion of procoagulants by tumor cells, vascular damage secondary to immune response, and iatrogenic injury from chemotherapeutic agents, radiotherapy, and in-dwelling catheters, among other mechanisms, may contribute to hypercoagulability in the setting of cancer.2 This places oncology patients at high risk of cerebrovascular phenomena, which frequently leads to patients' initial diagnosis.3 Despite this well-define...
Source: Neurology - June 30, 2014 Category: Neurology Authors: Starke, R. M. Tags: EDITORIALS Source Type: research