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EE99 Cost-Effectiveness of Percutaneous Closure of a Patent Foramen Ovale (PFO) Versus Antiplatelet Therapy After Stroke: A Trial and Model Based Economic Evaluation of the French Close Randomised Controlled Trial
The French RCT CLOSE demonstrated that patients having experienced cryptogenic stroke and having a patent foramen ovale (PFO) with echocardiographic features representing risk of stroke benefited from PFO closure compared to antiplatelet therapy. This analysis determines the cost-effectiveness from the perspective of the French healthcare system of percutaneous PFO closure in combination with antiplatelet therapy versus antiplatelet therapy alone using economic data collected during the CLOSE trial.
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: M Darlington, Y Gaston, A Charles-Nelson, G Chatellier, JL Mas, I Durand-Zaleski Source Type: research

The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female
We present a case of a healthy, 38-year-old female military dependent who presented with an ischemic right posterior central gyrus stroke in the setting of a patent foramen ovale and supplement diindolylmethane use. This case serves as a reminder of the hazards associated with supplement use and the importance of a thorough investigation of etiology in medical cases of ischemic stroke in the young.PMID:36448494 | DOI:10.1093/milmed/usac367
Source: Military Medicine - November 30, 2022 Category: International Medicine & Public Health Authors: Sierra T Pence Ketan Mehta Jennifer Crum-Bailey Source Type: research

Stroke in Young Military Men With Heterozygous for MTHFR Gene Mutation or Factor V Leiden Gene Mutation Associated With Patent Foramen Ovale: Report of Two Cases and Therapeutic Strategy
We report two cases of Brazilian patients (a 22-year-old male and a 48-year-old male) with ischemic stroke, whose arterial vascular study and echocardiographic investigation did not reveal any steno-occlusive arterial disease or typical cardioembolic finding, such as atrial fibrillation or myocardial dysfunction. A transcranial Doppler ultrasound and a transesophageal echocardiogram showed a patent foramen ovale (PFO), and the laboratory screening for coagulation abnormalities showed heterozygosity for MTHFR C677T and A1298C in one of the patients and heterozygosity for factor V Leiden gene mutations in the other patient. ...
Source: Military Medicine - May 16, 2021 Category: International Medicine & Public Health Authors: Rodrigo Tavares Brisson Josev ânia Fulgêncio de Lima Arruda Liene Duarte Silva Dilermando Leal J únio de Jesus Viviane Flumignan Zetola Marcia Aparecida Camacho Kauffmann Nogueira Source Type: research

AAN updates recommendation on closure of common heart defect after stroke
(American Academy of Neurology) New guidance from the American Academy of Neurology (AAN) concludes that closure of a common heart defect called a patent foramen ovale (PFO) may be recommended for some people who have had a stroke. The updated practice advisory is published in the April 29, 2020, online issue of Neurology ® , the medical journal of the American Academy of Neurology.
Source: EurekAlert! - Medicine and Health - April 29, 2020 Category: International Medicine & Public Health Source Type: news

Final results from the RESPECT study reported at TCT 2016
(Cardiovascular Research Foundation) Final results from the RESPECT trial found that percutaneously closing a patent foramen ovale (PFO) using the Amplatzer PFO Occluder was superior to medical management in the prevention of recurrent ischemic stroke in patients who previously had a cryptogenic stroke.
Source: EurekAlert! - Medicine and Health - November 1, 2016 Category: Global & Universal Source Type: news

Bayesian Network Meta-Analysis on Prevention of Stroke For Patent Foramen Ovale Closure
Stroke is associated with high rates of morbidity and is the globally second leading cause of death. Up to 40% of ischaemic strokes are cryptogenic. A network meta-analysis to compare the effectiveness of patent foramen ovale closure in patients with cryptogenic stroke or embolism.
Source: Value in Health - April 30, 2016 Category: Global & Universal Authors: S. Aggarwal, S. Kumar, H. Topaloglu Source Type: research

Network Meta-Analysis On Prevention Of Stroke For Patent Foramen Ovale Closure
Strokes are associated with high rates of morbidity and are the global second leading cause of death. Up to 40% of ischaemic strokes are cryptogenic. A network meta-analysis to compare the effectiveness of patent foramen ovale closure in patients with cryptogenic stroke or embolism.
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: S Aggarwal, S Kumar, H Topaloglu Source Type: research