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Specialty: Cytology
Condition: Thrombosis
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Total 46 results found since Jan 2013.
Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
CONCLUSIONS: SARS-CoV-2 can lead to neurological complications, such as cerebrovascular manifestations, motor movement complications, and cognitive decline. COVID-19 infection can result in cerebrovascular symptoms and diseases, such as strokes and thrombosis. The virus can affect the neural system, disrupt cognitive function and cause neurological disorders. To combat the epidemic, it is crucial to repurpose drugs currently in use quickly and develop novel therapeutics.PMID:37649125 | PMC:PMC10469568 | DOI:10.1186/s40001-023-01293-2
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Kritika Tyagi Prachi Rai Anuj Gautam Harjeet Kaur Sumeet Kapoor Ashish Suttee Pradeep Kumar Jaiswal Akanksha Sharma Gurpal Singh Ravi Pratap Barnwal Source Type: research
Cardiovascular risk in vasculitis
Best Pract Res Clin Rheumatol. 2023 Jun 9:101831. doi: 10.1016/j.berh.2023.101831. Online ahead of print.ABSTRACTThe present review summarizes the burden, risk factors, biomarkers of and therapeutic consideration for cardiovascular disease in systemic vasculitis. Ischemic heart disease (IHD) and stroke are intrinsic features of Kawasaki disease, Takayasu arteritis, Giant Cell Arteritis (GCA), and Behcet's disease. The risk of IHD and stroke is increased in anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and cryoglobulinemic vasculitis. Behcet's disease could present with venous thromboembolism. The risk of...
Source: Cell Research - June 11, 2023 Category: Cytology Authors: Durga Prasanna Misra Aman Sharma George A Karpouzas George D Kitas Source Type: research
A Critical Role for ERO1 α in Arterial Thrombosis and Ischemic Stroke
CONCLUSIONS: Our results suggest that ERO1α acts as a thiol oxidase for Ca2+ signaling molecules, STIM1 and SERCA2, and enhances cytosolic Ca2+ levels, promoting platelet activation and aggregation. Our study provides evidence that ERO1α may be a potential target to reduce thrombotic events.PMID:37132383 | DOI:10.1161/CIRCRESAHA.122.322473
Source: Cell Research - May 3, 2023 Category: Cytology Authors: Vishwanath Jha Bei Xiong Tripti Kumari Gavriel Brown Jinzhi Wang Kyungho Kim Jingu Lee Nathan Asquith John Gallagher Lillian Asherman Taylor Lambert Yanyan Bai Xiaoping Du Jeong-Ki Min Rajan Sah Ali Javaheri Babak Razani Jin-Moo Lee Joseph E Italiano Jaeh Source Type: research
Cumulative Incidence of Thromboembolism and Prognostic Impact of Stroke in < em > BRAF < /em > V600E-mutant Non-small-cell Lung Cancer
CONCLUSION: A substantial proportion of patients with BRAF V600E-mutant lung cancer experienced thromboembolism during their disease course. CRS of undetermined source may predict a worse prognosis in this population.PMID:36697098 | DOI:10.21873/anticanres.16237
Source: Cell Research - January 25, 2023 Category: Cytology Authors: Sho Yamada Akimasa Sekine Eri Hagiwara Yoko Onodera Erina Tabata Satoshi Ikeda Hideya Kitamura Tomohisa Baba Shigeru Komatsu Takashi Ogura Source Type: research
Monogenic Causes in Familial Stroke Across Intracerebral Hemorrhage and Ischemic Stroke Subtypes Identified by Whole-Exome Sequencing
Cell Mol Neurobiol. 2022 Dec 29. doi: 10.1007/s10571-022-01315-3. Online ahead of print.ABSTRACTWhole exome sequencing (WES) has been used to detect rare causative variants in neurological diseases. However, the efficacy of WES in genetic diagnosis of clinically heterogeneous familial stroke remains inconclusive. We prospectively searched for disease-causing variants in unrelated probands with defined familial stroke by candidate gene/hotspot screening and/or WES, depending on stroke subtypes and neuroimaging features at a referral center. The clinical significance of each variant was determined according to the American C...
Source: Cellular and Molecular Neurobiology - December 29, 2022 Category: Cytology Authors: Li-Hsin Chang Nai-Fang Chi Chun-Yu Chen Yung-Shuan Lin Shao-Lun Hsu Jui-Yao Tsai Hui-Chi Huang Chun-Jen Lin Chih-Ping Chung Chien-Yi Tung Chung-Jiuan Jeng Yi-Chung Lee Yo-Tsen Liu I-Hui Lee Source Type: research
A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo
In conclusion, DhHP-3 has bioactivity of CIRI inhibition through suppression of the ROS-induced apoptosis.PMID:36442518 | DOI:10.1016/j.yexcr.2022.113432
Source: Experimental Cell Research - November 28, 2022 Category: Cytology Authors: Fanwei Meng Junfeng Ke Jinze Li Changhui Zhao Jiaqing Yan Liping Wang Source Type: research
Platelets, Macrophages, and Thromboinflammation in Chagas Disease
J Inflamm Res. 2022 Oct 4;15:5689-5706. doi: 10.2147/JIR.S380896. eCollection 2022.ABSTRACTChagas disease (CD) is a major health problem in the Americas and an emerging health problem in Europe and other nonendemic countries. Several studies have documented persistence of the protozoan parasite Trypanosoma cruzi, and oxidative and inflammatory stress are major pathogenic factor. Mural and cardiac thrombi, cardiac arrhythmias, and cardiomyopathy are major clinical features of CD. During T. cruzi infection, parasite-released factors induce endothelial dysfunction along with platelet (PLT) and immune-cell activation. PLTs hav...
Source: Cell Research - October 11, 2022 Category: Cytology Authors: Subhadip Choudhuri Nisha J Garg Source Type: research
Age and composition of the thrombus retrieved by mechanical thrombectomy from patients with acute ischemic stroke are associated with revascularization and clinical outcomes
CONCLUSION: Thrombus composition correlated with revascularization and clinical outcomes. The composition of an acute ischemic thrombus may reflect the pathophysiology of stroke and influence treatment efficacy.PMID:36126564 | DOI:10.1016/j.thromres.2022.09.004
Source: Cell Research - September 20, 2022 Category: Cytology Authors: Hisao Shimizu Kinta Hatakeyama Kozue Saito Ryogo Shobatake Nobuyuki Takahashi Jun Deguchi Hidemori Tokunaga Keiji Shimada Ichiro Nakagawa Kaoru Myochin Kazuya Sakai Masayuki Kubo Atsushi Yamashita Chiho Obayashi Kazuma Sugie Masanori Matsumoto Source Type: research
