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Repeated intravenous thrombolysis after recurrent stroke. A case series and review of the literature
Conclusions: IV re-thrombolysis may be safe and effective when recurrent stroke occurs after a period of complete neurologic regression lasting at least 24h or minor disability (mRS score ≤2) lasting at least 3months since the previous stroke.Highlights:
Source: Journal of the Neurological Sciences - July 25, 2014 Category: Neurology Authors: Manuel Cappellari, Giuseppe Moretto, Paolo Bovi Tags: Original Articles Source Type: research

Experience of pediatric stroke from a tertiary medical center in North India
Conclusion: AIS is more common than ICH in this study and 8.9% patients died. Infection is the most common cause of pediatric stroke in Northern India which is amenable to therapy and is preventable.
Source: Journal of the Neurological Sciences - December 26, 2012 Category: Neurology Authors: Jayantee Kalita, Gourav Goyal, Usha Kant Misra Tags: Original Articles Source Type: research

Reservations against new oral anticoagulants after stroke and cerebral bleeding
Abstract: Dabigatran, rivaroxaban, and apixaban are the new oral anticoagulants (NOAC) which have been investigated in patients with atrial fibrillation (AF) for primary and secondary prevention of stroke and thromboembolism. In these trials NOAC had a similar efficacy and safety profile compared to traditional vitamin-K-antagonists such as warfarin. We advise caution in the use of NOAC in patients with stroke or cerebral hemorrhage because of the following reasons:1) Patients with cerebral bleeding were excluded from the trials. 2) Stroke within 14days and severe stroke within 6months before screening were exclusion crite...
Source: Journal of the Neurological Sciences - April 29, 2013 Category: Neurology Authors: Claudia Stöllberger, Josef Finsterer Tags: Opinion Source Type: research

Gastrointestinal complications after ischemic stroke
Ischemic stroke is an important cause of morbidity and mortality, and currently the leading cause of adult disability in developed countries. Stroke is associated with various non-neurological medical complications, including infections and thrombosis. Gastrointestinal complications after stroke are also common, with over half of all stroke patients presenting with dysphagia, constipation, fecal incontinence or gastrointestinal bleeding. These complications are associated with increased hospital length of stay, the development of further complications and even increased mortality.
Source: Journal of the Neurological Sciences - September 4, 2014 Category: Neurology Authors: Carlos R. Camara-Lemarroy, Beatriz E. Ibarra-Yruegas, Fernando Gongora-Rivera Tags: Review article Source Type: research

Pathological features of intracardiac bacterial vegetation and intracranial arterial thrombus due to infective endocarditis in a stroke patient
We report herein on autopsy and pathological findings for IE-related stroke in a patient receiving hemodialysis.
Source: Journal of the Neurological Sciences - October 17, 2014 Category: Neurology Authors: Takashi Shimoyama, Naoki Saji, Junichi Uemura, Kensaku Shibazaki, Hirotake Nishimura, Kazumi Kimura Tags: Letter to the Editor Source Type: research

MRI based thrombolysis for FLAIR-negative stroke patients within 4.5 –6h after symptom onset
To investigate the feasibility of DWI-FLAIR mismatch in identifying patients who might benefit from thrombolytic therapy within 4.5 –6h, we analyzed the data of 105 ischemic stroke patients with known time of symptom onset who underwent MRI within 6h of stroke and thrombolysis between December 2006 and December 2013. They were divided into three groups: symptom onset within 4.5h (n=66); 4.5–6h and FLAIR images negative (n=9) ; and 4.5–6h and FLAIR images positive (n=30). Outcome of thrombolysis was assessed for each group by recanalization rate, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores.
Source: Journal of the Neurological Sciences - November 8, 2016 Category: Neurology Authors: Xiao-Er Wei, Jia Zhou, Wen-Bin Li, Yu-Wu Zhao, Ming-Hua Li, Yue-Hua Li Source Type: research

Carotid webs in large vessel occlusion stroke: Clinical, radiological and thrombus histopathological findings
Carotid webs are an under-recognized embolic source in patients with cryptogenic stroke. Limited resources currently exist to assist clinicians in stroke prevention for patients with symptomatic carotid webs (SCW). We aimed at analysing the clinical, radiological and procedural features of stroke patients with SCW undergoing endovascular thrombectomy (EVT), and to describe the histopathological composition of their occlusive thrombi.
Source: Journal of the Neurological Sciences - June 21, 2021 Category: Neurology Authors: Aurora Semerano, Zakaria Mamadou, Jean Philippe Desilles, Candice Sabben, Marco Bacigaluppi, Michel Piotin, Mickael Mazighi, Lucas Di Meglio, Michael Obadia Tags: Clinical short communication Source Type: research

Cerebral edema in acute stroke: Effect of thrombolytic treatment
Cerebral edema (CED) is a common complication of ischemic stroke in Intensive Care Unit. Although frequently observed in patients undergoing intravenous thrombolytic (IVT) treatment, the pathogenic role of recombinant tissue plasminogen activator (rtPA) in CED induction has not yet been definitively clarified. The aim of our study is to verify the relationship between CED and rtPA in patients affected by acute ischemic stroke, without reperfusion signs, evaluating the CED growth rate in the first week after stroke onset.
Source: Journal of the Neurological Sciences - February 22, 2022 Category: Neurology Authors: Giovanni Frisullo, Simone Bellavia, Irene Scala, Pierandrea Rizzo, Aldobrando Broccolini, Valerio Brunetti, Maria Pepe, Fabio Pilato, Roberta Morosetti, Giacomo Della Marca, Paolo Calabresi Source Type: research

CTP infarct core may predict poor outcome in stroke patients treated with IV t-PA
Conclusion: CTP parameters derived from commercially available software and published thresholds yield little predictive value for good clinical outcomes for AIS patients treated with IV t-PA but may be useful in predicting poor clinical outcome especially if the area of non-viable tissue is greater than 30cm2.Highlights:
Source: Journal of the Neurological Sciences - April 1, 2014 Category: Neurology Authors: Tzu-Ching Wu, Clark Sitton, Andrew Potter, Ritvij Bowry, Preeti Sahota, Chunyan Cai, Peng Hui, Zhongxue Chen, Nicole Gonzales, Andrew Barreto, George Lopez, James C. Grotta, Sean I. Savitz Tags: Original Articles Source Type: research

Spontaneous sternocleidomastoid muscle hematoma following thrombolysis for acute ischemic stroke
We report the case of an 83y.o. woman with right facio-brachio-crural hemiparesis, left deviation of the head and aphasia who developed, after thrombolytic therapy, a spontaneous sternocleidomastoid muscle hematoma that regressed few days later. To our knowledge, this is the first case reported in the literature of asymptomatic and spontaneous skeletal muscle hematoma following thrombolysis for the treatment of acute ischemic stroke. The occurrence of lateral cervical tuberculosis lymphadenitis ipsilateral to sternocleidomastoid muscle hematoma may suggest a causal relationship between local chronic inflammation of active ...
Source: Journal of the Neurological Sciences - April 28, 2014 Category: Neurology Authors: Nadia Mariagrazia Giannantoni, Giacomo Della Marca, Aldobrando Broccolini, Fabio Pilato, Paolo Profice, Roberta Morosetti, Pietro Caliandro, Giovanni Frisullo Tags: Letters to the Editor Source Type: research

Hyperglycemia predicts unfavorable outcomes in acute ischemic stroke patients treated with intravenous thrombolysis among a Chinese population: A prospective cohort study
In this study, we investigated whether an elevated admission serum glucose level in the 3-h time window of intravenous thrombolysis for acute ischemic stroke determined poor functional outcomes among Chinese population.
Source: Journal of the Neurological Sciences - March 16, 2018 Category: Neurology Authors: Sheng-Feng Lin, A-Ching Chao, Han-Hwa Hu, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Ming-Hui Sun, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Chi-Huey Bai, Taiwan Thrombolytic Therapy for Acut Source Type: research

Low-dose versus standard-dose intravenous alteplase for octogenerian acute ischemic stroke patients: A multicenter prospective cohort study
The optimal dose of alteplase for acute ischemic stroke among geriatric patients is unclear. We aimed to assess the efficacy and safety of a low-dose (0.6  mg/kg) and standard-dose (0.9 mg/kg) alteplase for varying severity of Asian geriatric stroke patients.
Source: Journal of the Neurological Sciences - January 29, 2019 Category: Neurology Authors: A-Ching Chao, Ke Han, Sheng-Feng Lin, Ruey-Tay Lin, Chih-Hung Chen, Lung Chan, Huey-Juan Lin, Yu Sun, Yung-Yang Lin, Po-Lin Chen, Shinn-Kuang Lin, Cheng-Yu Wei, Yu-Te Lin, Jiunn-Tay Lee, Han-Hwa Hu, Chyi-Huey Bai, On behalf of the Taiwan Thrombolytic Ther Source Type: research

Atrial fibrillation, not atrial cardiopathy, is associated with stroke: A single center retrospective study
Atrial fibrillation (AF) increases the risk of thromboembolism. Atrial cardiopathy, defined as structural left atrial enlargement (LAE), has been proposed to be a unifying risk factor for stroke, with or without atrial fibrillation (AF). We sought to understand the relative importance of LAE and AF as risk factors for stroke.
Source: Journal of the Neurological Sciences - May 14, 2019 Category: Neurology Authors: Muhammad Affan, Abhimanyu Mahajan, Sumul Modi, Lonni Schultz, Angelos Katramados, Stephan A. Mayer, Daniel Miller Source Type: research

Paradoxical embolism through a patent foramen ovale from central venous catheter thrombosis: A potential cause of stroke
Paradoxical embolism refers to a potential condition in which an embolus arising from a venous source crosses into the systemic circulation through a right-to-left cardiac shunt causing an arterial embolism.A 39-year-old woman carrier of a central venous catheter (CVC) without evident risk factors for stroke, developed an acute right homonymous hemianopia during hemodialysis. On neuroimaging, an infarct in the territory of the left posterior cerebral artery was demonstrated. Transesophageal echocardiography revealed a patent foramen ovale (PFO) and a large fluctuating thrombus in the right atrium on the tip of the CVC, thu...
Source: Journal of the Neurological Sciences - April 3, 2020 Category: Neurology Authors: Di Stefano Vincenzo, Di Fulvio Maria, Di Liberato Lorenzo, Onofrj Marco, De Angelis Maria Vittoria Tags: Clinical Short Communication Source Type: research

Outcomes after acute ischemic stroke in patients with thrombocytopenia or thrombocytosis
Thrombocytopenia may be associated with a greater risk of cerebral hemorrhage and thrombocytosis may be associated with a greater risk of cerebral thrombosis. There is a paucity of studies focused on the potential association between blood platelet count (BPC) and outcomes after acute ischemic stroke (AIS). We hypothesized that abnormal BPC is associated with poorer outcomes after AIS.
Source: Journal of the Neurological Sciences - January 23, 2016 Category: Neurology Authors: Julio C. Furlan, Jiming Fang, Frank L. Silver Source Type: research

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