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248 * long-term circulatory support with rotary blood pumps: is it worthwhile?
Conclusions: Patients on long-term support have an excellent haemodynamic profile and show an acceptable risk-benefit ratio. Although heart transplantation remains the ultimate target at present, our data show that long-term circulatory support is a viable option with the potential to become a more permanent solution in the long-term.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Capoccia, M., Sabashnikov, A., Mohite, P. N., Garcia Saez, D., Zych, B., Hards, R., Bowles, C. T., Moza, A., De Robertis, F., Bahrami, T., Amrani, M., Banner, N. R., Simon, A. R. Tags: Left ventricular assist devices II: Long-term support Source Type: research

Thromboembolism in a patient with a mechanical mitral valve during anticoagulation with dabigatran etexilate.
We report a 57-year-old man with a mechanical heart valve who experienced acute upper limb thromboembolism during dabigatran intake. Dabigatran might be inadequate for thromboprophylaxis after mechanical valve replacement. PMID: 24182477 [PubMed - in process]
Source: The Annals of Thoracic Surgery - November 1, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kuwauchi S, Watanabe S, Abe K, Yamasaki M, Ito J, Kawazoe K Tags: Ann Thorac Surg Source Type: research

Ten-year screening for thrombocytopenia after aortic valve replacement
CONCLUSIONS Thrombocytopenia and Elisa (+) are more common after AVR than after other procedures, and both were associated with increased adverse clinical outcomes. Age and lower preoperative platelet count were associated with postoperative thrombocytopenia and Elisa (+).
Source: Interactive CardioVascular and Thoracic Surgery - April 21, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Sun, X., Hill, P. C., Ellis, J., Corso, P. J., Taylor-Panek, S. L., Chen, F. Tags: Adult Cardiac Source Type: research

Mechanical heart valve prosthesis and warfarin – Treatment quality and prognosis
Conclusion: Patients with a lower warfarin treatment quality measured by TTR have a higher risk of complications such as severe bleeding or death. A TTR of 83% or higher at the individual level should be obtained for best outcome.
Source: Thrombosis Research - March 18, 2014 Category: Hematology Authors: Bartosz Grzymala-Lubanski, Ashkan Labaf, Erling Englund, Peter J. Svensson, Anders Själander Tags: Clinical Studies Source Type: research

The effects of a low international normalized ratio on thromboembolic and bleeding complications in patients with mechanical mitral valve replacement
Conclusions: This study showed that a target INRs of 2.0-2.5 are acceptable for preventing TEs and safe in terms of bleeding complications in patients with mechanical MVR.
Source: Journal of Cardiothoracic Surgery - May 7, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Ugur BalAlp AydinalpKerem YilmazEmre OzcalikSenem HasirciIlyas AtarBahadir GultekinAtilla SezginHaldun Muderrisoglu Source Type: research

Efficacy and safety of early parenteral anticoagulation as a bridge to warfarin after mechanical valve replacement.
In conclusion, we found that early after mechanical valve replacement, therapeutic dose bridging was associated with a similar risk of thromboembolic complications, but a 2.5 to 3-fold increased risk of major bleeding compared with prophylactic dose bridging. PMID: 25183209 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - August 28, 2014 Category: Hematology Authors: Mathew JG, Spyropoulos AC, Yusuf A, Vincent J, Eikelboom J, Shestakovska O, Fremes S, Noora J, Guo L, Peterson M, Pai M, Whitlock R Tags: Thromb Haemost Source Type: research

Dental implants in patients at high risk for infective endocarditis: a preliminary study
Abstract: The safety of dental implant placement in patients at high risk for infective endocarditis (IE) has never been shown. The outcome of osseointegrated implants in patients with artificial heart valves or with a history of an infected valve is not known. In this article we describe our experience of dental implant placement in patients at high risk for IE. A retrospective study was conducted on patients at high risk for IE who underwent dental implant placement. All the patients received prophylactic antibiotic treatment before the surgical procedure, in accordance with the relevant American Heart Association guidel...
Source: International Journal of Oral and Maxillofacial Surgery - June 2, 2014 Category: ENT & OMF Authors: M. Findler, T. Chackartchi, E. Regev Tags: Oral Medicine Source Type: research

013 * european multicentre experience with sutureless perceval valve: clinical and haemodynamic outcomes up to 5 years in over 700 patients
Conclusion: This European multicentre experience with the largest cohort of patients with sutureless valves to date shows excellent clinical and haemodynamic results that remain stable even up to 5 years follow-up. Even in this elderly patient cohort with 40% octogenarians, both early and late mortality were very low. There were no valve migrations, structural valve degeneration or valve thrombosis in follow-up. The sutureless technique is a promising alternative to biological AVR.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Shrestha, M., Laborde, F., Carrel, T., Fischlein, T., Meuris, B., Madonna, F., Misfeld, M., Haverich, A. Tags: Small incisions and sutureless valves: A perfect marriage Source Type: research

164 * decision-making in aortic root surgery in marfan syndrome: bleeding, thromboembolism and risk of reintervention after valve-sparing or mechanical aortic root replacement
Conclusion: The calculated annual failure rate after VSRR using the reimplantation technique was lower than the annual risk for thromboembolic or bleeding events. As the perioperative risk of reinterventions after VSRR itself is low, patients might benefit from VSRR even if they have to undergo redo surgery during follow-up.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Schoenhoff, F., Langhammer, B., Reineke, D., Kadner, A., Carrel, T. Tags: Proximal thoracic aortic pathology: Variations on a theme Source Type: research

Anti-streptokinase antibodies and outcome of fibrinolytic therapy with streptokinase for left-sided prosthetic valve thrombosis
Conclusion Anti-SK antibody titres are not associated with success of fibrinolytic therapy using SK in patients with left-sided PVT.
Source: American Heart Journal - October 31, 2014 Category: Cardiology Source Type: research

Approach to the new oral anticoagulants in family practice: Part 2: addressing frequently asked questions.
CONCLUSION: Management of "what if" scenarios for patients taking NOACs have been proposed, but additional study is needed to address these issues, especially periprocedural management and bleeding. PMID: 25392439 [PubMed - as supplied by publisher]
Source: Canadian Family Physician Medecin de Famille Canadien - November 1, 2014 Category: Primary Care Authors: Douketis J, Bell AD, Eikelboom J, Liew A Tags: Can Fam Physician Source Type: research

Antistreptokinase antibodies and outcome of fibrinolytic therapy with streptokinase for left-sided prosthetic valve thrombosis
Conclusion Anti-SK antibody titers are not associated with success of fibrinolytic therapy using SK in patients with left-sided PVT.
Source: American Heart Journal - November 17, 2014 Category: Cardiology Source Type: research

Have antibiotic changes upped heart infections?
Conclusion This is valuable and timely research, which has looked at trends before and after NICE's 2008 guidance on the prevention of infective endocarditis in people undergoing invasive procedures. This examined: changes in the prescription of antibiotics for the prevention of infective endocarditis changes in the number of cases of infective endocarditis diagnosed NICE's recommendation was based on an examination of the evidence of the effectiveness of antibiotics in preventing infective endocarditis, weighing the benefits and health outcomes (such as reduction in illness and deaths), risks and costs.   The ...
Source: NHS News Feed - November 19, 2014 Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

Pontine infarction responsible for wall-eyed bilateral internuclear ophthalmoplegia syndrome
A 68-year-old man with hypertension, cardiac arrhythmia, and a mechanical heart valve replacement treated with vitamin K antagonists was admitted for the acute onset of diplopia. Neuro-ophthalmologic examination showed a bilateral exotropia in primary gaze position (wall-eyed) with bilateral adduction deficit that did not improve by convergence (figure, video at Neurology.org/cp). In lateral gaze, a horizontal nystagmus of the abducting eyes appeared. Vertical saccades were normal (video). Pupils were symmetric and reactive to light. Brain MRI with diffusion-weighted images showed an acute pontine ischemic lesion (figure)....
Source: Nature Clinical Practice - December 8, 2014 Category: Neurology Authors: Mathis, T., Ducray, F., Tilikete, C., Vighetto, A., Biotti, D. Tags: Clinical neurology examination, All Neuro-ophthalmology, Ocular motility, Diplopia (double vision), All Cerebrovascular disease/Stroke Cases Source Type: research

Early and late outcomes of AVR with aortic annular enlargement in octogenarian
Conclusion AVR with aortic annular enlargement in octogenarians with small aortic annulus was safe and led to good operative and long-term outcomes.
Source: General Thoracic and Cardiovascular Surgery - May 14, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

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