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Lipid Droplet Protein PLIN1 Regulates Inflammatory Polarity in Human Macrophages and is Involved in Atherosclerotic Plaque Development by Promoting Stable Lipid Storage
CONCLUSION: There was a relationship between macrophage polarity, cytosolic LD size, and PLIN1/PLIN2 expression levels. PLIN2 was mainly expressed in arterial plaques in symptomatic stroke patients, and associated with the inflammatory phenotype of human macrophages, while PLIN1 expression is closely associated with plaque stability and the anti-inflammatory phenotype.PMID:35662076 | DOI:10.5551/jat.63153
Source: Journal of Atherosclerosis and Thrombosis - June 6, 2022 Category: Cardiology Authors: Kyu Yong Cho Hideaki Miyoshi Akinobu Nakamura Andrew S Greenberg Tatsuya Atsumi Source Type: research

Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
CONCLUSIONS: Plaque echogenicity correlated with enrichment of distinct molecular pathways and identified BCLAF1, previously not described in atherosclerosis, as the most significant gene. Functionally, BCLAF1 seems necessary for survival and transdifferentiation of SMCs into a macrophage-like phenotype. The role of BCLAF1 in plaque vulnerability should be further evaluated.PMID:35321563 | DOI:10.1161/ATVBAHA.121.317018
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 24, 2022 Category: Cardiology Authors: Urszula Rykaczewska Quanyi Zhao Peter Saliba-Gustafsson Mariette Lengquist Malin Kronqvist Otto Bergman Zhiqiang Huang Kent Lund Katarina Waden Vila Z Pons Kenneth Caidahl Josefin Skogsberg Vladana Vukojevic Jan H N Lindeman Joy Roy G öran K Hansson Ecka Source Type: research

Immediate postoperative interventional therapy for neurologic salvage when cerebral thromboembolism complicates carotid endarterectomy
In this study,we report three patients in our institution who received immediate post-operative interventional therapy for neurological salvage, in the setting of cerebral embolism after CEA.PMID:34957793 | DOI:10.31083/j.rcm2204158
Source: Reviews in Cardiovascular Medicine - December 27, 2021 Category: Cardiology Authors: Chunlei Wang Bingjie Zheng Ilgiz Gareev Ozal Beylerli Yan Gu Shancai Xu Zhiyong Ji Pei Wu Huaizhang Shi Source Type: research

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