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Effects of Thrombin on the Neurovascular Unit in Cerebral Ischemia.
Abstract Cerebral ischemia is a cerebrovascular disease with high morbidity and mortality that poses a significant burden on society and the economy. About 60% of cerebral ischemia is caused by thrombus, and the formation of thrombus proceeds from insoluble fibrin, following its transformation from liquid fibrinogen. In thrombus-induced ischemia, increased permeability of the blood-brain barrier (BBB), followed by the extravasation of blood components into the brain results in an altered brain microenvironment. Changes in the brain microenvironment affect brain function and the neurovascular unit (NVU), the workin...
Source: Cellular and Molecular Neurobiology - January 3, 2021 Category: Cytology Authors: Cao H, Seto SW, Bhuyan DJ, Chan HH, Song W Tags: Cell Mol Neurobiol Source Type: research