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Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Prolonged enoxaparin therapy compared with standard-of-care antithrombotic therapy in opiate-treated patients undergoing primary percutaneous coronary intervention.
Authors: Sumaya W, Parker WAE, Judge HM, Hall IR, Orme RC, Adam Z, Richardson JD, Rothman AMK, Morgan KP, Gunn JP, Storey RF Abstract A novel enoxaparin regimen consisting of intra-arterial bolus (0.75 mg/kg) followed by intravenous infusion (0.75 mg/kg/6 hours) has been developed as a possible solution to the delayed absorption of oral P2Y12 inhibitors in opiate-treated ST-elevation myocardial infarction (STEMI) patients undergoing primary angioplasty. We aimed to study the feasibility of this regimen as an alternative to standard-of-care treatment (SOC) with unfractionated heparin ± glycoprotein IIb/IIIa antago...
Source: Platelets - June 18, 2020 Category: Hematology Tags: Platelets Source Type: research

Association of Long-Term Exposure to Transportation Noise and Traffic-Related Air Pollution with the Incidence of Diabetes: A Prospective Cohort Study
Conclusion: We found a positive association between residential transportation noise and diabetes, adding to the growing body of evidence that noise pollution exposure may be independently linked to metabolic health and should be considered when developing public health interventions. https://doi.org/10.1289/EHP1279 Received: 26 October 2016 Revised: 07 May 2017 Accepted: 09 May 2017 Published: 31 August 2017 Address correspondence to C. Clark, Ove Arup and Partners, Acoustics, 13 Fitzroy Street, London, W1T 4BQ, UK. Telephone: +44 207755 4702. Email: Charlotte.Clark@arup.com The authors declare they have no actual o...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Reply Effects of Habitual Coffee Consumption on Vascular Function
We thank Dr. Siasos and colleagues for pointing out that habitual coffee consumption has been associated with improved endothelial function in elderly inhabitants of Ikaria Island (1). The improvement in endothelial function may in part account for the associations of moderate coffee intake (about 2 to 4 cups daily) with lower risks for coronary heart disease and stroke (2). Indeed, even in the setting of endothelium damage, coffee has the ability to prevent arterial thrombus formation, a benefit that is independent of its caffeine content (3). Recent studies also indicate that moderate daily coffee intake may confer pro...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - February 10, 2014 Category: Cardiology Source Type: research

Reply: Effects of Habitual Coffee Consumption on Vascular Function
We thank Dr. Siasos and colleagues for pointing out that habitual coffee consumption has been associated with improved endothelial function in elderly inhabitants of Ikaria Island . The improvement in endothelial function may in part account for the associations of moderate coffee intake (about 2 to 4 cups daily) with lower risks for coronary heart disease and stroke . Indeed, even in the setting of endothelium damage, coffee has the ability to prevent arterial thrombus formation, a benefit that is independent of its caffeine content . Recent studies also indicate that moderate daily coffee intake may confer protection a...
Source: Journal of the American College of Cardiology - November 1, 2013 Category: Cardiology Authors: James J. DiNicolantonio, James H. O'Keefe, Carl J. Lavie Tags: Letters to the Editor Source Type: research