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Multiple sclerosis clinical course and cardiovascular disease risk – Swedish cohort study
ConclusionsThere is a significantly increased relative risk for CVD in MS, particularly for venous thromboembolic disorders in progressive MS, suggesting immobility as a possible factor. An increased frequency of ischaemic stroke in MS is most probably due to surveillance bias resulting from diagnostic investigations for MS. There is no increased relative risk for ischaemic heart disease in MS and atrial fibrillation appears to be less common than amongst the general population.
Source: European Journal of Neurology - July 16, 2014 Category: Neurology Authors: H. Roshanisefat, S. Bahmanyar, J. Hillert, T. Olsson, S. Montgomery Tags: Original Article Source Type: research

Intracranial artery dissection
The aim of this narrative review is to evaluate the pathogenesis, clinical features, diagnosis, treatment and prognosis of intracranial artery dissection (IAD). IAD is a rare and often unrecognized cause of stroke or subarachnoid haemorrhage (SAH), especially in young adults. Two types of IAD can be identified: a subintimal or subadventitial dissection. It is suggested that a subintimal dissection results in luminal stenosis, thromboembolism and subsequently cerebral ischaemia, whilst a subadventitial IAD could result in the formation of a pseudo‐aneurysm and compression on brainstem or cranial nerves. Rupture of such a ...
Source: European Journal of Neurology - February 23, 2014 Category: Neurology Authors: T. Sikkema, M. Uyttenboogaart, O. Eshghi, J. De Keyser, R. Brouns, J. M. C. Dijk, G. J. Luijckx Tags: Review Article Source Type: research

Endothelial markers are associated with thrombolysis resistance in acute stroke patients
ConclusionsRecanalization after thrombolytic therapy is associated with low sTM and sEPCR levels but not with vWF levels. If corroborated in further larger studies, these findings could be helpful in the identification of patients resistant to rt‐PA thrombolysis who could benefit from a modified recanalization therapy.
Source: European Journal of Neurology - February 4, 2014 Category: Neurology Authors: D. Faille, J. Labreuche, E. Meseguer, M.‐G. Huisse, N. Ajzenberg, M. Mazighi Tags: Original Article Source Type: research

Diabetes and thrombolysis for acute stroke: a clear benefit for diabetics
ConclusionsData from this nationwide survey show that diabetic stroke patients receive a substantial benefit from thrombolysis, and therefore diabetic strokes should not be excluded from thrombolytic treatment.
Source: European Journal of Neurology - September 21, 2013 Category: Neurology Authors: M. Reiter, Y. Teuschl, K. Matz, L. Seyfang, M. Brainin, Tags: Original Article Source Type: research

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