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Source: Pediatric Neurology
Condition: Thrombosis

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Total 17 results found since Jan 2013.

Inherited thrombophilia associated with ischemic pediatric stroke in parents-child pairs
We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not-investigated polymorphisms, in children with ischemic pediatric stroke (IPS) and their parents.The study included 33 children: 23 with perinatal (PAIS), 8 with childhood arterial ischemic stroke (CAIS) and 2 with sinovenous thrombosis (SVT) and their parents (33 mother-child, 12 father-child and 12 mother-father-child pairs). Genotyping of FV-Leiden, FV-H1299R, FII-G20210A, β-fibrinogen-455G>A, FXIII-A-Val34Leu, PAI-1(4G/5G), HPA-1, MTHFR-C677T, MTHFR-A1298C, ACE(I/D) and APOE( ε2-4) was performed using CVD St...
Source: Pediatric Neurology - June 27, 2023 Category: Neurology Authors: Jasna Lenicek Krleza, Desiree Coen Herak, Ivana Đakovic, Katarina Vulin, Goran Roic, Ana Tripalo Batoš, Andrea Čeri, Renata Zadro, Vlasta Đuranovic Tags: Research Paper Source Type: research

Before blaming SARS-CoV-2 for cerebrovascular disease in children, all differentials need to be ruled out
We read with interest the article by Spanelova et al. about four pediatric patients with cerebrovascular complications after a putative SARS-CoV-2 infection [1]. Patient-1 was diagnosed with subdural hematoma (SDH) and meningitis, patient-2 with cerebral vasculitis, patient-3 with lacunar stroke, and patient-4 with venous sinus thrombosis (VST) with haemorrhage [1]. It was concluded that SARS-CoV-2 infections in children can be complicated by cerebro-vascular disease [1]. The study is promising but raises concerns that should be discussed.
Source: Pediatric Neurology - February 14, 2023 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research

Cerebral Vascular Complications of Pediatric Blunt Trauma
Ischemic and hemorrhagic stroke can occur in the setting of pediatric trauma, particularly those with head or neck injuries. The risk of stroke appears highest within the first two weeks after trauma. Stroke diagnosis may be challenging due to lack of awareness or concurrent injuries limiting detailed neurologic assessment. Other injuries may also complicate stroke management, with competing priorities for blood pressure, ventilator management, or antithrombotic timing. Here we review epidemiology, clinical presentation and diagnostic approach to blunt arterial injuries including dissection, cerebral sinovenous thrombosis,...
Source: Pediatric Neurology - January 9, 2020 Category: Neurology Authors: Maria M. Galardi, Jennifer M. Strahle, Alex Skidmore, Akash P. Kansagra, Kristin P. Guilliams Tags: Review Article Source Type: research

Cerebrovascular Complications of Pediatric Blunt Trauma
Ischemic and hemorrhagic stroke can occur in the setting of pediatric trauma, particularly those with head or neck injuries. The risk of stroke appears highest within the first two weeks after trauma. Stroke diagnosis may be challenging due to lack of awareness or concurrent injuries limiting detailed neurological assessment. Other injuries may also complicate stroke management, with competing priorities for blood pressure, ventilator management, or antithrombotic timing. Here we review epidemiology, clinical presentation, and diagnostic approach to blunt arterial injuries including dissection, cerebral sinovenous thrombos...
Source: Pediatric Neurology - January 9, 2020 Category: Neurology Authors: Maria M. Galardi, Jennifer M. Strahle, Alex Skidmore, Akash P. Kansagra, Kristin P. Guilliams Tags: Review Article Source Type: research

Hemorrhagic Transformation of Arterial Ischemic and Venous Stroke in Children
Hemorrhagic transformation can complicate both arterial ischemic stroke (AIS) and cerebral sinus venous thrombosis (CSVT). Risk factors for hemorrhagic transformation after adult AIS include larger infarct volume, cardioembolic stroke, and anticoagulation in the acute period. Large hemorrhagic transformation in adults is associated with poor outcome. Therefore, hemorrhagic transformation is used as a safety endpoint of most AIS acute treatment and secondary prevention trials. Up to 30% of children with AIS have hemorrhagic transformation, most of which is petechial.
Source: Pediatric Neurology - February 7, 2019 Category: Neurology Authors: Melissa L. Hutchinson, Lauren A. Beslow Tags: Topical Review Source Type: research

Cerebral Developmental Venous Anomaly- Preventing stroke in acute sinus thrombosis?
A 14 year old boy with no significant medical history presented with progressively worsening headache for 3 weeks, followed by acute encephalopathy and signs of raised intracranial pressure (ICP) including hypertension and bradycardia. CT head showed a large right transverse/sigmoid sinus thrombus and obstructive hydrocephalus. He underwent an urgent external ventricular drain placement.MRI demonstrated a large right transverse/sigmoid sinus thrombus, large bilateral cerebellar developmental venous anomalies (DVAs) and obstructive hydrocephalus.
Source: Pediatric Neurology - March 31, 2017 Category: Neurology Authors: Ajay Goenka, William Gomes, Jules Beal Tags: Visual Diagnosis Source Type: research

Cerebral Developmental Venous Anomaly —Does it Prevent Stroke in Acute Sinus Thrombosis?
This 14-year-old boy developed progressively severe headache for three weeks followed by acute encephalopathy and signs of increased intracranial pressure with systemic hypertension and bradycardia. Computed tomography head showed a large right transverse/sigmoid sinus thrombus and obstructive hydrocephalus (Figure). He underwent an urgent external ventricular drain placement. Magnetic resonance imaging demonstrated a large right transverse/sigmoid sinus thrombus, large bilateral cerebellar developmental venous anomalies (DVAs), and obstructive hydrocephalus.
Source: Pediatric Neurology - March 31, 2017 Category: Neurology Authors: Ajay Goenka, William Gomes, Jules C. Beal Tags: Visual Diagnosis Source Type: research

Successful Manual Aspiration Thrombectomy in a Pediatric Patient
Timely recognition of stroke at major pediatric medical centers is improving, and although treatment guidelines for pediatric stroke exist, no extensive study establishing the efficacy of surgical or thrombolytic treatment has been completed. Extrapolation of adult guidelines to pediatric patients remains the mainstay of treatment in the absence of adequate information regarding safety and efficacy in children. Recent trials have demonstrated revascularization and clinical improvement after endovascular retrieval therapy in adults with acute large vessel occlusive stroke.
Source: Pediatric Neurology - March 21, 2016 Category: Neurology Authors: Gregory M. Weiner, Rafey A. Feroze, BSE, Nitin Agarwal, David M. Pancykowski, William J. Ares, Ali Kooshkabadi, Dana D. Cummings, Vincent Carson, Amin Aghaebrahim, Brian T. Jankowitz Tags: Topical Review Source Type: research

A Case of Successful Manual Aspiration Thrombectomy in a Pediatric Patient
Timely recognition of pediatric stroke at major medical centers is improving and while treatment guidelines for pediatric stroke exist, no extensive study establishing the efficacy of surgical or thrombolytic treatment has been completed. Extrapolation of adult guidelines to pediatric patients remains the mainstay of treatment without adequate information available regarding safety and efficacy in children. Recent trials have demonstrated revascularization and clinical improvement following endovascular retrieval therapy in adults with acute large vessel occlusive stroke.
Source: Pediatric Neurology - March 21, 2016 Category: Neurology Authors: Gregory M. Weiner, Rafey A. Feroze, Nitin Agarwal, David M. Pancykowski, William J. Ares, Ali Kooshkabadi, Dana D. Cummings, Vincent Carson, Amin Aghaebrahim, Brian T. Jankowitz Tags: Topical Review Source Type: research

Prognostication Value of Descending Corticospinal Tract DWI signal in Neonatal Cerebral Sinovenous Thrombosis: A Case Report
Descending corticospinal tract diffusion-weighted MRI signal (DCST DWI) is predictive of poor motor outcome in neonatal and childhood arterial ischemic stroke (AIS). However, DCST DWI has not been documented in the setting of cerebral sinovenous thrombosis (CSVT) and its role is not understood.
Source: Pediatric Neurology - March 2, 2016 Category: Neurology Authors: M.L. Kaseka, M. Moharir, G. DeVeber, D. MacGregor, R. Askalan, N. Dlamini Tags: Clinical Observations Source Type: research

Guidelines for Urgent Management of Stroke in Children
Stroke in children carries lasting morbidity. Once recognized, it is important to evaluate and treat children with acute stroke efficiently and accurately. All children should receive neuroprotective measures. It is reasonable to consider treatment with advanced thrombolytic and endovascular agents. Delivery of such care requires purposeful institutional planning and organization in pediatric acute care centers. Primary stroke centers established for adults provide an example of the multidisciplinary approach that can be applied to the evaluation and treatment of children who present with acute stroke.
Source: Pediatric Neurology - January 21, 2016 Category: Neurology Authors: Michael J. Rivkin, Timothy J. Bernard, Michael M. Dowling, Catherine Amlie-Lefond Tags: Review Article Source Type: research

Early Wallerian degeneration in a neonate with MCA stroke
A 23-day-old female with history of transposition of great arteries, ventricular septal defect, pulmonary stenosis and placement of right modified Blalock-Taussig shunt complicated by thrombosis at age 9 days of life presented with episodes of upper extremity extension and gasping respirations concerning for seizure. Brain MRI demonstrated an extensive, acute right middle carotid artery (MCA) territory stroke with occlusion of the right proximal MCA. There was also a small left frontal stroke. Diffusion restriction abnormalities with simultaneous presence of hyperintensity on T2 sequences in the cotricospinal tract consist...
Source: Pediatric Neurology - October 31, 2014 Category: Neurology Authors: Olga D. Taraschenko, Charles Nichter, John Pugh Tags: Visual Diagnosis Source Type: research

Early Wallerian Degeneration in a Neonate With Middle Carotid Artery Stroke
A 23-day-old girl with a history of transposition of the great arteries, ventricular septal defect, pulmonary stenosis, and placement of right modified Blalock-Taussig shunt complicated by thrombosis at age 9 days of life presented with episodes of upper extremity extension and gasping respirations concerning for seizure. Brain magnetic resonance imaging demonstrated an extensive, acute right middle carotid artery territory stroke with occlusion of the right proximal middle carotid artery. There was also a small left frontal stroke.
Source: Pediatric Neurology - October 31, 2014 Category: Neurology Authors: Olga D. Taraschenko, Charles Nichter, John A. Pugh Tags: Visual Diagnosis Source Type: research

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