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Inherited thrombophilia associated with ischemic pediatric stroke in parents-child pairs
We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not-investigated polymorphisms, in children with ischemic pediatric stroke (IPS) and their parents.The study included 33 children: 23 with perinatal (PAIS), 8 with childhood arterial ischemic stroke (CAIS) and 2 with sinovenous thrombosis (SVT) and their parents (33 mother-child, 12 father-child and 12 mother-father-child pairs). Genotyping of FV-Leiden, FV-H1299R, FII-G20210A, β-fibrinogen-455G>A, FXIII-A-Val34Leu, PAI-1(4G/5G), HPA-1, MTHFR-C677T, MTHFR-A1298C, ACE(I/D) and APOE( ε2-4) was performed using CVD St...
Source: Pediatric Neurology - June 27, 2023 Category: Neurology Authors: Jasna Lenicek Krleza, Desiree Coen Herak, Ivana Đakovic, Katarina Vulin, Goran Roic, Ana Tripalo Batoš, Andrea Čeri, Renata Zadro, Vlasta Đuranovic Tags: Research Paper Source Type: research

Before blaming SARS-CoV-2 for cerebrovascular disease in children, all differentials need to be ruled out
We read with interest the article by Spanelova et al. about four pediatric patients with cerebrovascular complications after a putative SARS-CoV-2 infection [1]. Patient-1 was diagnosed with subdural hematoma (SDH) and meningitis, patient-2 with cerebral vasculitis, patient-3 with lacunar stroke, and patient-4 with venous sinus thrombosis (VST) with haemorrhage [1]. It was concluded that SARS-CoV-2 infections in children can be complicated by cerebro-vascular disease [1]. The study is promising but raises concerns that should be discussed.
Source: Pediatric Neurology - February 14, 2023 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research

Successful Manual Aspiration Thrombectomy in  a Pediatric Patient
Timely recognition of stroke at major pediatric medical centers is improving, and although treatment guidelines for pediatric stroke exist, no extensive study establishing the efficacy of surgical or thrombolytic treatment has been completed. Extrapolation of adult guidelines to pediatric patients remains the mainstay of treatment in the absence of adequate information regarding safety and efficacy in children. Recent trials have demonstrated revascularization and clinical improvement after endovascular retrieval therapy in adults with acute large vessel occlusive stroke.
Source: Pediatric Neurology - March 21, 2016 Category: Neurology Authors: Gregory M. Weiner, Rafey A. Feroze, BSE, Nitin Agarwal, David M. Pancykowski, William J. Ares, Ali Kooshkabadi, Dana D. Cummings, Vincent Carson, Amin Aghaebrahim, Brian T. Jankowitz Tags: Topical Review Source Type: research

Successful Manual Aspiration Thrombectomy in a Pediatric Patient
Timely recognition of stroke at major pediatric medical centers is improving, and although treatment guidelines for pediatric stroke exist, no extensive study establishing the efficacy of surgical or thrombolytic treatment has been completed. Extrapolation of adult guidelines to pediatric patients remains the mainstay of treatment in the absence of adequate information regarding safety and efficacy in children. Recent trials have demonstrated revascularization and clinical improvement after endovascular retrieval therapy in adults with acute large vessel occlusive stroke.
Source: Pediatric Neurology - March 21, 2016 Category: Neurology Authors: Gregory M. Weiner, Rafey A. Feroze, BSE, Nitin Agarwal, David M. Pancykowski, William J. Ares, Ali Kooshkabadi, Dana D. Cummings, Vincent Carson, Amin Aghaebrahim, Brian T. Jankowitz Tags: Topical Review Source Type: research

Successful Manual Aspiration Thrombectomy in  a Pediatric Patient
Timely recognition of stroke at major pediatric medical centers is improving, and although treatment guidelines for pediatric stroke exist, no extensive study establishing the efficacy of surgical or thrombolytic treatment has been completed. Extrapolation of adult guidelines to pediatric patients remains the mainstay of treatment in the absence of adequate information regarding safety and efficacy in children. Recent trials have demonstrated revascularization and clinical improvement after endovascular retrieval therapy in adults with acute large vessel occlusive stroke.
Source: Pediatric Neurology - March 21, 2016 Category: Neurology Authors: Gregory M. Weiner, Rafey A. Feroze, BSE, Nitin Agarwal, David M. Pancykowski, William J. Ares, Ali Kooshkabadi, Dana D. Cummings, Vincent Carson, Amin Aghaebrahim, Brian T. Jankowitz Tags: Topical Review Source Type: research

A Case of Successful Manual Aspiration Thrombectomy in a Pediatric Patient
Timely recognition of pediatric stroke at major medical centers is improving and while treatment guidelines for pediatric stroke exist, no extensive study establishing the efficacy of surgical or thrombolytic treatment has been completed. Extrapolation of adult guidelines to pediatric patients remains the mainstay of treatment without adequate information available regarding safety and efficacy in children. Recent trials have demonstrated revascularization and clinical improvement following endovascular retrieval therapy in adults with acute large vessel occlusive stroke.
Source: Pediatric Neurology - March 21, 2016 Category: Neurology Authors: Gregory M. Weiner, Rafey A. Feroze, Nitin Agarwal, David M. Pancykowski, William J. Ares, Ali Kooshkabadi, Dana D. Cummings, Vincent Carson, Amin Aghaebrahim, Brian T. Jankowitz Tags: Topical Review Source Type: research

Genetic Risk Factors for Perinatal Arterial Ischemic Stroke
Abstract: The cause of perinatal arterial ischemic stroke is unknown in most cases. We explored whether genetic polymorphisms modify the risk of perinatal arterial ischemic stroke. In a population-based case-control study of 1997-2002 births at Kaiser Permanente Northern California, we identified 13 white infants with perinatal arterial ischemic stroke. Control subjects included 86 randomly selected white infants. We genotyped polymorphisms in nine genes involved in inflammation, thrombosis, or lipid metabolism previously linked with stroke, and compared genotype frequencies in case and control individuals. We tested sever...
Source: Pediatric Neurology - January 1, 2013 Category: Neurology Authors: Amy A. Gelfand, Lisa A. Croen, Anthony R. Torres, Yvonne W. Wu Tags: Original Articles Source Type: research