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Similar Outcomes for Contact Aspiration and Stent Retriever Use According to the Admission Clot Burden Score in ASTER Clinical Sciences
Conclusions—First-line mechanical thrombectomy with contact aspiration compared with stent retriever did not result in an increased successful reperfusion rate in acute ischemic stroke patients with large vessel occlusion of the anterior circulation according to the admission CBS. The latter, however, seems to be a reliable prognostic indicator of angiographic and clinical outcome.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Francois Zhu, Bertrand Lapergue, Maeva Kyheng, Raphael Blanc, Julien Labreuche, Malek Ben Machaa, Alain Duhamel, Gautier Marnat, Suzana Saleme, Vincent Costalat, Serge Bracard, Sebastien Richard, Hubert Desal, Mikael Mazighi, Arturo Consoli, Michel Piotin Tags: Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Erythrocyte Fraction Within Retrieved Thrombi Contributes to Thrombolytic Response in Acute Ischemic Stroke Clinical Sciences
Conclusions—In EVT-attempted patients with acute ischemic stroke, IVT responsiveness would be closely associated with RBC fraction.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Mun Hee Choi, Geun Hwa Park, Jin Soo Lee, Sung Eun Lee, Seong-Joon Lee, Jang-Hee Kim, Ji Man Hong Tags: Ischemic Stroke Original Contributions Source Type: research

Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke Clinical Sciences
Conclusions—Patients with lower thrombus burden and higher thrombus perviousness scores had higher collateral score. The positive effect of thrombus perviousness on clinical outcome was only present in patients with moderate and high collateral scores.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR1804 and URL: http://www.controlled-trials.com Unique identifier: ISRCTN10888758.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Heitor C. Alves, Kilian M. Treurniet, Bruna G. Dutra, Ivo G. H. Jansen, Anna M.M. Boers, Emilie M.M. Santos, Olvert A. Berkhemer, Diederik W.J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, Hester F. Lingsma, Yvo B.W.E.M. Roos, Al Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Ischemic Stroke Clinical Sciences
Conclusions—Histological thrombus features vary significantly according to the underlying cause and may help to differentiate between cardioembolic and noncardioembolic stroke. In addition, our study supports the hypothesis that most cryptogenic strokes have a cardioembolic cause.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Peter B. Sporns, Uta Hanning, Wolfram Schwindt, Aglae Velasco, Jens Minnerup, Tarek Zoubi, Walter Heindel, Astrid Jeibmann, Thomas Ulrich Niederstadt Tags: Angiography, Revascularization, Cerebrovascular Disease/Stroke, Ischemic Stroke, Embolism Original Contributions Source Type: research

Impact of Thrombus Length on Outcomes After Intra-Arterial Aspiration Thrombectomy in the THERAPY Trial Clinical Sciences
Conclusions—Ischemic stroke patients with longer symptomatic thrombi have worse 90-day clinical outcomes but may have a greater relative benefit of aspiration thrombectomy over IV r-tPA alone.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01429350.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Albert J. Yoo, Pooȷa Khatri, J Mocco, Osama O. Zaidat, Rishi Gupta, Donald Frei, Demetrius Lopes, Harish Shownkeen, Olvert A. Berkhemer, Denise Meyer, Susana S. Hak, Sophia S. Kuo, Hope Buell, Arani Bose, Siu Po Sit, Rudiger von Kummer Tags: Computerized Tomography (CT), Imaging, Revascularization, Ischemic Stroke Original Contributions Source Type: research

Nongated Cardiac Computed Tomographic Angiograms for Detection of Embolic Sources in Acute Ischemic Stroke Clinical Sciences
Conclusions—Including the heart and ascending aorta in a routine non–ECG-gated computed tomographic angiogram enhances an existing imaging modality, with no increased incidence of contrast-induced nephropathy and minimal increase in radiation dose. This may help in the detection of high-risk cardiac and aortic sources of embolism in acute stroke patients.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Leonard L.L. Yeo, Staffan Holmin, Tommy Andersson, Erik Lundstrom, Anil Gopinathan, Er Luen Lim, Benȷamin S.H. Leong, Win Sen Kuan, Eric Ting, Benȷamin Y.Q. Tan, Sterling Ellis Eide, Edgar L.K. Tay Tags: Computerized Tomography (CT), Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Venous Thrombotic Recurrence After Cerebral Venous Thrombosis Clinical Sciences
Conclusions—In our cohort of CVT patients followed on average for>6 years, subjects with a previous venous thrombotic event, cancer/malignant hemopathies, and unknown CVT causes were found to be at higher risk of recurrence.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Paola Palazzo, Pierre Agius, Pierre Ingrand, Jonathan Ciron, Matthias Lamy, Aline Berthomet, Paul Cantagrel, Jean-Philippe Neau Tags: Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Is Unexplained Early Neurological Deterioration After Intravenous Thrombolysis Associated With Thrombus Extension? Clinical Sciences
Conclusions—In this study, unexplained END occurring after thrombolysis was independently associated with susceptibility vessel sign extension, suggesting in situ thrombus extension or re-embolization. These findings strengthen the need to further investigate early post-thrombolysis administration of antithrombotics to reduce the risk of this ominous clinical event.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Pierre Seners, Robert Hurford, Marie Tisserand, Guillaume Turc, Laurence Legrand, Olivier Naggara, Jean-Louis Mas, Catherine Oppenheim, Jean-Claude Baron Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research

Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Thrombus perviousness, as measured on computed tomography in the acute stage of ischemic stroke, is strongly associated with recanalization after intravenous r-tPA treatment and with favorable functional outcome.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Santos, E. M. M., Dankbaar, J. W., Treurniet, K. M., Horsch, A. D., Roos, Y. B., Kappelle, L. J., Niessen, W. J., Majoie, C. B., Velthuis, B., Marquering, H. A., on behalf of the DUST Investigators, Duijm, Keizer, van der Lugt, Dippel, Droogh - de Greeve, Tags: Computerized Tomography (CT), Prognosis, Revascularization, Treatment, Ischemic Stroke Clinical Sciences Source Type: research

Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke Clinical Sciences
Conclusions— This study shows that simultaneous measurement of thrombus attenuation in noncontrast computed tomography and computed tomographic angiography allows for quantification of thrombus perviousness. Thrombus perviousness is strongly associated with improved functional outcome, smaller final infarct volume, and higher recanalization rate.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Santos, E. M. M., Marquering, H. A., den Blanken, M. D., Berkhemer, O. A., Boers, A. M. M., Yoo, A. J., Beenen, L. F., Treurniet, K. M., Wismans, C., van Noort, K., Lingsma, H. F., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., Tags: Angiography, Computerized Tomography (CT), Quality and Outcomes, Ischemic Stroke, Thrombosis Clinical Sciences Source Type: research

Thrombus Length Estimation on Delayed Gadolinium-Enhanced T1 Clinical Sciences
Conclusions— The dGE-T1, obtained by simply adjusting scanning order in multimodal magnetic resonance imaging protocol, is a useful tool for thrombus length estimation and middle cerebral artery recanalization prediction after IVT.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Yan, S., Chen, Q., Xu, M., Sun, J., Liebeskind, D. S., Lou, M. Tags: Angiography, Ischemic Stroke Clinical Sciences Source Type: research

Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion Basic Sciences
Conclusions— A novel intra-arterial, nanoparticle-based thrombolytic therapy combined with TEB achieves high rates of complete recanalization. Moreover, this approach reduces vascular trauma as compared with stent-retriever thrombectomy.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Marosfoi, M. G., Korin, N., Gounis, M. J., Uzun, O., Vedantham, S., Langan, E. T., Papa, A.-L., Brooks, O. W., Johnson, C., Puri, A. S., Bhatta, D., Kanapathipillai, M., Bronstein, B. R., Chueh, J.-Y., Ingber, D. E., Wakhloo, A. K. Tags: Animal Models of Human Disease, Angiography, Treatment, Cerebrovascular Disease/Stroke Basic Sciences Source Type: research

Intracranial Dural Arteriovenous Fistulae: Clinical Presentation and Management Strategies Topical Reviews
Source: Stroke - June 22, 2015 Category: Neurology Authors: Miller, T. R., Gandhi, D. Tags: CT and MRI, Acute Cerebral Hemorrhage, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Cerebral Venous Thrombosis, Angiography, Intracerebral Hemorrhage, Aneurysm, AVM, hematoma Topical Reviews Source Type: research

Effect Size Estimates for the ESCAPE Trial: Proportional Odds Regression Versus Other Statistical Methods Clinical Sciences
Conclusions— The mRS distribution for both treatment and control groups influences the power of the investigated statistical models to assess treatment efficacy. A careful evaluation of the expected outcome distribution across the mRS scale is required to determine the best choice of primary analysis.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Sajobi, T. T., Zhang, Y., Menon, B. K., Goyal, M., Demchuk, A. M., Broderick, J. P., Hill, M. D. Tags: Thrombolysis, Other Stroke Treatment - Surgical Clinical Sciences Source Type: research

Occult Anterograde Flow Is an Under-Recognized but Crucial Predictor of Early Recanalization With Intravenous Tissue-Type Plasminogen Activator Clinical Sciences
Conclusions— Occult anterograde flow through thrombus can be assessed by perfusion computed tomography T0 maps and predicts early recanalization with intravenous tissue-type plasminogen activator robustly.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Ahn, S. H., d'Esterre, C. D., Qazi, E. M., Najm, M., Rubiera, M., Fainardi, E., Hill, M. D., Goyal, M., Demchuk, A. M., Lee, T. Y., Menon, B. K. Tags: Fibrinolysis, Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

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